The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity

Bulletin of Experimental Biology and Medicine

Volumn 131, Issue 4, 2001, Pages 315-317

  Zozulya, A A ^a   Kost, N V ^a   Sokolov, O Yu ^a   Gabaeva, M V ^a   Grivennikov, I A ^a,b   Andreeva, L N ^a,b   Zolotarev, Yu A ^a,b   Ivanov, S V ^a   Andryushchenko, A V ^a   Myasoedov, N F ^a,b   Smulevich, A B ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

Anxiety and phobic disorders; Enkephalinase inhibitors; Enkephalinases; Enkephalins; Selank

Indexed keywords

ANXIOLYTIC AGENT; BACITRACIN; ENKEPHALIN; ENKEPHALINASE INHIBITOR; ENZYME INHIBITOR; HEPTAPEPTIDE; MEMBRANE METALLOENDOPEPTIDASE; PUROMYCIN; SELANK; UNCLASSIFIED DRUG;

AGORAPHOBIA; ANXIETY NEUROSIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CLASSIFICATION; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HALF LIFE TIME; HUMAN; HYDROLYSIS; IC 50; PANIC; PHOBIA; RATING SCALE; SIDE EFFECT;

ANTI-ANXIETY AGENTS; ENKEPHALINS; HUMANS; NEPRILYSIN; NEUROTIC DISORDERS; OLIGOPEPTIDES; PHOBIC DISORDERS;

EID: 18044382285     PISSN: 00074888     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017979514274     Document Type: Article

References (9)