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Volumn 17, Issue 5, 2005, Pages 505-513

Non-surgical therapies of hepatocellular carcinoma

Author keywords

Chemoembolization; Hepatocellular carcinoma; Meta analysis; Percutaneous ethanol injection; Prognosis; Radio frequency ablation; Randomized controlled trials; Survival; Treatment

Indexed keywords

ACETIC ACID; ALCOHOL; ANTIANDROGEN; ANTINEOPLASTIC AGENT; CISPLATIN; CONTRAST MEDIUM; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPIRUBICIN; GELATIN SPONGE; IMMUNOMODULATING AGENT; INTERFERON; IODINATED POPPYSEED OIL; IODINE 131; MEGESTROL; MITOMYCIN C; OCTREOTIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR INHIBITOR; RECEPTOR BLOCKING AGENT; TAMOXIFEN; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY;

EID: 17844407451     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200505000-00006     Document Type: Review
Times cited : (25)

References (46)
  • 1
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: GLOBOCAN 2000
    • Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: GLOBOCAN 2000. Int J Cancer 2001; 94:153-156. The most comprehensive and up-dated statistics on cancer incidence and death worldwide.
    • (2001) Int J Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 2
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340:745-750. The most compelling data showing a rising incidence of HCC in the United States.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El Serag, H.B.1    Mason, A.C.2
  • 3
    • 1842426695 scopus 로고    scopus 로고
    • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance
    • Sangiovanni A, Del Ninno E, Fasani P, Fasani P, De Fazio C, Ronchi G, et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004; 126:1005-1014. Large European study showing that HCC is a leading cause of death among cirrhotic patients. An up-date of the cohort previously published in N Engl J Med by the authors.
    • (2004) Gastroenterology , vol.126 , pp. 1005-1014
    • Sangiovanni, A.1    Del Ninno, E.2    Fasani, P.3    Fasani, P.4    De Fazio, C.5    Ronchi, G.6
  • 4
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362:1907-1917. A comprehensive review on HCC that summarizes data on epidemiology, diagnosis and treatment. The new BCLC staging classification and treatment schedule is detailed.
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 5
    • 0032742183 scopus 로고    scopus 로고
    • Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation
    • Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 1999; 39:1434-1440. A large European study comparing the outcomes of two cohorts of patients with early HCC treated by resection or liver transplantation. First approach published according to the intention-to-treat principle.
    • (1999) Hepatology , vol.39 , pp. 1434-1440
    • Llovet, J.M.1    Fuster, J.2    Bruix, J.3
  • 6
    • 0345299824 scopus 로고    scopus 로고
    • Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
    • Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334:693-699. A landmark paper. The group from Milan established the restrictive selection criteria currently applied worldwide to select the best candidates for liver transplantation.
    • (1996) N Engl J Med , vol.334 , pp. 693-699
    • Mazzaferro, V.1    Regalia, E.2    Doci, R.3    Andreola, S.4    Pulvirenti, A.5    Bozzetti, F.6
  • 7
    • 0027300746 scopus 로고
    • Percutaneous ethanol injection therapy for hepatocellular carcinoma: Results in 146 patients
    • Shiina S, Tagawa K, Niwa Y, Unuma T, Komatsu Y, Yoshiura K, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma: results in 146 patients. Am J Roentgenol 1993; 160:1023-1028.
    • (1993) Am J Roentgenol , vol.160 , pp. 1023-1028
    • Shiina, S.1    Tagawa, K.2    Niwa, Y.3    Unuma, T.4    Komatsu, Y.5    Yoshiura, K.6
  • 8
    • 0029079899 scopus 로고
    • Hepatocellular carcinoma and cirrhosis in 746 patients: Long-term results of percutaneous ethanol injection
    • Livraghi T, Giorgio A, Marin G, Salmi a, de Sio I, Bolondi L, et al. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 1995; 197:101-108. The largest series ever published of HCC patients treated with percutaneous ethanol injection in Europe.
    • (1995) Radiology , vol.197 , pp. 101-108
    • Livraghi, T.1    Giorgio, A.2    Marin, G.3    Salmi, A.4    De Sio, I.5    Bolondi, L.6
  • 9
    • 0030629507 scopus 로고    scopus 로고
    • Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: A European experience
    • Lencioni R, Pinto F, Armillotta N, Bassi AM, Moretti M, Di Guilio M, et al. Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: a European experience. Eur Radiol 1997; 7:514-519.
    • (1997) Eur Radiol , vol.7 , pp. 514-519
    • Lencioni, R.1    Pinto, F.2    Armillotta, N.3    Bassi, A.M.4    Moretti, M.5    Di Guilio, M.6
  • 10
    • 0032187919 scopus 로고    scopus 로고
    • Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: Multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection
    • Sakamoto M, Hirohashi S. Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection. Jp J Clin Oncol 1998; 28:604-608. A multi-institutional paper from Japan reporting the best outcomes of patients with 'very early HCC' treated by percutaneous ethanol injection.
    • (1998) Jp J Clin Oncol , vol.28 , pp. 604-608
    • Sakamoto, M.1    Hirohashi, S.2
  • 11
    • 0033792095 scopus 로고    scopus 로고
    • Treatment of small hepatocellular carcinoma with percutaneous ethanol injection: A validated prognostic model
    • Orlando A, D'Antoni A, Camma C. Treatment of small hepatocellular carcinoma with percutaneous ethanol injection: a validated prognostic model. Am J Gastroenterol 2000; 95:2921-2927.
    • (2000) Am J Gastroenterol , vol.95 , pp. 2921-2927
    • Orlando, A.1    D'Antoni, A.2    Camma, C.3
  • 12
    • 0033646209 scopus 로고    scopus 로고
    • Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan
    • Arii S, Yamaoka Y, Futagawa S, lnoue K, Kobayashi K, Kojiro M, et al. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan. Hepatology 2000; 32:1224-1229. A national survey from Japan that provides the most comprehensive set of outcomes in HCC patients published up to now. It gives the opportunity to compare survival rates of patients with early HCC treated by resection, percutaneous treatments and arterial embolization as the first-line option.
    • (2000) Hepatology , vol.32 , pp. 1224-1229
    • Arii, S.1    Yamaoka, Y.2    Futagawa, S.3    Lnoue, K.4    Kobayashi, K.5    Kojiro, M.6
  • 13
    • 9744265831 scopus 로고    scopus 로고
    • Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma
    • Sala M, Llovet JM, Vilana R, Bianchi L, Sole M, Ayuso C, et al. Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma. Hepatology 2004; 40:1352-1360. The first study identifying treatment response as an independent predictor of survival in a series of HCC patients treated by percutaneous therapies. This represents the strongest evidence supporting the suggestion that complete response may lead to survival advantages.
    • (2004) Hepatology , vol.40 , pp. 1352-1360
    • Sala, M.1    Llovet, J.M.2    Vilana, R.3    Bianchi, L.4    Sole, M.5    Ayuso, C.6
  • 14
    • 1242307267 scopus 로고    scopus 로고
    • Multimodal image-guide tailored therapy of early and intermediate hepatocellular carcinoma: Long-term survival in the experience of a single radiologic referral center
    • Livraghi T, Meloni F, Morabito A, Vettori C. Multimodal image-guide tailored therapy of early and intermediate hepatocellular carcinoma: long-term survival in the experience of a single radiologic referral center. Liver Transpl 2004; 10 (suppl 1):S98-S106.
    • (2004) Liver Transpl , vol.10 , Issue.1 SUPPL.
    • Livraghi, T.1    Meloni, F.2    Morabito, A.3    Vettori, C.4
  • 15
    • 0029745063 scopus 로고    scopus 로고
    • Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer
    • Rossi S, Di Stasi M, Buscarini E, Quaretti P, Garbagnati F, Squassante L, et al. Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. Am J Roentgenol 1996; 167:759-768. The seminal paper reporting encouraging results with percutaneous radio frequency as a primary treatment of non-surgical HCC.
    • (1996) Am J Roentgenol , vol.167 , pp. 759-768
    • Rossi, S.1    Di Stasi, M.2    Buscarini, E.3    Quaretti, P.4    Garbagnati, F.5    Squassante, L.6
  • 16
    • 0034879778 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation of small hepatocellular carcinoma: Long-term results
    • Buscarini L, Buscarini E, Di Stasi M. Percutaneous radiofrequency ablation of small hepatocellular carcinoma: long-term results. Eur Radiol 2001; 11:914-921.
    • (2001) Eur Radiol , vol.11 , pp. 914-921
    • Buscarini, L.1    Buscarini, E.2    Di Stasi, M.3
  • 17
    • 0031606091 scopus 로고    scopus 로고
    • Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma: Local therapeutic effect and long-term survival rate
    • Lencioni R, Paolicchi A, Moretti M, Pinto F, Armillotta N, Di Guilio M, et al. Combined transcatheter arterial chemoembolization and percutaneous ethanol injection for the treatment of large hepatocellular carcinoma: local therapeutic effect and long-term survival rate. Eur Radiol 1998; 8:439-444.
    • (1998) Eur Radiol , vol.8 , pp. 439-444
    • Lencioni, R.1    Paolicchi, A.2    Moretti, M.3    Pinto, F.4    Armillotta, N.5    Di Guilio, M.6
  • 18
    • 0031893533 scopus 로고    scopus 로고
    • The long term efficacy of combined transcatheter arterial embolization and percutaneous ethanol injection in the treatment of patients with large hepatocellular carcinoma and cirrhosis
    • Tanaka K, Nakamura S, Numata K, Kondo M, Morita K, Kitamura T, et al. The long term efficacy of combined transcatheter arterial embolization and percutaneous ethanol injection in the treatment of patients with large hepatocellular carcinoma and cirrhosis. Cancer 1998; 82:78-85.
    • (1998) Cancer , vol.82 , pp. 78-85
    • Tanaka, K.1    Nakamura, S.2    Numata, K.3    Kondo, M.4    Morita, K.5    Kitamura, T.6
  • 19
    • 0031887222 scopus 로고    scopus 로고
    • Cryotherapy for primary liver cancer
    • Zhou XD, Tang ZY. Cryotherapy for primary liver cancer. Semin Surg Oncol 1998; 14:171-174.
    • (1998) Semin Surg Oncol , vol.14 , pp. 171-174
    • Zhou, X.D.1    Tang, Z.Y.2
  • 20
    • 0035192214 scopus 로고    scopus 로고
    • Pacella laser thermal ablation in the treatment of small hepatocellular carcinoma: Results in 74 patients
    • Pacella CM, Bizzarri G, Magnolfi F, Cecconi P, Caspani G, Anelli V, et al. Pacella laser thermal ablation in the treatment of small hepatocellular carcinoma: results in 74 patients. Radiology 2001; 221:712-720.
    • (2001) Radiology , vol.221 , pp. 712-720
    • Pacella, C.M.1    Bizzarri, G.2    Magnolfi, F.3    Cecconi, P.4    Caspani, G.5    Anelli, V.6
  • 21
    • 0038512167 scopus 로고    scopus 로고
    • Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: Results in 234 patients
    • Dong B, Liang P, Yu X, Su L, Su L, Yu D, et al. Percutaneous sonographically guided microwave coagulation therapy for hepatocellular carcinoma: results in 234 patients. Am J Roentgenol 2003; 180:1547-1555.
    • (2003) Am J Roentgenol , vol.180 , pp. 1547-1555
    • Dong, B.1    Liang, P.2    Yu, X.3    Su, L.4    Su, L.5    Yu, D.6
  • 22
    • 0031962297 scopus 로고    scopus 로고
    • Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma
    • Ohnishi K, Yoshioka H, Ito S, Fujiwara K. Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma. Hepatology 1998; 27:67-72. The sole randomized controlled trial comparing percutaneous ethanol injection with percutaneous injection of acetic acid. Advantages favouring the latter have been questioned.
    • (1998) Hepatology , vol.27 , pp. 67-72
    • Ohnishi, K.1    Yoshioka, H.2    Ito, S.3    Fujiwara, K.4
  • 23
    • 0030660357 scopus 로고    scopus 로고
    • Predictive factors of survival and intrahepatic recurrence of hepatocellular carcinoma in cirrhosis after percutaneous ethanol injection: Analysis of 71 patients
    • Castellano L, Calandra M, Del Vecchio Blanco C, de Sio I. Predictive factors of survival and intrahepatic recurrence of hepatocellular carcinoma in cirrhosis after percutaneous ethanol injection: analysis of 71 patients. J Hepatol 1997; 27:862-870.
    • (1997) J Hepatol , vol.27 , pp. 862-870
    • Castellano, L.1    Calandra, M.2    Del Vecchio Blanco, C.3    De Sio, I.4
  • 24
    • 0035397554 scopus 로고    scopus 로고
    • Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy
    • Pompili M, Rapaccini GL, Covino M, Pignataro G, Caturelli E, Siena DA, et al. Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy. Cancer 2001; 92:126-135.
    • (2001) Cancer , vol.92 , pp. 126-135
    • Pompili, M.1    Rapaccini, G.L.2    Covino, M.3    Pignataro, G.4    Caturelli, E.5    Siena, D.A.6
  • 25
    • 0032857003 scopus 로고    scopus 로고
    • Local ablation therapy for hepatocellular carcinoma
    • Okada S. Local ablation therapy for hepatocellular carcinoma. Semin Liver Dis 1999; 19:323-328. A comprehensive overview of percutaneous treatments for HCC.
    • (1999) Semin Liver Dis , vol.19 , pp. 323-328
    • Okada, S.1
  • 26
    • 0038714350 scopus 로고    scopus 로고
    • Small hepatocellular carcinoma in cirrhosis: Randomized controlled trial of radiofrequency termal ablation versus percutaneous ethanol injection
    • Lencioni R, Allgaier HP, Cioni D, Olschewski M, Deibert P, Crocetti L, et al. Small hepatocellular carcinoma in cirrhosis: randomized controlled trial of radiofrequency termal ablation versus percutaneous ethanol injection. Radiology 2003; 228:235-240. The single radomized controlled trial published comparing percutaneous ethanol injection with radio frequency ablation in a serie of patients with small non-surgical HCC. No survival benefits were identified, although the authors suggested advantages in terms of local control of the disease favouring radio frequency.
    • (2003) Radiology , vol.228 , pp. 235-240
    • Lencioni, R.1    Allgaier, H.P.2    Cioni, D.3    Olschewski, M.4    Deibert, P.5    Crocetti, L.6
  • 27
    • 0032975767 scopus 로고    scopus 로고
    • Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection
    • Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 1999; 210:655-661.
    • (1999) Radiology , vol.210 , pp. 655-661
    • Livraghi, T.1    Goldberg, S.N.2    Lazzaroni, S.3    Meloni, F.4    Solbiati, L.5    Gazelle, G.S.6
  • 28
    • 0034541431 scopus 로고    scopus 로고
    • Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply
    • Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchiano A, Fornari F, et al. Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology 2000; 217:119-126.
    • (2000) Radiology , vol.217 , pp. 119-126
    • Rossi, S.1    Garbagnati, F.2    Lencioni, R.3    Allgaier, H.P.4    Marchiano, A.5    Fornari, F.6
  • 29
    • 0035028475 scopus 로고    scopus 로고
    • Increased risk of tumor seeding after radiofrequency thermal ablation for single hepatocellular carcinoma
    • Llovet JM, Vilana R, Bru C, Bianchi L, Salmeron JM, Boix L, et al. Increased risk of tumor seeding after radiofrequency thermal ablation for single hepatocellular carcinoma. Hepatology 2001; 33:1124-1129.
    • (2001) Hepatology , vol.33 , pp. 1124-1129
    • Llovet, J.M.1    Vilana, R.2    Bru, C.3    Bianchi, L.4    Salmeron, J.M.5    Boix, L.6
  • 30
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 2003; 37:429-442. The most comprehensive systematic review of randomized controlled trials in HCC published up to now. A meta-analysis of the trials assessing chemoembolization demonstrates survival benefits in a selected group of patients.
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 31
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
    • Llovet JM, Real MI, Montana X, Planas R, Coll S, Aponte J, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002; 359:1734-1739. This is the largest randomized controlled trial in the West assessing embolization for non-surgical HCC. The study was stopped because survival benefits favouring the treatment arm (chemoembolization with doxorubicin) were identified in comparison to conservative management.
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montana, X.3    Planas, R.4    Coll, S.5    Aponte, J.6
  • 32
    • 0036237822 scopus 로고    scopus 로고
    • Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    • Lo CM, Ngan H, Tso WK, et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002; 35:1164-1171. A positive randomized controlled trial from Hong Kong demonstrating survival benefits favouring the treatment arm (chemoembolization with cisplatin) in comparison to conservative management.
    • (2002) Hepatology , vol.35 , pp. 1164-1171
    • Lo, C.M.1    Ngan, H.2    Tso, W.K.3
  • 33
    • 0029001687 scopus 로고
    • A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma
    • Group d'Etude et de Traitment du Carcinome Hépatocellulaire. A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 1995; 332: 1256-1261. A negative randomized controlled trial from France, in which chemoembolization reduced tumour progression without an impact on survival.
    • (1995) N Engl J Med , vol.332 , pp. 1256-1261
  • 34
    • 0031801297 scopus 로고    scopus 로고
    • Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: Results of a randomized, controlled trial in a single institution
    • Bruix J, Llovet JM, Castells A, Montana X, Bru C, Ayuso MC, et al. Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomized, controlled trial in a single institution. Hepatology 1998; 127:1578-1583. A negative randomized controlled trial comparing arterial embolization (gelfoam and coils) versus conservative management.
    • (1998) Hepatology , vol.127 , pp. 1578-1583
    • Bruix, J.1    Llovet, J.M.2    Castells, A.3    Montana, X.4    Bru, C.5    Ayuso, M.C.6
  • 36
    • 0026592922 scopus 로고
    • Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma - A comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study)
    • The Cooperative Study Group for Liver Cancer Treatment of Japan
    • Kawai S, Okamura J, Ogawa M, Ohashi Y, Tani M, Inoue J, et al. Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma - a comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Cancer Chemother Pharmacol 1992; 31: S1-S6.
    • (1992) Cancer Chemother Pharmacol , vol.31
    • Kawai, S.1    Okamura, J.2    Ogawa, M.3    Ohashi, Y.4    Tani, M.5    Inoue, J.6
  • 37
    • 0028035352 scopus 로고
    • Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study
    • Chang JM, Tzeng WS, Pan HB, Yang CF, Lai KH. Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study. Cancer 1994; 74:2449-2453.
    • (1994) Cancer , vol.74 , pp. 2449-2453
    • Chang, J.M.1    Tzeng, W.S.2    Pan, H.B.3    Yang, C.F.4    Lai, K.H.5
  • 38
    • 0031111899 scopus 로고    scopus 로고
    • Prospective and randomized trial of lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma: A comparison of epirubicin and doxorubicin (second cooperative study)
    • The Cooperative Study Group for Liver Cancer Treatment of Japan
    • Kawai S, Tani M, Okamura J, Ogawa M, Ohashi Y, Monden M, et al. Prospective and randomized trial of lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma: a comparison of epirubicin and doxorubicin (second cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Semin Oncol 1997; 24:S6.
    • (1997) Semin Oncol , vol.24
    • Kawai, S.1    Tani, M.2    Okamura, J.3    Ogawa, M.4    Ohashi, Y.5    Monden, M.6
  • 39
    • 0029127746 scopus 로고
    • Treatment of hepatocellular carcinoma with tamoxifen: A double-blind placebo-controlled trial in 120 patients
    • Castells A, Bruix J, Bru C, Ayuso C, Roca M, Boix L, et al. Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients. Gastroenterology 1995; 109:917-922. The largest double-blind, placebo controlled, randomized controlled trial discarding survival effects of tamoxifen in patients with advanced HCC.
    • (1995) Gastroenterology , vol.109 , pp. 917-922
    • Castells, A.1    Bruix, J.2    Bru, C.3    Ayuso, C.4    Roca, M.5    Boix, L.6
  • 40
    • 1242329819 scopus 로고    scopus 로고
    • Focus on dysplastic nodules and early hepatocellular carcinoma: An eastern point of view
    • Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: an eastern point of view. Liver Transpl 2004; 10:S3-S8. Very informative manuscript. Tumour dissemination already occurs at the early stages in HCC (<2 cm), as in other neoplasms.
    • (2004) Liver Transpl , vol.10
    • Kojiro, M.1
  • 41
    • 0034856294 scopus 로고    scopus 로고
    • Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference
    • Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference. J Hepatol 2001; 35:421-430. The first consensus conference on HCC endorsed by the European Association for the Study of the Liver (EASL). A panel of experts provided guidelines for surveillance and recall policy, along with a set of non-invasive criteria for the diagnosis of this neoplasm.
    • (2001) J Hepatol , vol.35 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3    Beaugrand, M.4    Lencioni, R.5    Burroughs, A.K.6
  • 43
    • 0037218312 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Present status and future prospects
    • Llovet JM, Beaugrand M. Hepatocellular carcinoma: Present status and future prospects. J Hepatol 2003; 38 (suppl 1):S136-S149.
    • (2003) J Hepatol , vol.38 , Issue.1 SUPPL.
    • Llovet, J.M.1    Beaugrand, M.2
  • 44
    • 0003120252 scopus 로고    scopus 로고
    • Cancer of the liver and biliary tree
    • DeVita VT, Hellman S, Rosenberg S (editors): Phildelphia: Lippincort Williams & Wilkins
    • Fong Y, Kemeny N, Lawrence T. Cancer of the liver and biliary tree. In: DeVita VT, Hellman S, Rosenberg S (editors): Cancer: Principles and Practices of Oncology. Phildelphia: Lippincort Williams & Wilkins; 2001, pp. 1162-1204.
    • (2001) Cancer: Principles and Practices of Oncology , pp. 1162-1204
    • Fong, Y.1    Kemeny, N.2    Lawrence, T.3
  • 45
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson S, Grisham J. Molecular pathogenesis of human hepatocellular carcinoma. Nature Genetics 2002; 31:339-346. Probably the most informative overview published of the current knowledge in the pathogenesis of HCC.
    • (2002) Nature Genetics , vol.31 , pp. 339-346
    • Thorgeirsson, S.1    Grisham, J.2
  • 46
    • 0032532086 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantation
    • Mor E, Kaspa RT, Sheiner P, Schwarte M. Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantation. Ann Intern Med 1998; 129:643-653.
    • (1998) Ann Intern Med , vol.129 , pp. 643-653
    • Mor, E.1    Kaspa, R.T.2    Sheiner, P.3    Schwarte, M.4


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