Lung epithelial ion transport in neonatal lung disease

Biology of the Neonate

Volumn 80, Issue SUPPL. 1, 2001, Pages 14-17

  Pitkänen, Olli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Epithelium; Ion transport; Lung liquid; Respiratory distress syndrome

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMILORIDE; CHLORIDE ION; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION;

BASOLATERAL MEMBRANE; CONFERENCE PAPER; CRITICAL ILLNESS; HUMAN; HUMAN CELL; HUMAN TISSUE; ION TRANSPORT; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; NEWBORN; NEWBORN DISEASE; PRIORITY JOURNAL; RESPIRATORY DISTRESS;

ANIMALS; BIOLOGICAL TRANSPORT; CHLORIDE CHANNELS; EPITHELIAL SODIUM CHANNEL; EPITHELIUM; HUMANS; INFANT, NEWBORN; ION CHANNELS; LUNG; LUNG DISEASES; MUTATION; NA(+)-K(+)-EXCHANGING ATPASE; SODIUM CHANNELS;

EID: 17744398829     PISSN: 00063126     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047171     Document Type: Conference Paper

References (24)

1. Pitkänen OM, O'Brodovich HM: Significance of ion transport during lung development and in respiratory disease of the newborn. Ann Med 1998;30:134-142.
2. Brown MJ, Olver RE, Ramsden CA, Strang LB, Walters DV: Effects of adrenaline and spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol 1983;344:137-152.
3. Moessinger AC, Harding R, Adamson TM, Singh M, Kiu GT: Role of lung fluid volume in growth and maturation of the fetal sheep lung. J Clin Invest 1990;86:1270-1277.
4. Egan EA, Olver RE, Strang LB: Changes in non-electrolyte permeability of alveoli and the absorption of lung liquid at the start of breathing in the lamb. J Physiol 1975;244:161-179.
5. Bland RD, Bressack MA, McMillan DD: Labour decreases the lung water content of newborn rabbits. Am J Obstet Gynecol 1979;135: 364-367.
6. Bland RD: Lung epithelial ion transport and fluid movement during perinatal period. Am J Physiol 1990;259:L30-L37.
7. Ingbar DH, Weeks CB, Gilmore-Hebert M, Jacobsen E, Duvick S, Dowin R, Savik SK, Jamieson JD: Developmental regulation of Na,K-ATPase in rat lung. Am J Physiol 1996; 270:L619-L629.
8. Yasui M, Serlachius E, Löfgren M, Belusa R, Nielsen S, Aperia A: Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung. J Physiol 1997;505: 3-11.
9. King LS, Nielsen S, Agre P: Aquaporin-1 water channel protein in lung: Ontogeny, steroid-induced expression, and distribution in rat. J Clin Invest 1996;97:2183-2191.
10. Pitkänen OM, Tanswell AK, Downey G, O'Brodovich H: Increased PO2 alters the bioelectric properties of fetal distal lung epithelium. Am J Physiol 1996;270:L1060-L1066.
11. O'Brodovich H, Hannam V, Seear M, Mullen JBM: Amiloride impairs lung water clearance in newborn guinea pigs. J Appl Physiol 1990; 68:1758-1762.
12. + channel in the developing rat lung. Am J Physiol 1993;265:C491-C496.
13. Hummler E, Barker P, Gatzy J, Beerman F, Verdumo C, Schmidt A, Boucher R, Rossier B: Early death due to detective neonatal lung liquid clearance in αENaC-deficient mice. Nat Genet 1996;12:325-328.
14. + channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldostcronism phenotype. Proc Natl Acad Sci 1999;96:1727-1731.
15. DeSa DJ: Pulmonary fluid content in infants with respiratory distress. J Pathol 1969;97: 469-479.
16. Jefferies AL, Coates G, O'Brodovich H: Pulmonary epithelial permeability in hyaline-membrane disease. N Engl J Med 1984;311: 1075-1080.
17. Barker PM, Boucher RC, Yankaskas JR: Bioelectric properties of cultured monolayers from epithelium of distal human fetal lung. Am J Physiol 1995;268:L270-L277.
18. Venkatesh VS, Katzberg HD: Glucocorticoid regulation of epithelial sodium channel genes in human fetal lung. Am J Physiol 1997;273: L227-L233.
19. + channel (ENaC) expression in the developing normal and abnormal human perinatal lung. Am J Respir Crit Care Med 2000;161:1322-1331.
20. Pitkänen OM, Smith D, O'Brodovich H, Otulakowski G: Expression of α, β, and γ-hENaC mRNA in the human nasal, bronchial and distal lung epithelium. Am J Respir Crit Care Med, in press.
21. Kerem E, Bistritzer T, Hanakoglu A, Hofman T, Zhou Z, Bennett W, MacLaughlin E, Barker P, Nash M, Quittell L, Boucher R, Knowles M: Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudohypoaldosteronism. N Engl J Med 1999;341:156-162.
22. Gowen CW, Lawson EE, Gingras J, Boucher RC, Gatzy JT, Knowlcs MR: Electrical potential difference and ion transport across nasal epithelium of term neonates: Correlation with mode of delivery, transient tachypnea of the newborn, and respiratory rate. J Pediatr 1988; 113:121-127.
23. Barker PM, Gowen CW, Lawson EE, Knowles MR: Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome. J Pediatr 1997;130:373-377.
24. Eisler G, Hjertberg R, Lagercrantz H: Randomised controlled trial of effect of terbutaline before elective cacsarcan section on postnatal respiration and glucose homeostasis. Arch Dis Child Fetal Neonatal Ed 1999;80:F88-F92.