Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft

Transplant International

Volumn 13, Issue SUPPL. 1, 2000, Pages

  Hayashi, S ^a   Guang Lin, M ^a   Yokoyama, I ^a   Namii, Y ^a   Hamada, H ^b   Nakao, A ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b The Japan Foundation   (Japan)

Author keywords

CTLA4Ig; Gene therapy; Transplantation

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; BETA GALACTOSIDASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN;

ADENOVIRUS; ALLOTRANSPLANTATION; ANIMAL; ARTICLE; ESCHERICHIA COLI; GENE TRANSFER; GENE VECTOR; GENETICS; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; LIVER; METHODOLOGY; PHYSIOLOGY; RAT; RAT STRAIN; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BETA-GALACTOSIDASE; ESCHERICHIA COLI; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LIVER; RATS; RATS, INBRED LEW; RATS, INBRED STRAINS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 18044388031     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2000.tb02052.x     Document Type: Article

References (10)

1. Wu Y, Guo Y, Liu Y (1993) A major costimulatory molecule on antigen-presenting cell. J Exp Med 178: 1789-1793
2. Hale DA, Gottschalk R, Maki T, Monaco AP (1997) Use of CTLA4Ig in combination with conventional immunosuppressive agents to prolong allograft survival. Transplantation 64: 897-900
3. Yin DP, Sankary HN, Chong AS, Blinder L, Ma LL, Williams JW (1997) Effect of anti-CD4 monoclonal antibody combined with human CTLA4Ig on the survival of hamster liver and heart xenografts in Lewis rats. Transplantation 64: 317-321
4. Ishibashi S, Browns MS, Goldstein JL (1993) Hypercholesterolemia in low-density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 536-537
5. Ono K, Lindsey ES (1969) Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 7: 225-229
6. Miyake S, Makimura M, Kanegae Y, Harada S, Sato Y, Takamori K, Tokuda C, Saito I (1996) Efficient generation of recombinant adenovirus using adenovirus DNA - terminal protein complex and a cosmid bearing full-length virus genome. Proc Natl Acad Sci USA 93: 1320-1324
7. Linsley PS, Wallace PM, Johnson J, Gibson MG, Greece JL, Ledbetter JA, Singh C, Tepper MA (1992) Immunosuppression in vivo by a soluble form of the CTLA-4 T-cell activation molecule. Science 257: 792-795
8. Namii Y, Hayashi S, Yokoyama I, Kobayashi T, Yasutomi M, Nagasaka T, Uchida K, Hamada H, Takagi H (1997) Evidence that the adenoviral vector containing the CTLA4-Ig gene improves transgene expression and graft survival. Transplant Proc 29: 1738-1739
9. Olthoff KM, Judge TA, Gelman AE, Shen XD, Hancock WW, Turka LA, Shaked A (1998) Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med 4: 194-200
10. Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91: 4407-4411