Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations

Arkivoc

Volumn 2005, Issue 9, 2005, Pages 200-206

  Cerrada, Verónica ^a   Matía Martín, M Paz ^a   Novella, J Luiz ^a   Alvarez Builla, Julio ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Contaminants; Fused pyridines; Loratadine; Pharmaceuticals; Synthesis

Indexed keywords

4 (8 CHLORO 2 HYDROXYMETHYL 5,6 DIHYDROBENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE)PIPERIDINE 1 CARBOXYLIC ACID ETHYL ESTER; 4 (8 CHLORO 4 HYDROXYMETHYL 5,6 DIHYDROBENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE)PIPERIDINE 1 CARBOXYLIC ACID ETHYL ESTER; ANTIHISTAMINIC AGENT; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG IMPURITY; DRUG SYNTHESIS; SUBSTITUTION REACTION; SYRUP;

EID: 17844407905     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Villani, F. J., US Patent, 1981, 4, 282, 233; Chem. Abstr. 1981, 95, 203761h.
2. Munayyer, F. J.; Guazzo, F.; Stupak, E. I.; Chaudry, I. A.; Sequeira, J. A. US Patent 2000, 6,132,758; Chem. Abstr. 2000, 133, 301192w.
3. Eyjolfsson, R. Pharmazie 2003, 58, 154.
4. Okamoto, T.; Tani, H. Chem. Pharm. Bull. 1959, 7, 130.
5. Feely, W. E.; Beavers, E. M. J. Am. Chem. Soc. 1959, 81, 4004.
6. Jung, J. C.; Jung, Y. J.; Park, O. S. Synthetic Comm. 2001, 31, 2507.
7. Both compounds were identified by HRMS. Calculated exact mass for C23H23ClN2O4 of 426.1346. Found for 11: 426.1343. Found for 12: 426.1348.