Treatment of segmental bone defects in rats by the stimulation of bone marrow osteo-progenitor cells with prostaglandin E2

International Orthopaedics

Volumn 29, Issue 2, 2005, Pages 73-77

  Ozturk, A M ^a,c   Cila, E ^a   Kanatli, U ^a   Isik, I ^a   Senkoylu, A ^a   Uzunok, D ^b   Piskin, E ^b  

^a GAZI UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMER; DRUG CARRIER; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEMINERALIZATION; BONE MATRIX; BONE MATURATION; CELL STIMULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FRACTURE HEALING; HEMATOPOIETIC STEM CELL; HISTOLOGY; INTERMETHOD COMPARISON; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOLOGY; RADIUS; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; BONE MARROW CELLS; BONE REGENERATION; BONE TRANSPLANTATION; DINOPROSTONE; FRACTURE HEALING; GROWTH SUBSTANCES; MALE; MODELS, ANIMAL; RADIUS FRACTURES; RATS; RATS, WISTAR; STEM CELLS; TISSUE ENGINEERING;

EID: 17644411062     PISSN: 03412695     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00264-004-0623-5     Document Type: Article

References (25)

1. Bauer TW, Muschler GF (2000) Bone graft materials. An overview of the basic science. Clin Orthop 371:10-27
2. Bingel SA (1999) Euthanasia and necropsy. In: An YH, Friedman RJ (eds) Animal models in orthopaedic research. CRC Press, Boca Raton, pp 71-81
3. Burchardt H (1987) Biology of bone transplantation. Orthop Clin North Am 18:187-196
4. Burwell RG (1964) Studies in the transplantation of bone. VII. The fresh composite homograft-autograft of cancellous bone an analysis of factors leading to osteogenesis in marrow-containing bone grafts. J Bone Joint Surg 46(B):110-140
5. Connolly JF, Guse R, Tiedeman J, Dehne R (1991) Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop 266:259-270
6. Cook SD, Baffes GC, Wolfe MW, Sampath TK, Rueger DC (1994) Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model. Clin Orthop 301:302-312
7. Ekholm M, Hietanen J, Lindqvist C, Rautavuori J, Santavirta S, Suuronen R (1999) Histological study of tissue reactions to epsilon-caprolactone-lactide copolymer in paste form. Biomaterials 20:1257-1262
8. Farso-Nielsen F, Karring T, Gogolewski S (1992) Biodegradable guide for bone regeneration. Polyurethane membranes tested in rabbit radius defects. Acta Orthop Scand 63:66-69
9. Flanagan AM, Chambers TJ (1992) Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2. Endocrinology 130:443-448
10. Fleming JE, Cornell CN, Muschler GF (2000) Bone cells and matrices in orthopedic tissue engineering. Orthop Clin North Am 31:357-374
11. Gepstein R, Weiss RE, Hallel T (1987) Bridging large defects in bone by demineralized bone matrix in the form of a powder. A radiographic, histological, and radioisotope-uptake study in rats. J Bone Joint Surg 69(A):984-992
12. Goshima J, Goldberg VM, Caplan AI (1991) The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop 262:298-311
13. Gruber HE, Stasky AA (1999) Histologic study in orthopaedic animal research. In: An YH, Friedman RJ (eds) Animal models in orthopaedic research. CRC Press, Boca Raton, pp 115-137
14. Kokubu T, Matsui N, Fujioka H, Tsunoda M, Mizuno K (1999) Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts. Biochem Biophys Res Commun 256:284-287
15. Lane JM, Sandhu HS (1987) Current approaches to experimental bone grafting. Orthop Clin North Am 18:213-225
16. Lindholm TS, Nilsson OS, Lindholm TC (1982) Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells. Clin Orthop 171:251-255
17. Nagata T, Kaho K, Nishikawa S, Shinohara H, Wakano Y, Ishida H (1994) Effect of prostaglandin E2 on mineralization of bone nodules formed by fetal rat calvarial cells. Calcif Tissue Int 55:451-457
18. Narumiya S, Sugimoto Y, Ushikubi F (1999) Prostanoid receptors: structures, properties, and functions. Physiol Rev 79:1193-1226
19. Nunamaker DM (1998) Experimental models of fracture repair. Clin Orthop 355 (Suppl):S56-S65
20. Nyman R, Magnusson M, Sennerby L, Nyman S, Lundgren D (1995) Membrane-guided bone regeneration. Segmental radius defects studied in the rabbit. Acta Orthop Scand 66:169-173
21. Solheim E, Pinholt EM, Andersen R, Bang G, Sudmann E (1992) The effect of a composite of polyorthoester and demineralized bone on the healing of large segmental defects of the radius in rats. J Bone Joint Surg Am 74:1456-1463
22. Tiedeman JJ, Connolly JF, Strates BS, Lippiello L (1991) Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop 268:294-302
23. Ural E, Kesenci K, Fambri L, Migliaresi C, Piskin E (2000) Poly(D,L-lactide/epsilon-caprolactone)/hydroxyapatite composites. Biomaterials 21:2147-2154
24. Weinreb M, Grosskopf A, Shir N (1999) The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype. Am J Physiol 276:E376-E383
25. Wixson SK, Smiler KL (1998) Anesthesia and analgesia in rodents. In: Kohn DF, Wixson SK, White WJ, Benson GJ (eds) Anesthesia and analgesia in laboratory animals. Academic, San Diego, pp 173-184