Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats

Pharmacology

Volumn 74, Issue 1, 2005, Pages 23-30

  Schulingkamp, Robert J ^a   Aloyo, Vincent ^c   Tallarida, Ronald J ^b   Raffa, Robert B ^a,b  

^a TEMPLE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenoceptors; Affinity; Aorta; Diabetes; Receptor number; Streptozotocin

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOSE; PHENOXYBENZAMINE; PHENYLEPHRINE; PRAZOSIN; STREPTOZOCIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BODY WEIGHT DISORDER; CONTROLLED STUDY; DISEASE COURSE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; ISOLATED ARTERY; MALE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; THORACIC AORTA; ANIMAL; BINDING SITE; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EXPERIMENTAL DIABETES MELLITUS; IN VITRO STUDY; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT; TIME; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; BINDING SITES; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOMETRIC CONTRACTION; MALE; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; PRAZOSIN; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; STREPTOZOCIN; TIME FACTORS;

EID: 17844380801     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083211     Document Type: Article

References (28)

1. Palumbo PJ, Elveback LR, Whisnant JP: Neurologic complications of diabetes mellitus: Transient ischemic attack, stroke, and peripheral neuropathy. Adv Neurol 1978;19:593-601.
2. Kannel WB, D'Agostino RB, Wilson PW, Belanger AJ, Gagnon DR: Diabetes, fibrinogen and risk of cardiovascular disease, the Framingham experience. Am Heart J 1990;120:672-676.
3. Greene DA, Sima AF, Pfeifer MA, Albers JW: Diabetic neuropathy. Annu Rev Med 1990;41:303-317.
4. Friedman EA: Diabetic nephropathy: Progress in treatment, potential for prevention. Diabetes Spectrum 1989;2:85-95.
5. Lehmann ED, Gosling RG, Sonksen PH: Arterial wall compliance in diabetes. Diabetic Med 1992;9:114-119.
6. McNeill JH: Experimental Models of Diabetes. Boca Raton, CRC Press, 1999.
7. Abebe W, Harris KH, MacLeod KM: Enhanced contractile responses of arteries from diabetic rats to alpha-1-adrenoceptor stimulation in the absence and presence of extracellular calcium. J Cardiovasc Pharmacol 1990; 16:239-248.
8. Furchgott RF: The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes; in Harper NJ, Simmonds AB (eds): Advances in Drug Research. New York, Academic Press, 1966, vol 3, pp 21-55.
9. Tallarida RJ, Murray RG: Manual of Pharmacologic Calculations with Computer Programs, ed 2. New York, Springer, 1987.
10. Arunlakshana O, Schild HO: Some quantitative uses of drug antagonists. Br J Pharmacol 1959;14:48-58.
11. Munson PJ, Rodbard D: Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 1980;107:220-239.
12. Uchigata Y, Yamamoto H, Kawamura A, Okamoto H: Protection by superoxide dismutase, catalase and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem 1982;257:6084-6088.
13. Owen MP, Carrier GO: Calcium dependence of norepinephrine-induced vascular contraction in experimental diabetes. J Pharmacol Exp Ther 1980;212:253-258.
14. Harris KH, MacLeod KM: Influences of the endothelium on contractile responses of arteries from diabetic rats. Eur J Pharmacol 1988;153:55-64.
15. Legan E: Effects of streptozotocin-induced hyperglycemia on agonist-stimulated phosphatidylinositol turnover in rat aorta. Life Sci 1989;45:371-378.
16. Ramanadham S, Lyness WH, Tenner TE Jr: Alterations in aortic and tail artery reactivity to agonists after streptozotocin treatment. Can J Physiol Pharmacol 1984;62:418-423.
17. Head RJ, Longhurst PA, Panek RL, Stitzel RE: A contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit. Br J Pharmacol 1987;91:275-286.
18. Scarborough NL, Carrier GO: Nifedipine and alpha adrenoceptors in rat aorta II Role of extracellular calcium in enhanced alpha-2 adrenoceptor-mediated contraction in diabetes. J Pharmacol Exp Ther 1984;231:603-609.
19. MacLeod KM: The effects of insulin treatment on changes in vascular reactivity in chronic experimental diabetes. Diabetes 1985;34:1160-1167.
20. Oyama Y, Kawasaki H, Hattori Y, Kanno M: Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur J Pharmacol 1986;131:75-78.
21. Mulhern M, Docherty JR: Effects of experimental diabetes on the responsiveness of rat aorta. Br J Pharmacol 1989;97:1007-1012.
22. Kamata K, Miyata N, Kasuya Y: Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naïve and streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 1989;249:890-894.
23. Hart JL, Freas W, McKenzie JE, Muldoon SM: Adrenergic nerve function and contractile activity of the caudal artery of the streptozotocin diabetic rat. J Auton Nerv Syst 1988;25:49-57.
24. Testa R, Guarneri L, Poggesi E, Simonazzi I, Taddei C, Leonardi A: Mediation of noradrenaline-induced contractions of rat aorta by the alpha-1b-adrenoceptor subtype. Br J Pharmacol 1995;114:745-750.
25. Deng XF, Chemtob S, Varma DR: Characterization of alpha-1D-adrenoceptor subtype in rat myocardium, aorta and other tissues. Br J Pharmacol 1996;119:269-276.
26. Abebe W, MacLeod KM: Enhanced arterial contractility to noradrenaline in diabetic rats is associated with increased phosphoinositide metabolism. Can J Physiol Pharmacol 1991;69:355-361.
27. Abebe W, MacLeod KM: Influence of diabetes on norepinephrine-induced inositol 1,4,5-trisphosphate levels in rat aorta. Life Sci 1991;49:PL85-PL90.
28. Okumura K, Nishiura T, Awaji Y, Kondo J, Hashimoto H, Ito T: 1,2-Diacylglycerol content and its fatty acid composition in thoracic aorta of diabetic rats. Diabetes 1991;40:820-824.