Immune mechanism of cardiac remodeling induced by antibodies against to the α1-adrenergic receptor

National Medical Journal of China

Volumn 85, Issue 9, 2005, Pages 625-629

  Zhou, Zi Hua ^a   Liao, Yu Hua ^a   Li, Liu Dong ^a   Wang, Bin ^a   Wei, Fen ^a   Wang, Min ^a   Wei, Yu Miao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Autoantibodies; Receptors, adrenergic, alpha; Ventricular remodeling

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR ANTIBODY; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; AUTOANTIBODY; COLLAGEN; MESSENGER RNA; PROTEIN C FOS; PROTEIN C JUN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART WEIGHT; IMMOBILIZATION; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEDIMENTATION RATE; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; AUTOANTIBODIES; BLOOD PRESSURE; MALE; MODELS, ANIMAL; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, INBRED SHR; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RNA, MESSENGER; VENTRICULAR REMODELING;

EID: 17844408400     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Fu ML, Herlitz H, Wallukat G, et al. Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertension. Lancet, 1994, 344:1660-1663.
2. Luther HP, Homuth V, Wallukat G. Alpha 1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension, 1997, 29:678-682.
3. Liao YH, Wei YM, Wang M, et al. Autoantibodies against AT1receptor and alpha1-adrenergic receptor in patients with hypertension. Hypertens Res,2002,25: 641-646.
4. 1-receptors in cerebral stroke caused by hypertension. J Clin Cardiol, 2003, 19: 194-196.
5. Liu HR, Zhao RR, Jiao XY, et al. Relationship of myocardial remodeling to the genesis of serum autoantibodies to cardiac beta(1)adrenoceptors and muscarinic type 2 acetylcholine receptors in rats. J Am Coll Cardiol, 2002, 39:1866-1873.
6. 1-adrenergic receptor in left ventricular hypertrophy. J Vascular Med Biology, 1990, 2: 236-246.
7. Briest W. HoIzI A, Rassler B, et al. Cardiac remodeling after long term norepinephrine treatment in rats, Cardiovasc Res, 2001, 52: 265-273.
8. Luo YS, Liao YH. Wang M, et al. Experimental study of At1receptor pepyide induced myocardial immune damage in rats. J Tongji Med University,2001,3:202-204.
9. 1-adrenoceptor in hypertension. Chin J Cardiol, 2002, 30:321-324.
10. Chomezynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-choloroform extraction. Anul Biochem, 1987, 162:156-159.
11. Nian M, Lee P, Khaper N, et al. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res, 2004, 94: 1543-1553.
12. Mari D, Di Berardino F, Cugno M. Chronic heart failure and the immune system. Clin Rev Allergy Immunol, 2002, 23: 325-340.
13. Tanoue A, Koba M, Miyawaki S, et al. Role of the alpha1 D-adrenegric receptor in the development of salt-induced hypertension. Hypertension, 2002, 40:101-106.