An overview of the pharmacokinetics of cilomilast (Arifio®), a new, orally active phosphodiesterase 4 inhibitor, in healthy young and elderly volunteers

Journal of Clinical Pharmacology

Volumn 41, Issue 9, 2001, Pages 950-958

  Zussman, B D ^a   Benincosa, L J ^a   Webber, D M ^a   Clark, D J ^a   Cowley, H ^a   Kelly, J ^a   Murdoch, R D ^a   Upward, J ^a   Wyld, P ^a   Port, A ^a   Fuder, H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CILOMILAST; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDUCED DISEASE; DRUG STRUCTURE; DRUG TOLERABILITY; FOOD DRUG INTERACTION; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STEADY STATE; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; AREA UNDER CURVE; BRONCHODILATOR AGENTS; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; MIDDLE AGED; NITRILES; PHOSPHODIESTERASE INHIBITORS;

EID: 17944377504     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700122010924     Document Type: Article

References (7)

1. Phosphodiesterase inhibitors: New opportunities for the treatment of asthma
2. Phosphodiesterase isoenzymes: Molecular targets for novel antiasthma agents
3. Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthma
4. 3H]rolipram binding activity and their relationship to emetic behaviour in the ferret
5. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: Correlation between function and interaction with a high-affinity rolipram binding site
6. Bioavailability of the oral, selective phosphodiesterase 4 inhibitor cilomilast (Ariflo®)
7. Cilomilast (SB 207499, Ariflo), a novel selective phosphodiesterase-4 inhibitor for the treatment of patients with chronic obstructive pulmonary disease