Long-term follow-up of lymphocyte populations and cellular cytokine production in patients with chronic graft-versus-host disease treated with extracorporeal photopheresis

Haematologica

Volumn 90, Issue 4, 2005, Pages 565-567

  Da Silva, Maria Gomes ^a   Neto, Lara Ferreira ^a   Guimarães, António ^a   Machado, Alexandra ^a   Parreira, António ^a   Abecasis, Manuel ^a  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

Author keywords

CVHD; Cytokines; ECP

Indexed keywords

CYTOKINE; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; CELL COUNT; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DENDRITIC CELL; EQUIPMENT; EXTRACORPOREAL PHOTOPHERESIS; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LYMPHOCYTE SUBPOPULATION; MONOCYTE; PHOTOIMMUNOTHERAPY; PHOTOTHERAPY; PUVA; TH1 CELL;

ADOLESCENT; ADULT; CHRONIC DISEASE; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; GRAFT VS HOST DISEASE; HUMANS; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; PHOTOPHERESIS; TH1 CELLS; TH2 CELLS;

EID: 17844376237     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Greinix H, Volc-Platzer B, Rabitsch W, Gmeinhart B, Guevara-Pineda C, Kalhs P, et al. Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 1998;92:3098-104.
2. Apisarnthanarax N, Donato M, Körbling M, Couriel D, Gajewski J, Giralt S, et al. Extracorporal photopheresis therapy in the management of steroid-refractory or steroid dependent cutaneous chronic graft-versus-host disease after allogeneic bone marrow transplantation: feasibility and results. Bone Marrow Transplant 2003;31:459-65.
3. Seaton ED, Szydlo RM, Kanfer E, Apperley JF, Russell-Jones R. Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft versus host disease and analysis of predictors of response. Blood 2003;102:1217-23.
4. Bladon J, Taylor PC. Extracorporeal photopheresis induces apoptosis in the lymphocytes of cutaneous T-cell lymphoma and graft-versus-host disease patients. Br J Haematol 1999;107:707-11.
5. high regulatory T cells. Blood 2004;103:2410-6.
6. Gorgun G, Miller KB, Foss FM. Immunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host-disease. Blood 2002;100:941-7.
7. Tokura Y, Seo N, Yagi H, Wakita H, Moriwaki S, Furukawa F, et al. Treatment of T lymphocytes with 8-methoxipsoralen plus ultraviolet A light induces transient but biologically active Th1 skewing cytokine production. J Invest Dermatol 1999;113:202-8.
8. Di Renzo M, Rubegni P, De Aloe G, Paulesu L, Pasqui AL, Andreassi L, et al. Extracorporeal photochemotherapy restores Th1/Th2 imbalance in patients with early stage cutaneous T cell lymphoma. Immunology 1997;92:99-103.
9. Tanaka J, Imamura M, Kasai M, Hashino S, Kobayashi S, Noto S, et al. Th2 cytokines (IL4, IL10, and IL13) and IL12 mRNA expression by concanavalin A stimulated peripheral blood mononuclear cells during chronic graft-versus-host disease. Eur J Haematol 1996;57:111-3.
10. Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RMM. CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HTV-2 but only indirectly to the viral load. J Immunol 2002;169:3400-6.