Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor

British Journal of Haematology

Volumn 129, Issue 2, 2005, Pages 275-278

  Cario, Gunnar ^a   Skokowa, Julia ^a   Wang, Zheng ^a   Bucan, Vesna ^a   Zeidler, Cornelia ^a   Stanulla, Martin ^a   Schrappe, Martin ^a   Welte, Karl ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Apoptosis; bcl 2 family members; Granulocyte colony stimulating factor; Myeloid progenitor cells; Severe congenital neutropenia

Indexed keywords

CD33 ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN BCL 2; PROTEIN BCL XL; RNA;

ADULT; APOPTOSIS; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HUMAN; INFANT; LEUKOCYTE COUNT; MALE; MYELOID PROGENITOR CELL; NEUTROPENIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; BCL-X PROTEIN; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CASPASE 9; CASPASES; CHILD, PRESCHOOL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INFANT; MALE; MYELOID PROGENITOR CELLS; NEOPLASM PROTEINS; NEUTROPENIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STIMULATION, CHEMICAL;

EID: 17644389497     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05428.x     Document Type: Article

References (12)

1. Ancliff, P.J., Gale, R.E., Liesner, R., Hann, I.M. & Linch, D.C. (2001) Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. Blood, 98, 2645-2650.
2. Aprikyan, A.A., Kutyavin, T., Stein, S., Aprikian, P., Rodger, E., Liles, W.C., Boxer, L.A. & Dale, D.C. (2003) Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia. Experimental Hematology, 31, 372-381.
3. Bellanne-Chantelot, C., Clauin, S., Leblanc, T., Cassinat, B., Rodrigues-Lima, F., Beaufils, S., Vaury, C., Barkaoui, M., Fenneteau, O., Maier-Redelsperger, M., Chomienne, C. & Donadieu, J. (2004) Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register. Blood, 103, 4119-4125.
4. Carlsson, G., Aprikyan, A.A., Tehranchi, R., Dale, D.C., Porwit, A., Hellstrom-Lindberg, E., Palmblad, J., Henter, J.I. & Fadeel, B. (2004) Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood, 103, 3355-3361.
5. Chuang, P.I., Yee, E., Karsan, A., Winn, R.K. & Harlan, J.M. (1998) A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils. Biochemical and Biophysical Research Communications, 249, 361-365.
6. Dale, D.C., Person, R.E., Bolyard, A.A., Aprikyan, A.G., Bos, C., Bonilla, M.A., Boxer, L.A., Kannourakis, G., Zeidler, C., Welte, K., Benson, K.F. & Horwitz, M. (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood, 96, 2317-2322.
7. Devriendt, K., Kim, A.S., Mathijs, G., Frints, S.G., Schwartz, M., Van Den Oord, J.J., Verhoef, G.E., Boogaerts, M.A., Fryns, J.P., You, D., Rosen, M.K. & Vandenberghe, P. (2001) Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia. Nature Genetics, 27, 313-317.
8. Kostmann, R. (1956) Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria. Acta Paediatrica, 45, 1-78.
9. Moulding, D.A., Quayle, J.A., Hart, C.A. & Edwards, S.W. (1998) Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood, 92, 2495-2502.
10. Oberhammer, F., Wilson, J.W., Dive, C. Morris, I.D., Hickman, J.A., Wakeling, A.E., Walke, P.R. & Sikorska, M. (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO Journal, 12, 3679-3684.
11. Person, R.E., Li, F.Q., Duan, Z., Benson, K.F., Wechsler, J., Papadaki, H.A., Eliopoulos, G., Kaufman, C., Bertolone, S.J., Nakamoto, B., Papayannopoulou, T., Grimes, H.L. & Horwitz, M. (2003) Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nature Genetics, 34, 308-312.
12. Welte, K. & Boxer, L.A. (1997) Severe chronic neutropenia: pathophysiology and therapy. Seminars in Hematology, 34, 267-278.