Evidence that a hybrid molecule of norfloxacin and biphenylacetic acid is a potent antagonist at the GABA(A) receptor

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1271-1277

  Imanishi, T ^a   Akahane, K ^b   Akaike, N ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Biphenylacetic acid; GABA induced current; Hippocampal neuron; Nystatin perforated patch clamp; Quinolones

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; DRUG METABOLITE; FELBINAC; FENBUFEN; NONSTEROID ANTIINFLAMMATORY AGENT; NORFLOXACIN; NORFLOXACIN BIPHENYLACETIC ACID DERIVATIVE; NYSTATIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CHLORIDE CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; DRUG INHIBITION; DRUG MECHANISM; ELECTRIC POTENTIAL; HIPPOCAMPUS; HYBRID; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; CHLORIDE CHANNELS; ELECTROPHYSIOLOGY; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MEMBRANE POTENTIALS; NORFLOXACIN; PATCH-CLAMP TECHNIQUES; PHENYLACETATES; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 17944404196     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00058-5     Document Type: Article

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