FDG uptake, GLUT-1 glucose transporter and cellularity in human pancreatic tumors

Journal of Nuclear Medicine

Volumn 39, Issue 10, 1998, Pages 1727-1735

  Higashi, Tatsuya ^a   Tamaki, Nagara ^b   Torizuka, Tatsuo ^b   Nakamoto, Yuji ^b   Sakahara, Harumi ^b   Kimura, Toshiyuki ^b   Honda, Toyohiko ^b   Inokuma, Tetsuro ^b   Katsushima, Shinji ^b   Ohshio, Gakuji ^b   Imamura, Masayuki ^b   Konishi, Junji ^b  

^a KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b NONE

Author keywords

Cellularity; Fluorodeoxyglucose PET; GLUT 1 expression; Immunohistochemistry; Pancreatic tumor

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; FEMALE; GLUCOSE UTILIZATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; PANCREAS TUMOR; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ADENOCARCINOMA; FEMALE; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; PANCREAS; PANCREATIC NEOPLASMS; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 17644447468     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bares R, Klever P, Hauptmann S, et al. F-18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer. Radiology 1994;192:79-86.
2. Hawkins RA, Hoh C, Dahlbom M, et al. PET cancer evaluations with FDG [Editorial]. J Nucl Med 1991;32:1555-1558.
3. Ishizu K, Sadato N, Yonekura Y, et al. Enhanced detection of brain tumors by [18F]fluorodeoxyglucose PET with glucose loading. J Comput Assit Tomogr 1994; 18:12-15.
4. Kern KA, Brunetti A, Norton JA, et al. Metabolic imaging of human extremity musculoskeletal tumors by PET. J Nucl Med 1988;29:181-186.
5. Kubota K, Matsuzawa T, Fujiwara T, et al. Differential diagnosis of lung tumor with positron emission tomography: a prospective study. J Nucl Med 1990;31:1927-1932.
6. Strauss LG, Clorius JH, Schlag P, et al. Recurrence of colorectal tumors: PET evaluation. Radiology 1989;170:329-332.
7. Torizuka T, Tamaki N, Inokuma T, et al. Value of fluorine-18-FDG-PET to monitor hepatocellular carcinoma after interventional therapy. J Nucl Med 1994;35:1965-1969.
8. Wahl RL, Cody RL, Hutchins GD, Mudgett EE. Primary and metastatic breast carcinoma: initial clinical evaluation with PET with the radiolabeled glucose analogue 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 1991;179:765-770.
9. Inokuma T, Tamaki N, Torizuka T, et al. Evaluation of pancreatic tumors with positron emission tomography and F-18 fluorodeoxyglueose: comparison with CT and US. Radiology 1995;195:345-352.
10. Inokuma T, Tamaki N, Torizuka T, et al. Value of fluorine-18-fluorodeoxyglucose and thallium-201 in the detection of pancreatic cancer. J Nucl Med 1995;36:229-235.
11. Yonekura Y, Benua RS, Brill AB, et al. Increased accumulation of 2-deoxy-2-[18F]fluoro-D-glucose in liver metastases from colon carcinoma. J Nucl Med 1982; 23:1133-1137.
12. Warburg O. The metabolism of tumors. Constable 1930:254-270.
13. Higashi T, Tamaki N, Honda T, et al. Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study. J Nucl Med 1997;38:1337-1344.
14. Higashi K, Clavo AC, Wahl RL. Does FDG uptake measure proliferative activity of human cancer cells? In vitro comparison with DNA flow cytometry and tritiated thymidine uptake J Nucl Med 1993;34:414-419.
15. Torizuka T, Tamaki N, Inokuma T, et al. In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET. J Nucl Med 1995;36:1811-1817.
16. Wahl RL. Targeting glucose transporters for tumor imaging: "sweet" idea, "sour" results. J Nucl Med 1996;37:1038-1041.
17. Brown RS, Leung JY, Fisher SJ, Frey KA, Ethier SP, Wahl RL. Are inflammatory cells important? J Nucl Med 1995;36:1854-1861.
18. Kubota K, Yamada S, Kubota K, et al. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 1992;33:1972-1980.
19. Ito K, Kato T, Ohta M, et al. Diagnostic usefulness and limitation of FDG-PET in recurrent rectal cancer. In: Matsuzawa T, ed. Proceedings of the second international symposium of clinical PET in oncology. Singapore: World Scientific; 1994:199-206.
20. Kato T, Fukatsu H, Ito K, et al. Fluorodeoxyglucose positron emission tomography in pancreatic cancer: unsolved problem. Eur J Nucl Med 1995;22:32-39.
21. Tamaki N, Yonekura Y, Yamashita K, et al. Relation of left ventricular perfusion and wall motion with metabolic activity in persistent defects on thallium-201 tomography healed myocardial infarction. Am J Cardiol 1988;62:202-208.
22. Woodard HQ, Bigler RE, Freed B. Expression of tissue isotope distribution [Letter]. J Nucl Med 1975;16:958-959.
23. Wang LD, Shi ST, Zhou Q, et al. Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis. Int J Cancer 1994;59:514-519.
24. Cooley WW, Lohnes PR. Multivariate data analysis. New York: John Wiley and Sons; 1971.
25. Wang ZH, Manabe T, Ohshio G, et al. Immunohistochemical study of heparan sulfate proteoglycan in adenocarcinomas of the pancreas. Pancreas 1994;9:758-763.
26. Ohshio G, Yoshioka H, Manabe T, et al. Expression of sialosyl-Tn antigen (monoclonal antibody MLS102 reactive) in normal tissues and malignant tumors of the digestive tract. J Cancer Res Clin Oncol 1994;120:325-330.
27. Okazumi S, Enomoto K, Fukunaga T, et al. Evaluation of pancreatic lesions using 18F-fluorodeoxyglucose PET. J Japan Pancreas Society 1994;9:155-160.
28. Porter MR and Frantz VK. Tumors associaled with hypoglycemia: pancreatic and extrapancreatic. Am J Med 1956;21:944.
29. Merrall NW, Plevin R, Gould GW. Growth factors, mitogens, oncogenes and the regulation of glucose transport. Cell Signal 1993;5:667-675.
30. Birnbaum MJ, Haspel HC, Rosen OM. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 1987;235:1495-1498.
31. Dermietzel R, Krause D, Kremer M, Wang C, Stevenson B. Pattern of glucose transporter (Glut 1) expression in embryonic brains is related to maturation of blood-brain barrier tightness. Dev Dyn 1992;193:152-163.
32. Hermanek P, Sobin LH. TNM classification of malignant tumors, 4th ed. New York: Springer-Verlag; 1987.