N-acetyl-cysteine attenuates endotoxin-induced adhesion molecule expression in human whole blood

Anesthesia and Analgesia

Volumn 100, Issue 5, 2005, Pages 1453-1457

  Nandate, Koichiroh ^a   Ogata, Masanori ^a   Tamura, Hitomi ^a   Kawasaki, Takashi ^a   Sata, Takeyoshi ^a   Shigematsu, Akio ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CD11B ANTIGEN; CELL ADHESION MOLECULE; ENDOTOXIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; ATTENUATION; BLOOD; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; NORMAL HUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; UPREGULATION;

ACETYLCYSTEINE; ANTIGENS, CD11B; CELL ADHESION MOLECULES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; HUMANS; INTERLEUKIN-8; L-SELECTIN; LEUKOCYTES;

EID: 17744399749     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000148616.24996.E7     Document Type: Article

References (17)

1. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328:1471-7.
2. Bone RC. Inhibitors of complement and neutrophils: a critical evaluation of their role in the treatment of sepsis. Crit Care Med 1992;20:891-8.
3. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033-6.
4. Villa P, Ghezzi P. Effect of N-acetyl-L-cysteine on sepsis in mice. Eur J Pharmacol 1995;292:341-4.
5. Zhang H, Spapen H, Nguyen DN, et al. Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol 1994;266:H1746-54.
6. Spies CD, Reinhart K, Witt I, et al. Influence of N-acetyl-cysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit Care Med 1994;22:1738-46.
7. Weigand MA, Plachky J, Thies JC, et al. N-acetyl-cysteine attenuates the increase in alpha-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion in humans undergoing liver transplantation. Transplantation 2001;72:694-8.
8. Schmidt H, Schmidt W, Muller T, et al. N-acetyl-cysteine attenuates endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Crit Care Med 1997;25:858-63.
9. Detmers PA, Lo SK, Olsen-Egbert E, et al. Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J Exp Med 1990;171:1155-62.
10. Kharazmi A, Nielsen H, Schiotz PO. N-acetyl-cysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolism. Int J Immunopharmacol 1988;10:39-46.
11. Peristeris P, Clark BD, Gatti S, et al. N-acetyl-cysteine and glutathione as inhibitors of tumor necrosis factor production. Cell Immunol 1992;140:390-9.
12. Bakker J, Zhang H, Depierreux M, et al. Effects of N-acetyl-cysteine in endotoxic shock. J Crit Care 1994;9:236-43.
13. Norgauer J, Krutmann J, Dobos GJ, et al. Actin polymerization, calcium-transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide. J Invest Dermatol 1994;102:310-4.
14. Ley K, Bullard DC, Arbones ML, et al. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J Exp Med 1995;181:669-75.
15. Kishimoto TK, Jutila MA, Berg EL, Butcher EC. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 1989;245:1238-41.
16. Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development. Science 1998;282:1281-4.
17. Hafezi-Moghadam A, Thomas KL, Prorock AJ, et al. L-selectin shedding regulates leukocyte recruitment. J Exp Med 2001;193:863-72.