Radon therapy for the treatment of rheumatic diseases - Review and meta-analysis of controlled clinical trials

Rheumatology International

Volumn 25, Issue 3, 2005, Pages 205-210

  Falkenbach, Albrecht ^a,b   Kovacs, J ^a   Franke, A ^c   Jorgens K ^d   Ammer, K ^e  

^a Gasteiner Heilstollen Hospital   (Austria)

^b Gastein Research Institute   (Austria)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d Rosentritt Klinik   (Germany)

^e L Boltzmann Res Inst Phys Diagn   (Austria)

Author keywords

Ankylosing spondylitis; Radon; Rheumatoid arthritis; Spa; Spinal disease

Indexed keywords

RADON;

ANKYLOSING SPONDYLITIS; ARTICLE; CLINICAL TRIAL; DATA BASE; DEGENERATIVE DISEASE; FOLLOW UP; HUMAN; LONG TERM CARE; MEDICAL INFORMATION; MEDLINE; META ANALYSIS; METHODOLOGY; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPINE DISEASE; STATISTICAL SIGNIFICANCE; BRACHYTHERAPY; CONTROLLED CLINICAL TRIAL; FEMALE; JOINT CHARACTERISTICS AND FUNCTIONS; MALE; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RANDOMIZED CONTROLLED TRIAL; REVIEW; RHEUMATIC DISEASE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

ARTHRITIS, RHEUMATOID; BRACHYTHERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; MALE; PAIN MEASUREMENT; RADIOTHERAPY DOSAGE; RADON; RANDOMIZED CONTROLLED TRIALS; RANGE OF MOTION, ARTICULAR; RHEUMATIC DISEASES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SPONDYLITIS, ANKYLOSING; TREATMENT OUTCOME;

EID: 17744398204     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-003-0419-8     Document Type: Article

References (45)

1. Deetjen P (1992) Radon-Balneotherapie - neue Aspekte. Phys Rehab Kur Med 2:100-103
2. Pershagen G, Akerblom G, Axelson O et al (1994) Residential radon exposure and lung cancer in Sweden. N Engl J Med 330:159-164
3. Steindorf K, Lubin J, Wichmann HE, Becher H (1995) Lung cancer deaths attributable to indoor radon exposure in West Germany. Int J Epidemiol 24:485-492
4. Bogoljubow VM, Davydowa OB, Andrejew (1990) Radon-Luftbäder in der UdSSR: Forschung und Einsatz. Z Phys Med Baln Med Klim 19 [Sonderheft 2]:90-98
5. Pratzel HG, Schnizer W (1992) Handbuch der medizinischen Bäder: Radon-Bäder. Haug, Heidelberg, pp 125-129
6. Yamaoka K, Komoto Y (1996) Experimental study of alleviation of hypertension, diabetes and pain by radon inhalation. Physiol Chem Phys Med NMR 28:1-5
7. Yonehara H, Ma J, Ikebuchi M, Aoyama T (1999) Changes in superoxide dismutase (SOD) activity in organs of rat induced by radon exposure. In: Inaba J, Yonehara H, Doi M (eds) Indoor radon exposure and its health consequences. Kodansha, Tokyo, pp 123-129
8. Yamaoka K, Mifune T, Mitsunobu F, Kojima S, Mori S, Shibuya K, Tanizaki Y, Sugita K (2001) Basic studies on radon effects and thermal effects on humans in radon therapy. Physiol Chem Phys Med NMR 33:133-138
9. Pfaller W (1979) Subzelluläre Veränderungen der Nebennierenrinde nach Inhalation von 222Rn. Z Angew Bäder- u Klimaheilk 26:384-390
10. Reinisch N, Mur E, Herold M, Dunzendorfer S, Kahler CM, Falkenbach A, Wiedermann CJ (1999) Decrease of respiratory burst in neutrophils of patients with ankylosing spondylitis by combined radon-hyperthermia treatment. Clin Exp Rheumatol 17:335-338
11. Pratzel HG, Legler B, Heisig S, Klein G (1999) Schmerzstillender Langzeiteffekt durch Radonbäder bei nicht entzündlichen rheumatischen Erkrankungen. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 163-182
12. Hofmann W, Lettner H, Winkler R, Foisner W (1999) Perkutaner Radon-Transfer und Strahlenexposition durch Radonzerfallsprodukte beim Radon-Thermalwasserbad. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 83-91
13. Falkenbach A, Just G, Soto J (2000) Radon progeny activity in sweat following radon exposure in a warm and humid environment. Radiat Environm Biophys 39:137-139
14. Falkenbach A, Kleinschmidt J, Soto J, Just G (2002) Radon progeny activity on skin and hair after speleotherapeutic radon exposure. J Environ Radioactivity 62:217-223
15. Jadad M, Moore M, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al (1996) Assessing the quality of reports of randomised clinical trials: is blinding necessary? Control Clin Trials 17:1-12
16. Pratzel HG, Legler B, Aurand K, Baumann K, Franke T (1993) Wirksamkeitsnachweis von Radonbädern im Rahmen einer kurortmedizinischen Behandlung des zervikalen Schmerzsyndroms. Phys Rehab Kur Med 3:76-82
17. Clarke M, Oxman AD (2000) Analysing and presenting results. Handbook 4.1, section 8, in the Review Manager (RevMan) computer program, version 4.1. Cochrane, Oxford
18. Lind-Albrecht G (1994) Einfluss der Radonstollentherapie auf Schmerzen und Verlauf bei Spondylitis ankylosans. Thesis, Johannes Gutenberg University, Mainz
19. Fischer AA (1986) Pressure threshold meter: its use for quantification of tender spots. Arch Phys Med Rehabil 67:836-838
20. Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (2000) Long-term efficacy of radon spa therapy in rheumatoid arthritis - a randomised, sham-controlled study and follow-up. Rheumatology (Oxford) 39:894-902
21. van Tubergen A, Landewé R, van der Heijde D, Hidding A, Wolter N, Asscher M, Falkenbach A, Genth E, Goei Thé H, van der Linden S (2001) Combined spa-exercise therapy is effective in ankylosing spondylitis patients: a randomised controlled trial. Arthritis Rheum 45:430-438
22. Zielke VA, Just L, Schubert M, Tautenhahn B (1973) Objective evaluation of complex balneotherapy based on the use of radon in ankylosing spondylitis and rheumatoid arthritis [German]. Z Physiother 25:113-117
23. Aryppaeva TT (1974) Dynamics of the activity of lysosomal enzymes and proteoglycan-like compounds in patients with primary deforming osteoarthrosis under the effect of radon baths with radon concentration: 100 (36.4 nKi/l) and 3000 (109.2 nKi/l) Mache units [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:509-512
24. Tsarfis PG, Kostrova VD, Gerasimenko VN, Fiveiskaia AA (1974) Effect of radon baths with radon concentration of 100 Mache units (36.4 nKi/l) on the patients with deforming osteoarthritis with myocardial lesion [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:506-509
25. Tsarfis PG, Gerasimenko VN, Fiveiskaia AA, Proskurova GI, Vetrova LP (1975) Use of radon baths of different concentrations in osteoarthritis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:241-219
26. Asalkhanov IUA (1976) Comparative effectiveness of the use of radon baths at concentrations of 40 and 200 nCi/l in the treatment of ankylosing spondylitis. Vopr Kurortol Fizioter Lech Fiz Kult:39-41
27. Fiveiskaia AA (1976) Effectiveness of treatment of rheumatoid arthritis with radon baths of different concentrations [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:35-39
28. Gerasimenko VN (1976) Treatment of osteoarthritis deformans with radon baths of high concentration [200 and 400 nCi/l]. Vopr Kurortol Fizioter Lech Fiz Kult:28-31
29. Pshetakovskii IL (1976) Mechanism of the action and the effectiveness of radon treatment of rheumatoid arthritis of varied activity [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:31-35
30. Tsarfis PG (1976) Therapeutic effect of radon baths of different concentrations in inflammatory and dystrophic diseases [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:1-7
31. Steiner FJF, Valkenburg HA, van de Stadt RJ, Stoyanova-Drenska M, Zant J (1979) Spa therapy in patients with rheumatoid arthritis [Dutch]. Ned T Geneesk 16:661-664
32. Tondii LD, Vasilieva-Linetskaia LIa, Shtern MR (1979) Effect of Ichthyol electrophoresis with sinusoidal modulated currents combined with radon baths on the clinical biochemical indices in osteoarthrosis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:53-56
33. Sorokina EI, Davydova OB, Shubina AV, Riazantsev KM (1981) High-frequency electromagnetic fields and radon baths in the treatment of rheumatism [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:56-60
34. Mikunis RI, Dubovoi AF, Adamenko DL, Boiko IA (1985) Use of dry-air radon baths at the sanatorium stage of rehabilitation of patients with rheumatoid arthritis. Vopr Kurortol Fizioter Lech Fiz Kult:61-63
35. Trigorieva VD, Lomsadze VS (1985) Use of natural, weak hydrogen sulfide waters artificially enriched with radon in patients with osteoarthrosis deformans [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:43-46
36. Tsarfis PG, Kopieva TN, Abdusliamova LI, Makarova OV (1987) Effect of radon baths and their combination with decimeter-wave therapy on the joint syndrome in rheumatoid arthritis. Vopr Kurortol Fizioter Lech Fiz Kult:25-29
37. Galliamov AG, Valeev RG (1990) Radon therapy and the use of acupuncture reflexotherapy in patients with cervical and lumbar osteochondrosis [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult:50
38. Shliapak EA, Gabidova NT, Evseeva SN, Apanasevich ZK, Shvedunova LN (1992) A low-frequency alternating magnetic field and its combination with radon baths in juvenile rheumatoid arthritis [Russian]. Vopr Kurortol Fizioter Lech Fiz Kult 4:13-17
39. Veinpalu EIU, Trink RF, Veinpalu LE, Pyder KhA (1992) The therapeutic action of low-water bulk of therapeutic sea mud. Vopr Kurortol Fizioter Lech Fiz Kult:54-57
40. Bernatzky G, Graf AH, Saria A, Hofmann W, Lettner H, Adam H, Leiner G (1994) Schmerzhemmende Wirkung einer Kurbehandking bei Patienten mit Spondylitis ankylopoetica. Österr Z Phys Med 4:85-94
41. Dicheva MA, Khyshiktuev BS, Anikina LV, Popov VM (1998) Changes in the mineral metabolic indices of osteoarthrosis patients with the use of radon therapy and mud therapy. Vopr Kurortol Fizioter Lech Fiz Kult:37-38
42. Falkenbach A, Wolter NJGB, Herold M (1999) Klinische Studien zur Wirksamkeit der Radonthermalstollen-Behandlung bei Morbus Bechterew. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 111-129
43. 2. In: Deetjen P, Falkenbach A (eds) Radon und Gesundheit. Lang, Frankfurt, pp 103-109
44. Hunt DL, McKibbon K (1997) Locating and appraising systematic reviews. Ann Intern Med 126:532-538
45. Meade MO, Richardson WS (1997) Selecting and appraising studies for a systematic review. Ann Intern Med 127:531-537