Base variant of human pancreatic secretory trypsin inhibitor in healing of stress-induced gastric lesions in rats

Regulatory Peptides

Volumn 77, Issue 1-3, 1998, Pages 95-103

  Konturek, Peter Ch ^a   Brzozowski, Tomasz ^b   Konturek, Stanislaw J ^b   Taut, Astrid ^a   Pierzchalski, Piotr ^b   Elia, George ^c   Pajdo, Robert ^b   Yagi, Shigeo ^d   Hahn, Eckhart G ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d SHIONOGI AND CO LTD   (Japan)

Author keywords

Gastric acid; Gastric blood flow; Gastroprotection; Immunocytochemistry; PSTI; RT PCR; Stress; Ulcer healing

Indexed keywords

APROTININ; ARGININE; ENZYME INHIBITOR; MESSENGER RNA; PANCREAS ENZYME; PEPSIN A; RECOMBINANT PROTEIN; SERINE; SERINE PROTEINASE; STOMACH SECRETION INHIBITOR; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; HALF LIFE TIME; IMMUNOHISTOCHEMISTRY; NONHUMAN; PEPSIN SECRETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; SOUTHERN BLOTTING; STOMACH ACID SECRETION; STOMACH BLOOD FLOW; STOMACH LESION; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH SECRETION; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; ULCER HEALING;

ANIMALS; BLOTTING, SOUTHERN; GASTRIC MUCOSA; HUMANS; IMMERSION; IMMUNOHISTOCHEMISTRY; MALE; MUTAGENESIS, SITE-DIRECTED; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; RNA, MESSENGER; STOMACH DISEASES; STRESS; TRYPSIN; TRYPSIN INHIBITOR, KAZAL PANCREATIC;

FISTULA;

EID: 17744406132     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(98)00105-0     Document Type: Article

References (36)

1. [1] Soll AH. Gastric, duodenal and stress ulcers. In: Sleisenger MH, Fordtran JS, editors. Gastrointestinal Disease: Pathophysiology, Diagnosis and Management. Philadelphia: WB Saunders, 1993:580-679.
2. [2] Lacroix J, Infante-Rivard C, Jenicek M, Gauthier M. Prophylaxis of upper gastrointestinal bleeding in intensive care units: a metaanalysis. Crit Care Med 1989;17:862-9.
3. [3] Senay BC, Levine RJ. Synergism between cold and restraint for rapid production of stress ulcers in rats. Proc Soc Exp Biol 1967;124:1221-3.
4. [4] Konturek PC, Brzozowski T, Konturek SJ, Dembinski A. Role of epidermal growth factor, prostaglandin and sulfhydryls in stress induced gastric lesions. Gastroenterology 1990;99:1607-15.
5. [5] Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992;27:649-55.
6. [6] Konturek PC, Ernst H, Brzozowski T, Ihlm A, Konturek SJ, Hahn EG. Expression of epidermal growth factor and transforming growth factor alpha after exposure of rat gastric mucosa to stress. Scand J Gastroenterol 1996;31:209-16.
7. [7] Konturek PC, Brzozowski T, Konturek SJ, Elia G, Wright N, Sliwowski Z, Thin L, Hahn EG. Role of spasmolytic polypeptide in healing of stress-induced gastric lesions in rats. Regul Pept 1997;68:71-9.
8. [8] Schmassmann A, Stettler CH, Poulsom R, Tarasova N, Hirschi G, Flogerzi B, Matsumoto K, Nakamura T, Halter F. Role of HGF and its receptor c-met during gastric ulcer healing in rats. Gastroenterology 1997;113:1858-72.
9. [9] Playford RJ, Hanby AM, Quinn C, Calam J. Influence of inflammation and atrophy on pancreatic secretory trypsin inhibitor levels within the gastric mucosa. Gastroenterology 1994;106:735-41.
10. [10] Kazal LA, Spicer DS, Brahinsky RA. Isolation of a crystalline trypsin inhibitor-anticoagulant protein from the pancreas. J Am Chem Soc 1948;70:3034-40.
11. [11] Bohe M, Lindstrom CG, Ohlsson K. Varying occurrence of gastroduodenal immunoreactive pancreatic secretory trypsin inhibitor. J Clin Pathol 1987;40:1345-8.
12. [12] Fukayama M, Hayashi Y, Koike M, Ogawa M, Kosaki G. Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J Histochem Cytochem 1986;34:227-35.
13. [13] Ogawa M, Tomita N, Hori A, Matsuura N, Higashiyama M, Yamamoto T, Murata A, Mori T, Matsubara K. Pancreatic secretory trypsin inhibitor in cancers. Adv Exper Med Biol 1988;240:547-53.
14. [14] Playford RJ, Batten JJ, Freeman TC, Beardshall K, Vesey DA, Fenn GC, Baron JH, Calam J. Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol. Gut 1991;32:1396-400.
15. [15] Scheving LA. Primary amino acid sequence similarity between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor and members of the porcine secretin family. Arch Biochem Biophys 1983;226:411-3.
16. [16] Hunt LT, Barker WC, Dayhoff MO. Epidermal growth factor: internal duplication and probable relationship to pancreatic trypsin inhibitor. Biochem Biophys Res Commun 1974;60:1020-8.
17. [17] Fukuoka SI, Fushiki T, Kitagawa Y, Sugimoto EI. Competition of growth stimulating/cholecystokinin (CCK) releasing peptide with epidermal growth factor binding to 3T3 fibroblasts. Biochem Biophys Res Commun 1987;145:646-50.
18. [18] Chen YZ, Ikey S, Yamaguchi Y, Sameshima H, Sugita H, Moriyasu M, Ogawa M. The protective effects of long-acting recombinant human pancreatic secretory trypsin inhibitor (R44S-PSTI) in a rat model of cerulein-induced pancreatitis. Int Med Res 1996;24:59-68.
19. [19] Marchbank T, Chinery R, Hanby AM, Poulsom R, Elia G, Playford RJ. Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution. Am J Pathol 1996;148:715-22.
20. [20] Takagi KY, Kayuya Y, Watanabe K. Studies in the drugs for peptic ulcer: a reliable method for producing stress ulcers in rats. Chem Pharm Bull 1964;12:465-72.
21. 2 analog with local gastroprotective and ulcer healing activity. Eur J Pharmacol 1991;195:347-53.
22. [22] Tsuzuki S, Miura Y, Fushiki T, Oomoni T, Satoh T, Natori X, Sugimoto E. Molecular cloning and characterization of genes encoding rat pancreatic secretory trypsin inhibitor (PSTI) cDNA. Biochem Biophys Acta 1992;1132:199-202.
23. [23] Nudel U, Zakut R, Shani M, Neuman S, Levy Z, Vaffe D. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res 1983;11:1759-71.
24. [24] Tanoue K, Masayuki O, Tarnawski A, Wahistrom IV, Sugimachi K, Sarfeh IJ. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology 1996;110:549-57.
25. [25] Jankowski J, McMenemin R, Hopwood D, Penston J, Wormsley KG. Abnormal expression of growth regulatory peptides in Barret's mucosa. Clin Sci 1991;81:663-8.
26. [26] Konturek SJ. Role of growth factors in gastroduodenal protection and healing of peptic ulcers. Gastroenterol Clin N Am 1990;19:41-65.
27. [27] Konturek SJ, Brzozowski T, Konturek PC, Majka J, Dembinski A. Role of salivary glands and epidermal growth factor (EGF) in gastric secretion and mucosal integrity in rats exposed to stress. Regul Pept 1991;32:203-9.
28. [28] Brzozowski T, Konturek SJ, Majka J, Dembinski A, Drozdowicz D. Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats. Dig Dis Sci 1993;38:276-83.
29. [29] Slomiany BL, Slomiany A. Mucus and gastric mucosal protection. In: Domschke W, Konturek SJ, editors. The Stomach. Berlin: Springer Verlag, 1993:116-43.
30. [30] Allen A. Structure and function of gastrointestinal mucus. In: Johnson LR, editor. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1981:617-39.
31. [31] Svanes K, Ito S, Takeuchi K, Silen W. Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Gastroenterology 1982;82:1409-26.
32. [32] From D. Mechanisms involved in gastric mucosal resistance to injury. Ann Rev Med 1987;38:119-28.
33. [33] Tepperman BL, Soper BD. Effect of epidermal growth factor, transforming growth factor alpha and nerve growth factor on gastric mucosal integrity and microcirculation in rat. Regul Pept 1994;50:13-21.
34. [34] Brzozowski T, Konturek PC, Sliwowski Z, Drozdowicz D, Hahn EG, Konturek SJ. Importance of nitric oxide and capsaicin-afferent nerves in healing of stress lesions induced by epidermal growth factor. J Clin Gastroenterol 1997;25(Suppl 1):S28-38.
35. [35] Levy MJ, Seeling CB, Robinson NJ, Ranney JE. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci 1997;42(6):1255-9.
36. [36] Schiessel R, Feil W, Wenzl E. Mechanisms of stress ulcerations and implications for treatment. Gastroenterol Clin N Am 1990;19(1):101-18.