Lack of evidence for local immune activity in oral hairy leukoplakia and oral wart lesions

Oral Microbiology and Immunology

Volumn 20, Issue 3, 2005, Pages 154-162

  Lilly, E A ^a   Cameron, J E ^a   Shetty, K V ^a   Leigh, J E ^a   Hager, S ^a   McNulty, K M ^a   Cheeks, C ^a   Hagensee, M E ^a   Fidel Jr , Paul L ^a,b  

^a LOUISIANA STATE UNIV HLTH SCI C   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF DENTISTRY   (United States)

Author keywords

Cytokines; HIV; Oral hairy leukoplakia; Oral warts; T cells

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEUKOPLAKIA; MAJOR CLINICAL STUDY; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; VERRUCA VULGARIS; VIRUS LOAD; WART VIRUS;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD8; CHEMOKINES; CYTOKINES; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA, HAIRY; PAPILLOMAVIRIDAE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; WARTS;

EID: 17644416443     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2005.00198.x     Document Type: Article

References (26)

1. Ammatuna P, Campisi G, Giovannelli L, Giambelluca D, Alaimo C, Mancuso S, et al. Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients. Oral Dis 2001: 7: 34-40.
2. Ammatuna P, Capone F, Gaimbelluca D, et al. Detection of Epstein-Barr virus (EBV) DNA and antigens in oral mucosa of renal transplant patients without clinical evidence of oral hairy leukoplakia (OHL). J Oral Pathol Med 1998: 27: 420-427.
3. + T cell responses after natural primary infection of humans with Epstein-Barr virus. Viral Immunol 2003: 16: 3-16.
4. Cameron JE, Mercante DE, O'Brien M, Gaffga AM, Leigh JE, Fidel P Jr, et al. The impact of highly active antiretroviral therapy (HAART) immunodeficiency human papillomavirus (HPV) on infection in the oral cavity of HIV seropositive adults, (in press).
5. Campo J, Del Romero J, Castilla J, Garcia S, Rodriguez C, Bascones A. Oral candidiasis as a clinical marker related to viral load, CD4 lymphocyte count and CD4 lymphocyte percentage in HIV-infected patients. J Oral Pathol Med 2002: 31: 5-10.
6. de Jong A, Palefsky J, Stites D, Nakagawa M. Human immunodeficiency virus-positive individuals with oral hairy leukoplakia are able to mount cytotoxic T lymphocyte responses to Epstein-Barr virus. Oral Dis 2000: 6: 40-47.
7. Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlee F, Hildesheim A, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol 2000: 38: 357-361.
8. Greenspan D, Canchola AJ, MacPhail LM, Cheikh B, Greenspan JS. Effect of highly active antiretroviral therapy on frequency of oral warts. Lancet 2001: 357: 1411-1412.
9. Greenspan D, Greenspan JS. Oral 'hairy' leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet 1984: ii: 831-834.
10. Greenspan D, Greenspan JS, Hearst NG, Pan LZ, Conant MA, Abrams DI, et al. Relation of oral hairy leukoplakia to infection with the human immunodeficiency virus and the risk of developing AIDS. J Infect Dis 1987: 155: 475-481.
11. Greenspan D, Komaroff E, Redford M, Phelan JA, Navazesh M, Alves ME, et al. Oral mucosal lesions and HIV viral load in the Women's Interagency HIV Study (WIHS). J Acquir Immune Defic Syndr 2000: 25: 44-50.
12. Greenspan JS, Barr CE, Sciubba JJ, Winkler JR. Oral manifestations of HIV infection: definitions, diagnostic criteria and principles of therapy. Oral Surg Oral Med Oral Pathol 1992: 73: 142-144.
13. Greenspan JS, Greenspan D, Lennette E, et al. Replication of Epstein-Barr virus within the epithelial cells of oral 'hairy' leukoplakia, an AIDS-associated lesion. N Engl J Med 1985: 313: 1564-1571.
14. Itin P, Lautenschlager S. Viral lesions of the mouth in HIV-infected patients. Dermatology 1997: 194: 1-7.
15. Johnson G, Nelson S, Petric M, Tellier R. Comprehensive PCR-based assay for detection and species identification of human herpesviruses. J Clin Microbiol 2000: 38: 3274-3279.
16. King MD, Reznik DA, O'Daniels CM, Larsen NM, Osterholt D, Blumberg HM. Human papillomavirus-associated oral warts among human immunodeficiency virus-seropositive patients in the era of highly active antiretroviral therapy: an emerging infection. Clin Infect Dis 2002: 34: 641-648.
17. Leigh JE. Oral warts rise dramatically with use of new agents in HIV. HIV Clin 2000: 1: 7-8.
18. Leigh JE, Steele C, Wormley FL JrLuo W, Clark RA, Gallaher WR, et al. Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: a pilot study in HIV-positive individuals with oropharyngeal candidiasis. J Acquir Immune Deficiency Syndr Hum Retrovirol 1998: 19: 373-380.
19. Lilly E, Hart DJ, Leigh JE, Hager S, McNulty KM, Mercante DE, et al. Tissue-associated cytokine expression in HIV-positive persons with oropharyngeal candidiasis. J Infect Dis 2004: 190: 604-612.
20. Luxton J, Shepherd P. Human papillomavirus antigens and T-cell recognition. Curr Opin Infect Dis 2001: 14: 139-143.
21. Mota F, Rayment N, Chong S, Singer A, Chain B. The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium. Clin Exp Immunol 1999: 116: 33-40.
22. Myers TA, Leigh JE, Arribas A, Hager S, Clark RA, Lilly E, et al. Immunohistochemical evaluation of T cells in oral lesions from human immunodeficiency virus-positive persons with oropharyngeal candidiasis. Infect Immun 2003: 71: 956-963.
23. Rickinson AB, Moss DJ. Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection. Annu Rev Immunol 1997: 15: 405-431.
24. Scully C, Porter S, Di Alberti L, Jalal M, Maitland N. Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia and in healthy non-infected people. J Oral Pathol Med 1998: 27: 480-482.
25. Walling DM, Flaitz CM, Hosein FG, Montes-Walters M, Nichols CM. Effect of Epstein-Barr virus replication on Langerhans cells in pathogenesis of oral hairy leukoplakia. J Infect Dis 2004: 2004: 1656-1663.
26. Zehnder M, Greenspan JS, Greenspan D, Bickel M. Chemokine gene expression in human oral mucosa. Eur J Oral Sci 1999: 107: 231-235.