Problems of cyclosporine absorption profiling using C2-monitoring

European Journal of Medical Research

Volumn 10, Issue 4, 2005, Pages 175-178

  Schuetz, Manuela ^a   Einecke, G ^a   Mai, I ^a   Neumayer, H H ^a   Glander, P ^a   Waiser, J ^a   Fritsche, L ^a   Budde, K ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

C2 monitoring; Cyclosporine

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BASILIXIMAB; CYCLOSPORIN A; MYCOPHENOLIC ACID; STEROID; TACROLIMUS;

ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; DOSE KIDNEY FUNCTION RELATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EXPOSURE; DRUG MIXTURE; DRUG MONITORING; DRUG WITHDRAWAL; FOLLOW UP; GRAFT SURVIVAL; HUMAN; KIDNEY BIOPSY; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; LIVER TOXICITY; MICROEMULSION; MULTICENTER STUDY; NEPHROTOXICITY; OUTCOMES RESEARCH; POSTOPERATIVE PERIOD; PREDICTION; VALIDATION PROCESS;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; COMPLEMENT C2; CYCLOSPORINE; DRUG MONITORING; DRUG THERAPY, COMBINATION; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERNATIONAL AGENCIES; INTESTINAL ABSORPTION; KIDNEY; KIDNEY TRANSPLANTATION; MYCOPHENOLIC ACID; RECOMBINANT FUSION PROTEINS; STEROIDS;

EID: 17844376527     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Neumayer HH, Budde K, Farber L, Haller P, Kohnen R, Maibucher A, Schuster A, Vollmar J, Waiser J, Luft FC (1996) Conversion to microemulsion cyclosporine in stable renal transplant patients: Results after one year. Clinical Nephrology 45: 326-331
2. Lindholm A, Kahan BD (1993) Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation. Clin Pharmacol Ther 54: 205-218
3. Cantarovich M, Besner JG, Barkun JS, Elstein E, Loertscher R (1998) Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy. Clin Transplant 12: 243-249
4. Keown P, Landsberg D, Halloran P, Shoker A, Rush D, Jeffrey J et al (1996) A randomised, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulsion in stable renal graft recipients. Report of the Canadian Neoral Renal Transplantation Study Group. Transplantation 62: 1744-1752
5. Pescovitz MD, Barbeito R (2002) Two-hour post-dose cyclosporine level is a better predictor than trough level of acute rejection of renal allografts. Clin Transplant 16: 378-382
6. Talaulikar GS, John GT, Selvakumar R, Job V, Thomas PP, Jakob CK (2003) Pre- and postrenal transplantation pharmacokinetics of cyclosporine microemulsion. Transplantion Proceedings 35: 1295-1297
7. Grevel J, Post BK, Kahan BD (1993) Michaelis-Menten kinetics determine cyclosporine steady-state concentrations: a population analysis in kidney transplant patients. Clin Pharmcol Ther 53: 651-660
8. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB (1997) Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 62: 248-260
9. Brunner LJ, Bennett WM, Koop DR (1998) Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner. Kidney Int 54: 216-223
10. Mahalati K, Belitsky P, West K, Kiberd B, Fraser A, Sketris I, Macdonald AS, McAlister V, Lawen J (2001) Approaching the therapeutic window for cyclosporine in kidney transplantation: A prospective study. J Am Soc Nephrol 12: 828-833