Structure and biological activity of heparinoid

Mini-Reviews in Medicinal Chemistry

Volumn 5, Issue 5, 2005, Pages 441-447

  Kumar, Neeraj ^b   Bentolila, A ^a   Domb, A J ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Anticoagulant; FGF release; Heparan sulfate; Heparanase inhibitors; Heparin; Heparinoid; Poly(acryl amino acid); Polyanion

Indexed keywords

ANTICOAGULANT AGENT; ARDEPARIN; BASIC FIBROBLAST GROWTH FACTOR; BEMIPARIN; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; DALTEPARIN; DERMATAN SULFATE; ENOXAPARIN; HEPARAN SULFATE; HEPARANASE; HEPARIN; HEPARINOID; HYALURONIC ACID; KERATAN SULFATE; LOW MOLECULAR WEIGHT HEPARIN; MALTOSE OLIGOSACCHARIDE; NADROPARIN; POLY(4 HYDROXY 2 PHENOXY)ACETIC ACID CO FORMALDEHYDE; POLY(ACRYLIC ACID CO 3,6 ENDOXO 1,2,3,6 TETRAHYDROPHTHALIC ACID); POLY(ACRYLIC ACID CO MALEIC ANHYRIDE); POLY(GLUCOSYLOXYETHYL METHACRYLATE)SULFATE; POLY(N ACRYL TYROSINE); POLYACETAL CARBOXYLIC ACID; POLYACRYLIC ACID; POLYMALEIC ACID; POLYSULFATED DEXTRAN; PYRAN; TINZAPARIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTICOAGULATION; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; BLEEDING; BLOOD CLOTTING DISORDER; CANCER INHIBITION; DRUG ACTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCEPHALOMYOCARDITIS VIRUS; HUMAN; IN VIVO STUDY; LUNG CARCINOMA; METASTASIS; NONHUMAN; RESTENOSIS; REVIEW; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; CORONARY RESTENOSIS; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HEPARIN; HEPARINOIDS; HEPARITIN SULFATE; HUMANS; NEOPLASM METASTASIS;

EID: 17944404920     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389557053765538     Document Type: Review

References (37)

1. Linhardt, R. J. Chem. Ind., 1991, 2, 45.
2. Capila, I.; Linhardt, R.J. Angew. Chem. Int. Ed., 2002, 41, 390.
3. Ahsan, A.; Jeske, W.; Hoppensteadt, D.; Lormeau, J. C.; Wolf, H.; Fareed, J. J. Pharm. Sci., 1995, 84, 724.
4. Linhardt, R.J.; Rice, K.G.; Kim, Y.S.; Lohse, D.L.; Wang, H.M. Biochem. J., 1988, 254, 781.
5. Yamada, S.; Sugahara, K. Trends Glycosci. Glycotechnol., 1998, 10, 95.
6. Linhardt, R.J.; Toida, T. In Carbohydrates in Drug Design; Witczak, Z.J., Nieforth, K.A., Eds.; Marcel Dekker: New York, 1997 ; pp 277-341.
7. Stringer, S.E.; Gallagher, J.T. Int. J. Biochem. Cell Biol., 1997, 29, 709.
8. Griffin, C.C.; Linhardt, R.J.; VanGorp, C.L.; Toida, T.; Hileman R.F.; Schubert, R.L.2nd Brown, S.E. Carbohydr. Res., 1995, 276, 183.
9. Alban, S.; Kraus, J.; Franz, G. Arzneim. Forsch. Drug Res., 1992, 42, 1005.
10. Hatanaka, K.; Yoshida, T.; Miyahara, S.; Sato, T.; Ono, F.; Uryu, T.; Kuzuhara, H. J. Med. Chem., 1987, 30, 810.
11. Butler, G.B. In Anionic Polymeric Drugs; Donaruma, L.G., Ottenbrite, R.M., Vogl, O., Eds.; John Wiley and Sons: New York, 1980; pp 49-210.
12. Giangrande, P. L. Int. J. Clin. Pract., 2002, 56, 615.
13. Jeske, W.P.; Walenga, J.M. Curr. Opin. Invest. Drugs, 2002, 3, 1171.
14. Mikhailov, D.; Young, H.C.; Linhardt, R.J.; Mayo, K.H. J. Biol. Chem., 1999, 274, 25317.
15. Martindale The Extra Pharmacopoeia, 30th ed.; The Pharmaceutical Press: London, 1993; pp. 227-232.
16. Pires, L., Gorin, P.A.J., Reicher, F.; Sierakowski, M.R. Carbohydrate Polymers, 2001, 46, 165.
17. Sakamoto, N., Shioya, T., Serizawa, T.; Akashi, M. Bioconjugate Chemistry, 1999, 10, 538.
18. Ottenbrite, R.M. In Biological Activities of Polymers; Carraher, C.E., Gebelin, C.G., Eds.; ACS Symposium Series 186; ACS: Washington, DC, 1982; pp 205-220.
19. Bentolila, A.; Vlodavsky, I.; Michaeli, R.I.; Kovalchuk, O.; Haloun, C.; Domb, A.J. J. Med. Chem., 2000, 43, 2591.
20. Bentolila, A.; Vlodavsky, I.; Haloun, C.; Domb, A.J. Polym. Adv. Technol., 2000, 11, 377.
21. Aazam, S. Heparin-like activity of acryl amino acid copolymers, MSc. Thesis, The Hebrew University: Jerusalem, 2002.
22. Muck, K.F.; Rolly, H.; Burg, K. Macromol. Chem., 1977, 178, 2773.
23. Gonzalez, R.G.; Blackburn, B.J.; Schleich, T. Biochim. Biophys. Acta, 1979, 562, 534.
24. Herr, A.B.; Ornitz, D.M.; Sasisekharan, R.; Venkataraman, G.; Waksman, G.J. Biological Chem., 1997, 272, 16382.
25. Benezra, M.; Ishai-Michaeli, R.; Ben-Sasson, S.A.; Vlodavsky, I. J. Cellular Physiology, 2002, 192, 276.
26. Vlodavsky, I; Friedmann, Y. J. Clin. Invest., 2001, 108, 341.
27. Miao, H.Q.; Elkin, M.; Aingorn, E.; Ishai-Michaeli, R.; Stein, C.A.; Vlodavsky, I. Int. J. Cancer, 1999, 83, 424.
28. Vlodavsky, I.; Eldor, A.; Haimovitz-Friedman, A.; Matzner, Y.; Ishai-Michaeli, R.; Levi, E.; Bashkin, P.; Lider, O.; Naparstek, Y.; Cohen, I.R.; Fuks, Z. Invasion Metastasis, 1992, 12, 112.
29. Ross, R. Nature, 1993, 362, 801.
30. Clowes, A.W.; Karnovsky, M.J. Nature, 1977, 265, 625.
31. Lever, R.; Page, C.P. Nat. Drug Disc. Rev., 2002, 1, 140.
32. Vlodavsky, I.; Miao, H.Q.; Atzmon, R.; Levi, E.; Zimmermann, J.; Bar-Shavit R.; Peretz, T.; Ben-Sasson, S.A. Thromb. Haemostasis , 1995, 74, 534.
33. Jackson, R.L.; Busch, S.J.; Cardin, A.L. Physiol. Rev., 1991, 71, 481.
34. Vlodavsky, I.; Bar-Shavit, R.; Ishai-Michaelli, R.; Bashkin, P.; Fuks, Z. Trends Biochem. Sci., 1991, 16, 268.
35. Bernfield, M.; Gotte, M.; Park, P.W.; Reizes, O.; Fitzgerald, M.L.; Lincecum, J.; Zako, M. Annu. Rev. Biochem., 1999, 68 , 729.
36. Burgess, W.H.; Maciag, T. Annu. Rev. Biochem., 1989, 58, 575.
37. Elkin, M.; Ishai-Michaeli, R.; Friedmann, Y.; Papo, O.; Pecker, I.; Vlodavsky, I. FASEB J., 2001, 15, 1661.