Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen

Immunology

Volumn 115, Issue 1, 2005, Pages 34-41

  Ismail, Nahed ^a,c   Basten, Antony ^b   Briscoe, Helen ^b   Bretscher, Peter A ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b CENTENARY INSTITUTE   (Australia)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Cell mediated versus humoral immunity; T cell T cell interactions; Th1 Th2 pathways

Indexed keywords

EPITOPE;

ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOMODULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ANTIGENS; EPITOPES, T-LYMPHOCYTE; ERYTHROCYTES; IMMUNITY, CELLULAR; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MURAMIDASE; SHEEP; TH1 CELLS; TH2 CELLS;

EID: 17844377885     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02128.x     Document Type: Article

References (29)

1. Pearson MN, Raffel S. Macrophage-digested antigen as inducer of delayed type hypersensitivity. J Exp Med 1971; 133:494-505.
2. Parish CR. The relationship between cell-mediated and humoral immunity. Transplant Rev 1972; 13:35-66.
3. Bretscher PA. Hypothesis: on the control between cell-mediated and humoral immunity. Cell Immunol 1974 1972; 31:171-95.
4. Bretscher PA. Significance and mechanisms of cellular regulation of the immune response. Fed Proc 1981; 40:1473-8.
5. Bretscher PA. The regulatory functions of CD4+ and CD8+ T-cell subsets in immune class regulation. Res Immunol 1991; 142:45-9.
6. Salvin SB. Occurrence of delayed type hypersensitivity during the development of Arthus type hypersensitivity. J Exp Med 1958; 107:109-20.
7. Ismail N, Bretscher PA. The Th1/Th2 nature of concurrent immune responses to unrelated antigens can be independent. J Immunol 1999; 163:4842-50.
8. Actor JK, Shirai M, Kullberg MC, Buller ML, Sher A, Berzovsky JA. Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci USA 1993; 90:948-53.
9. Pearce EJ, Casper P, Grzych JM, Lewis FA, Sher A. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasite helminth. J Exp Med 1991; 173:159-66.
10. Tucker MJ, Bretscher PA. T cells cooperating in the induction of delayed type hypersensitivity act via the linked recognition of antigenic determinants. J Exp Med 1982; 155:1037-49.
11. Gerloni M, Xiong S, Mukerjee S, Schoenberger SP, Croft M, Zanetti M. Functional cooperation between T helper determinants. Proc Natl Acad Sci USA 2000; 97:13269-74.
12. Goodnow CC. Transgenic mice and analysis of B cell tolerance. Annu Rev Immunol 1992; 10:489-518.
13. Power CA, Grand CL, Ismail N, Peters NC, Yurkowski DP, Bretscher PA. A valid ELISPOT assay for enumeration of ex vivo, antigen-specific, IFNgamma-producing T cells. J Immunol Meth 1999; 227:99-107.
14. Cunningham AJ, Szenberg A. Further improvement in the plaque technique for detecting antibody forming cells. Immunology 1968; 14:599-608.
15. Ramshaw IA, Bretscher PA, Parish CR. Regulation of the immune response. I. Suppression of delayed type hypersensitivity by T cells from mice expressing humoral immunity. Eur J Immunol 1976; 6:674-9.
16. Manca F, Clarke JA, Miller A, Sercarz EE, Shastri N. A limited region with hen egg-white lysozyme serves as the focus for a diversity of T cell clones. J Immunol 1984; 133:2075-83.
17. Claman HN, Chaperon EA, Triplett RF. Immunocompetence of transferred thymus-marrow cell combinations. J Immunol 1966; 97:828-32.
18. Keene JA, Forman J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med 1982; 155:768-82.
19. Pilarski LM. A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors. J Exp Med 1971; 456:709-25.
20. Bretscher PA. Regulation of the class of immune response induced by antigen. I. Specific T cells switch the in vivo response from a cell-mediated to humoral mode. Cell Immunol 1983; 81:345-56.
21. Ismail N, Bretscher PA. More antigen-dependent CD4 T cell/CD4 T cell interactions are required for the primary generation of Th2 than of Th1 cells. Eur J Immunol 2001; 31:1767-71.
22. Ramshaw IA, Bretscher PA, Parish CR. Regulation of the immune response. II. Repressor T cells in cyclophosphamide-induced tolerant mice. Eur J Immunol 1977; 7:180-7.
23. Min B, McHugh R, Sempowski GD, Mackall C, Foucras G, Paul WE. Neonates support lymphopenia-induced proliferation. Immunity 2003; 18:131-40.
24. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2:151-61.
25. Boonstra A, Asselin-Paturel C, Gilliet M, Grain C, Trinchieri G, Liu Y-J, O'Garra A. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J Exp Med 2003; 197:101-9.
26. Bretscher PA, Ismail N, Menon JN, Power CA, Uzonna J, Wei G. Vaccination against and treatment of tuberculosis, the leishmaniases and AIDS. Perspectives from basic immunology and immunity to chronic intracellular infections. Cellular Mol Life Sci 2001; 58:1879-96.
27. Constant S, Pfeiffer C, Woodward A, Pasqualini T, Bottomly K. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med 1995; 182: 1591-6.
28. Jenkins MK, Pardoll DM, Mizuguchi J, Quill H, Schwartz RH. T cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol Rev 1987; 95:113-35.
29. Adams E, Basten A, Goodnow CC. Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice. Proc Natl Acad Sci USA; 87: 5687-91.