Effect of the mycotoxin, ochratoxin A, on hormone-stimulated ion transport in a cultured cell model of the renal principal cell

Pflugers Archiv European Journal of Physiology

Volumn 450, Issue 1, 2005, Pages 53-60

  Blazer Yost, Bonnie L ^a   West, T Aaron ^a   Stack, Jamie ^a   Peck, Kerrie ^a   Lahr, Thomas F ^a   Gekle, Michael ^b  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aldosterone; Anti diuretic hormone; Electrolyte homeostasis; ENaC; Epithelial sodium channel; IGF1; Insulin like growth factor 1; MDCK C7

Indexed keywords

ALDOSTERONE; MYCOTOXIN; OCHRATOXIN; SODIUM CHANNEL; SOMATOMEDIN C; VASOPRESSIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHRONIC TOXICITY; CONTROLLED STUDY; KIDNEY TUBULE ABSORPTION; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; SODIUM ABSORPTION; SODIUM TRANSPORT;

ANIMALS; CELL LINE; ION TRANSPORT; KIDNEY; OCHRATOXINS; SODIUM; TIME FACTORS;

EID: 17644402785     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-004-1374-2     Document Type: Article

References (23)

1. Benesic A, Mildenberger S, Gekle M (2000) Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney cells. Pflugers Arch 439:278-287
2. + transport in a high resistance clone of the MDCK cell line. Pflugers Arch 432:685-691
3. Egmond HP van, Speijers GJA (1994) Survey of data on the incidence and levels of ochratoxin A in food and animal feed worldwide. Nat Toxins 3:124-144
4. Gekle M, Silbernagl S (1996) Renal toxicodynamics of ochratoxin A: a pathophysiological approach. Kidney Blood Press Res 19:225-235
5. Gekle M, Oberleithner H, Silbernagl S (1993) Ochratoxin A impairs "postproximal" nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflugers Arch 425:401-408
6. Gekle M, Wunsch S, Oberleithner H, Silbernagl S (1994) Characterization of two MDCK-cell subtypes as a model system to study principal and intercalated cell properties. Pflugers Arch 428:157-162
7. Gekle M, Pollock CA, Silbernagl S (1995) Time- and concentration- dependent biphasic effect of ochratoxin A on growth of proximal tubular cells in primary culture. J Pharmacol Exp Ther 275:397-404
8. Gekle M, Gassner B, Freudinger R, Mildenberger S, Silbernagel S, Pfaller W, Schramek H (1998) Characterization of an ochratoxin-A-dedifferentiated and cloned renal epithelial cell line. Toxicol Appl Pharmacol 152:282-291
9. Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilfingseder D, Pollack V, Dander M, Schramek H (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 293:837-844
10. Gennari A, Pazos P, Boveri M, Callaghan R, Casado J, Maurici D, Corsini E, Prieto P (2004) New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin A. J Biochem Mol Toxicol 18:43-49
11. Grosso F, Said S, Mabrouk I, Fremy JM, Castegnaro M, Jemmali M, Dragacci S (2003) New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food Chem Toxicol 41:1133-1140
12. Kuiper-Goodman T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179-248
13. Lahr TF, Record RD, Hoover DK, Hughes CL, Blazer-Yost BL (2000) Characterization of the ion transport response to ADH in the MDCK-C7 cell line. Pflugers Arch 439:610-617
14. Maresca M, Mahfoud R, Pfohl-Leszkowicz A, Fantini J (2001) The mycotoxin ochratoxin A alters intestinal barrier and absorption functions but has no effect on chloride secretion. Toxicol Appl Pharmacol 176:54-63
15. Mullin JM (2004) Epithelial barriers, compartmentation and cancer. Sci STKE (216) pe2
16. Radic B, Fuch R, Peraica M, Lucic A (1997) Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicol Lett 91:105-109
17. Schaaf, GJ, Nijmeijer SM, Maas RFM, Roestenberg P, Groene EM de, Fink-Gremmels J (2002) The role of oxidative stress in the ochratoxin a-mediated toxicity in proximal tubular cells. Biochim Biophys Acta 1588:149-158
18. Schramek H, Wilflingseder D, Pollack V, Freundinger R, Mildenberger S, Gekle M (1997) Ochratoxin A-induced stimulation of extracellular signal-regulated kinases is associated with Madin-Darby canine kidney C7 cell dedifferentiation. J. Pharmacol Exp Ther 283:1460-1468
19. Schwerdt G, Gekle M, Freudinger R, Mildenberger S, Silbernagl S (1997) Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells. Biochim Biophys Acta 1324:191-199
20. Scott PM, Kanhere SR, Lau BPY, Lewis DA, Hayward S, Ryan JJ, Kuiper-Goodman T (1998) Survey of Canadian human blood plasma for ochratoxin A. Food Addit Contam 15:555-562
21. Simon P (1996) Ochratoxin and kidney disease in the human. J Toxicol 15:239-249
22. Song J, Hu X, Khan O, Tian Y, Verbalis JG, Ecelbarger CA (2004) Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin-escape. Am J Physiol 10.1152/ajprena100075.2004
23. Ussing HH, Zerahn K (1951) Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand 23:110-127