Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women

Journal of Bone and Mineral Research

Volumn 20, Issue 5, 2005, Pages 741-747

  Antoniucci, Diana M ^a,g   Sellmeyer, Deborah E ^a   Cauley, Jane A ^b   Ensrud, Kristine E ^c   Schneider, Jennifer L ^d   Vesco, Kimberly K ^e   Cummings, Steven R ^d   Melton III, L Joseph ^f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^e PORTLAND VA MEDICAL CENTER   (United States)

^f Mayo Clinic   (United States)

^g Mayo Clinic College of Medicine ^*  (United States)

Author keywords

Epidemiology; Hip fracture; Oophorectomy; Sex steroids; Vertebral fracture

Indexed keywords

ESTRADIOL; ESTROGEN; SEX HORMONE; TESTOSTERONE;

ADULT; AGED; ANDROGEN SYNTHESIS; ARTICLE; ESTRADIOL BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; FRACTURE; HIP FRACTURE; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MENOPAUSE; OSTEOPOROSIS; OVARIECTOMY; POSTMENOPAUSE; PROSPECTIVE STUDY; RISK ASSESSMENT; VERTEBRA FRACTURE;

AGED; BODY WEIGHT; BONE DENSITY; COHORT STUDIES; ESTRADIOL; FEMALE; FOLLOW-UP STUDIES; FRACTURES, BONE; HUMANS; MULTIVARIATE ANALYSIS; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; POSTMENOPAUSE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK; RISK FACTORS; TESTOSTERONE; TIME FACTORS;

EID: 17644419265     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.041220     Document Type: Article

References (25)

1. Albright F, Smith PH, Richardson AM 1941 Postmenopausal osteoporosis. JAMA 116:2465-2474.
2. Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC 1976 Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment. Lancet 1:1038-1041.
3. Riggs BL, Khosla S, Melton LJ III 2002 Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279-302.
4. Cummings SR. Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B 1998 Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med 339:733-738.
5. Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC 1996 Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women. J Clin Invest 97:14-21.
6. Hughes CL Jr, Wall LL, Creasman WT 1991 Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. Gynecol Oncol 40:42-45.
7. Judd HL, Lucas WE, Yen SS 1974 Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol 118:793-798.
8. Laughlin GA, Barrett-Connor E, Kritz-Silverstein D, von Muhlen D 2000 Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: The Rancho Bernardo Study. J Clin Endocrinol Metab 85:645-651.
9. Sluijmer AV, Heineman MJ, De Jong FH, Evers JL 1995 Endocrine activity of the postmenopausal ovary: The effects of pituitary down-regulation and oophorectomy. J Clin Endocrinol Metab 80:2163-2167.
10. Vermeulen A 1976 The hormonal activity of the postmenopausal ovary. J Clin Endocrinol Metab 42:247-253.
11. Couzinet B, Meduri G, Lecce MG, Young J, Brailly S, Loosfelt H, Milgrom E, Schaison G 2001 The postmenopausal ovary is not a major androgen-producing gland. J Clin Endocrinol Metab 86:5060-5066.
12. Carlson KJ, Nichols DH, Schiff I 1993 Indications for hysterectomy. N Engl J Med 328:856-860.
13. Melton LJ III, Khosla S, Malkasian GD, Achenbach SJ, Oberg AL, Riggs BL 2003 Fracture risk after bilateral oophorectomy in elderly women. J Bone Miner Res 18:900-905.
14. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE. Cauley J, Black D, Vogt TM 1995 Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332:767-773.
15. Cauley JA, LaPorte RE, Sandier RB, Schramm MM, Kriska AM 1987 Comparison of methods to measure physical activity in postmenopausal women. Am J Clin Nutr 45:14-22.
16. Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK 1992 Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 7:625-632.
17. Ensrud KE, Palermo L, Black DM, Cauley J, Jergas M, Orwoll ES, Nevitt MC, Fox KM, Cummings SR 1995 Hip and calcaneal bone loss increase with advancing age: Longitudinal results from the study of osteoporotic fractures. J Bone Miner Res 10:1778-1787.
18. Black DM, Palermo L, Nevitt MC, Genant HK, Christensen L, Cummings SR 1999 Defining incident vertebral deformity: A prospective comparison of several approaches. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 14:90-101.
19. Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, Nevitt MC, Genant HK, Cummings SR 2001 Structural adaptation to changing skeletal load in the progression toward hip fragility: The study of osteoporotic fractures. J Bone Miner Res 16:1108-1119.
20. Keshavarz H, Hillis SD, Kieke BA, Marchbanks PA 2002 Hysterectomy Surveillance-United States, 1994-1999 Surveillance Summaries. MMWR, Atlanta, GA, USA.
21. NIH Consensus Development Panel 2001 Osteoporosis prevention, diagnosis, and therapy. JAMA 285:785-795.
22. Ries LAG, Eisner MP. Kosary CL, Hankey BF, Miller BA, Clegg L, Mariotto A, Fay MP, Feuer EJ, Edwards BK 2003 SEER Cancer Statistics Review, 1975-2000. National Cancer Institute, Bethesda, MD, USA.
23. Bowman M 1997 Is screening and/or prophylactic oophorectomy for ovarian cancer of value in high risk women? Hum Reprod 12:203-204.
24. Huisman WM 1997 Prophylactic oophorectomy on postmenopausal women. Hum Reprod 12:204-205.
25. Gotlieb WH, Baruch GB, Friedman E 2000 Prophylactic oophorectomy: Clinical considerations. Semin Surg Oncol 19:20-27.