Analysis of chimerism within specific leukocyte subsets for detection of residual or recurrent leukemia in pediatric patients after allogeneic stem cell transplantation

Leukemia

Volumn 15, Issue 2, 2001, Pages 307-310

  Lion, T ^a   Daxberger, H ^a   Dubovsky, J ^a   Filipcik, P ^a   Fritsch, G ^a   Printz, D ^a   Peters, C ^a   Matthes Martin, S ^a   Lawitschka, A ^a   Gadner, H ^a  

^a CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CD14 ANTIGEN; CD15 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; DNA; ETOPOSIDE; FLUDARABINE; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE SURFACE MARKER; MICROSATELLITE DNA; MONOCLONAL ANTIBODY; OKT 3; PREDNISONE; T LYMPHOCYTE RECEPTOR; THIOTEPA; THYMOCYTE ANTIBODY; TUMOR MARKER;

ADOLESCENT; ALLOGRAFT; ARTICLE; CANCER DIAGNOSIS; CANCER RECURRENCE; CELL SELECTION; CHILD; CHILDHOOD LEUKEMIA; CHIMERA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; GENETIC ANALYSIS; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; LEUKEMIA; MALE; MINIMAL RESIDUAL DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; T LYMPHOCYTE SUBPOPULATION; TANDEM REPEAT; WHOLE BODY RADIATION;

EID: 17744390547     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402017     Document Type: Note

References (8)

1. Kinetics of chimerism during the early post-transplant period in pediatric patients with malignant and non-malignant hematologic disorders: Implications for timely detection of engraftment, graft failure and rejection
2. Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT
3. Flow cytometric monitoring of hematopoietic reconstitution in myeloablated patients following allogeneic transplantation
4. Detection of recipient cells after non-T cell depleted bone marrow transplantation for leukemia by PCR amplification of minisatellites or of a Y chromosome marker has different prognostic value
5. Highly sensitive polymerase chain reaction methods show the frequent survival of residual recipient multipotent progenitors after non-T cell-depleted bone marrow transplantation
6. Persistence of host-type hematopoiesis after allogeneic bone marrow transplantation for leukemia is significantly related to the recipient's age and/or the conditioning regimen, but it is not associated with an relapse
7. Prevention of relapse in pediatric patients with acute leukemias and MDS after allogeneic SCT by early immunotherapy initiated on the basis of increasing mixed chimerism: A single center study of 12 children
8. Chimerism testing after allogeneic stem cell transplantation: Importance of timing and optimal technique for chimerism testing in different clinical-biological situations