Digoxin-like and digitoxin-like immunoreactive substances in elderly people: Impact on therapeutic drug monitoring of digoxin and digitoxin concentrations

American Journal of Clinical Pathology

Volumn 115, Issue 4, 2001, Pages 600-604

  Wu, Sang Ling ^a   Li, Wei ^a   Wells, Alice ^a   Dasgupta, Amitava ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Digitoxin like immunoreactive substances; Digoxin; Digoxin like immunoreactive substances; DLIS; DTLIS; Elderly people

Indexed keywords

DIGITALIS LIKE FACTOR; DIGITOXIN; DIGOXIN;

AGED; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MONITORING; FLUORESCENCE POLARIZATION; HUMAN; LIVER DISEASE; MICROPARTICLE ENZYME IMMUNOASSAY; PRIORITY JOURNAL; UREMIA;

AGED; AGING; BLOOD VOLUME; DIGITOXIN; DIGOXIN; FEMALE; FLUORESCENCE POLARIZATION; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER DISEASES; MALE; MIDDLE AGED; UREMIA;

EID: 17744400276     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AMD4-X6QR-X5VR-5EM1     Document Type: Article

References (14)

1. Nanji AA, Greenway DC. Falsely raised plasma digoxin concentrations in liver disease. Br Med J (Clin Res Ed). 1985;290:432-433.
2. Soldin SJ. Digoxin issues and controversies. Clin Chem. 1986;32:5-12.
3. Graves SW, Brown B, Valdes R Jr. Digoxin-like immunoreactive substances in a patient with renal impairment. Ann Intern Med. 1983;99:604-608.
4. Sault MH, Vasdev SC, Longerich LL. Endogenous digoxin-like substances in patients with combined hepatic and renal failure. Ann Intern Med. 1984;58:748-751.
5. Cloix JF. Endogenous digitalis-like compounds. Hypertension. 1987;10(suppl I):67-70.
6. Shilo L, Adawi A, Solomon G, et al. Endogenous digoxin-like immunoreactivity in congestive heart failure. Br Med J (Clin Res Ed). 1987;295:415-416.
7. Valdes R Jr, Graves SW. Protein binding of endogenous digoxin-immunoactive factors in human serum and its variation with clinical condition. J Clin Endocrinol Metab. 1985;60:1135-1143.
8. Stone JA, Soldin SJ. An update on digoxin. Clin Chem. 1989;35:1326-1331.
9. Jortani S, Miller JJ, Helm RA, et al. Unexpected suppression of digoxin values caused by DLIS [abstract]. Clin Chem. 1996;42:S124.
10. Dasgupta A, Trejo O. Suppression of total digoxin concentrations by digoxin-like immunoreactive substances in the MEIA digoxin assay: elimination of interference by monitoring free digoxin concentrations. Am J Clin Pathol. 1999;111:406-410.
11. Luke M, Dasgupta A. Digitoxinlike and digoxinlike immunoreactivities in sera of patients with uremia and liver disease as measured by fluorescence polarization immunoassays: poor correlation between digitoxinlike and digoxinlike immunoreactivities. Ther Drug Monit. 1997;19:230-235.
12. Ebara H, Suzuki S, Nagashima K, et al. Digoxin and digitoxin-like immunoreactive substances in amniotic fluid, cord blood and serum of neonates. Pediatr Res. 1986;20:28-31.
13. Yamamoto T, Takano K, Sanaka M, et al. Digoxin-like immunoreactive substances in elderly patients and its impact on the TDx digoxin assay. Ther Drug Monit. 1998;20:417-421.
14. Lackner TE, Lau BW, Parvin C, et al. Endogenous digoxin-like immunoreactivity in elderly patients with normal serum creatinine concentrations. Clin Pharm. 1988;7:449-453.