Pregnancy-associated changes in peripheral blood lymphocyte subpopulations and serum cytokine concentrations in healthy women

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 50, Issue 4, 2005, Pages 246-250

  Kumru, Selahattin ^a   Boztosun, Abdullah ^a   Godekmerdan, Ahmet ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Cytokines; Lymphocytes; Pregnancy; Turkey

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GESTATION PERIOD; HUMAN; INTERMETHOD COMPARISON; MENSTRUAL CYCLE; NATURAL KILLER CELL; PERIPHERAL LYMPHOCYTE; PREGNANCY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SAMPLE SIZE; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE SUBPOPULATION;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; PREGNANCY; T-LYMPHOCYTE SUBSETS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 17644427657     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Wegman TG, Lin H, Guilbert L, et al: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomenon? Immunol Today 1993;147:353-356
2. Raghupathy R: Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997;18:476-482
3. Mellor AL, Munn DH: Immunology at the maternal-fetal interface: Lessons for T cell tolerance and suppression. Ann Rev Immunol 2000;18:367-391
4. Booney EA, Matzinger P: The maternal immune system's interaction with circulating fetal cells. J Immunol 1997;158:40-47
5. Inverrnizzi P, Battezzati PM, Podda M, et al: Presence of fetal DNA in maternal plasma decades after pregnancy: Further comments. Hum Genet 2002;6:576
6. Watanabe M, Iwatani Y, Kaneda T, et al: Changes in T, B, and NK lymphocyte subsets during and after normal pregnancy. Am J Reprod Immunol 1997;5:368-377
7. Fiddes TM, O'Reilly DB, Cetrulo CL, et al: Phenotypic and functional evaluation of suppressor cells in normal pregnancy and in chronic aborters. Cell Immunol 1986;2:407-418
8. Kuhnert M, Strohmeier R, Stegmuller M, et al: Changes in lymphocyte subsets during normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1998;2:147-151
9. Piccinni MP, Beloni L, Livi C, et al: Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 1998;9:1020-1024
10. Makhseed M, Raghupathy R, Azizieh F, et al: Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure. Am J Reprod Immunol 1999;5:273-281
11. Jenkins C, Roberts J, Wilson R, et al: Evidence of a T(H) 1 type response associated with recurrent miscarriage. Fertil Steril 2000;6:1206-1208
12. Makhseed M, Raghupathy R, Azizieh F, et al: Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod 2000;9:2011-2017
13. Caniggia I, Grisaru-Gravnosky S, Kuliszewsky M, et al: Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. J Clin Invest 1999;12:1641-1650
14. Simpson H, Robson SC, Bulmer JN, et al: Transforming growth factor beta expression in human placenta and placental bed during early pregnancy. Placenta 2002;1:44-58
15. Ho HN, Hultin E, Mitsuyasu RT, et al: Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993;150:3070-3079
16. Arck P, Blois S, Joachim R, et al: Pregnancy-protective effect of progesterone substitution with dydrogesterone in mice is dependent on CD8+ cells and mediated by a Th2>Th1 cytokine profile. Gynecol Endocrinol (suppl 1) 2004;18:136
17. Szekeres-Bartho J, Wegmann TG: A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol 1996;1-2:81-95
18. Coulam CB, Stephenson M, Stern JJ, et al: Immunotherapy for recurrent pregnancy loss: Analysis of results from clinical trials. Am J Reprod Immunol 1996;4:352-359
19. Yui J, Garcia-Lloret M, Wegmann TG, et al: Cytotoxicity of tumor necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta 1994;8:819-835
20. Makhseed M, Raghupathy R, Azizieh F, et al: Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001;10:2219-2226
21. Saito S: Cytokine cross-talk between mother and the embryo/placenta. J Reprod Immunol 2001;55:15-33
22. Miyaura H, Iwata M: Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J Immunol 2002;3:1087-1094
23. D'Elios M, Del Prete G: Th1/Th2 balance in human disease. Transplant Proc 1998;5:2373-2377
24. Ostenson M: Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann N Y Acad Sci 1999;876:131-134
25. Abbas AK, Lichtman AH, Hober JS: Cytokines. In Cellular and Molecular Immunology. Fourth edition, Philadelphia, WB Saunders, 2000, pp 235-269
26. Morrish DW, Bhardwaj D, Paras MT: Transforming growth factor betal inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology 1991;129:22-26
27. Chen XL, Gao HJ, Wei P, et al: Regulatory effect of IFN-gamma on expression of TGF-beta 1, T beta R-II, and StAR in corpus luteum of pregnant rhesus monkey. Acta Pharmacol Sin 2003;5:435-441
28. Taylor MJ, Clark CL. Transforming growth factor-beta is a potent inhibitor of basal and stimulated relaxin release by porcine luteal cells maintained in monolayer culture. J Endocrinol 1992;135:543-550
29. Power LL, Popplewell EJ, Holloway JA, et al: Immunoregulatory molecules during pregnancy and at birth. J Reprod Immunol 2002;56:19-28
30. Fornari MC, Sarto A, Berardi VE, et al: Effect of ovaric hyperstimulation on blood lymphocyte subpopulations, cytokines, leptin and nitrite among patients with unexplained infertility. Am J Reprod Immunol 2002;6:394-403