Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm

Journal of Applied Physiology

Volumn 98, Issue 5, 2005, Pages 1753-1760

  Wright, V P ^a,b   Klawitter, P F ^a,b,c   Iscru, D F ^a,b   Merola, A J ^a,b   Clanton, T L ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

4,5 dihydroxy 1,3 benzenedisulfonic acid; Calcium regulation; Mn(III)tetrakis(1 methyl 4 pyridyl) porphyrin pentachloride; N acetylcysteine; Skeletal muscle

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CALCIUM; CREATINE PHOSPHATE; MANGENESE TETRAKIS(1 METHYL 4 PYRIDYL)PORPHYRIN PENTACHLORIDE; PHOSPHATE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; TIRON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DISEASE SEVERITY; EXTRACELLULAR CALCIUM; HIGH ENERGY PHOSPHATE; HYPOXIA; MALE; MUSCLE CONTRACTION; MUSCLE CONTRACTURE; MUSCLE EXCITATION; MUSCLE TETANIC CONTRACTION; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL HYPOXIA; DIAPHRAGM; ENERGY METABOLISM; FREE RADICAL SCAVENGERS; MALE; MUSCLE CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 17644369640     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01022.2004     Document Type: Article

References (41)

1. 2+ release from the sarcoplasmic reticulum. Mol Cell Biochem 82: 81-84, 1988.
2. Arumona OI, Halliwell B, Hoey BM, and Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Radic Biol Med 6: 593-597, 1989.
3. 2+-pump isoform SERCA3a is more resistant to superoxide damage than SERCA2b. Mol Cell Biochem 203: 17-21, 2000.
4. Bergmeyer HU (Editor). Methods of Enyzmatic Analysis (3rd ed.). Deer-field Beach, FL: Verlag Chemie, 1985.
5. Blair AS, Hajduch E, Litherland GJ, and Hundal HS. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways. J Biol Chem 274: 36293-36299, 1999.
6. Day BJ, Fridovich I, and Crapo JD. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 347: 256-262, 1997.
7. 2+ store in skeletal muscle. J Biol Chem 277: 5275-5284, 2002.
8. De Paula Brotto M, van Leyen SA, Brotto LS, Jin JP, Nosek CM, and Nosek TM. Hypoxia/fatigue-induced degradation of troponin I and troponin C: new insights into physiologic muscle fatigue. Pflügers Arch 442: 738-744, 2001.
9. Depre C, Rider MH, and Hue L. Mechanisms of control of heart glycolysis. Eur J Biochem 258: 276-290, 1998.
10. Depre C, Vanoverschelde JL, Goudemant JF, Mottet I, and Hue L. Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in perfused rabbit heart. Circulation 92: 1911-1918, 1995.
11. Diaz PT, Brownstein E, and Clanton TL. Effects of N-acetylcysteine on in vitro diaphragm function are temperature dependent. J Appl Physiol 77: 2434-2439, 1994.
12. 2+ regulation by the sarcoplasmic reticulum in mechanically skinned rat skeletal muscle fibers. J Physiol 517: 447-458, 1999.
13. Esau SA. Role of adenosine in the depolarization of hypoxic hamster diaphragm membrane in vitro. Am J Respir Crit Care Med 149: 910-914, 1994.
14. Eu JP, Hare JM, Hess DT, Skaf M, Sun J, Cardenas-Navina I, Sun QA, Dewhirst M, Meissner G, and Stamler JS. Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. Proc Natl Acad Sci USA 100: 15229-15234, 2003.
15. 2 sensor and NO signaling functions. Cell 102: 499-509, 2000.
16. Faulkner KM, Liochev SI, and Fridovich I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269: 23471-23476, 1994.
17. Fiske CH and Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem 66: 375-400, 1925.
18. Ferrer-Sueta G, Batinic-Haberle I, Spasojevic I, Fridovich I, and Radi R. Catalytic scavenging of peroxynitrite by isomeric Mn(III) N- methylpyridylporphyrins in the presence of reductants. Chem Res Toxicol 12: 442-449, 1999.
19. Gardner PR, Nguyen DD, and White CW. Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells. Arch Biochem Biophys 325: 20-28, 1996.
20. Godt RE and Nosek TM. Changes in intracellular milieu with fatigue or hypoxia depress contraction of skinned rabbit skeletal and cardiac muscle. J Physiol 412: 155-180, 1989.
21. Greenstock CL and Miller RW. The oxidation of Tiron by superoxide anion: kinetics of the reaction in aqueous solution and in chloroplasts. Biochim Biophys Acta 396: 11-16, 1975.
22. Henry PD, Schuchleib R, Davis J, Weiss ES, and Sobel BE. Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am J Physiol Heart Circ Physiol 233: H677-H684, 1977.
23. Heunks LM, Machiels HA, de Abreu M, Zhu XP, van der Heijden HF, and Dekhuijzen PN. Free radicals in hypoxic rat diaphragm contractility: no role for xanthine oxidase. Am J Physiol Lung Cell Mol Physiol 281: L1402-L1412, 2001.
24. Klawitter PF and Clanton TL. Tension-time index, fatigue, and energetics in isolated diaphragm: a new experimental model. J Appl Physiol 96: 89-95, 2004.
25. Klawitter PF, Murray HN, Clanton TL, and Angeles MG. Reactive oxygen species generated during myocardial ischemia enable energetic recovery during reperfusion. Am J Physiol Heart Circ Physiol 283: H1656-H1661, 2002.
26. Kowaltowski AJ and Vercesi AE. Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 26: 463-471, 1999.
27. Krishna CM, Liebmann JE, Kaufman D, DeGraff W, Hahn SM, McMurry T, Mitchell JB, and Russo A. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys 294: 98-106, 1992.
28. Kwali FA and Reid MB. N-acetylcysteine depressed contractile function and inhibits fatigue of diaphragm in vitro. J Appl Physiol 77: 317-324, 1994.
29. Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, and Häussinger D. Functional significance of cell volume regulatory mechanisms. Physiol Rev 78: 247-306, 1998.
30. Lawler JM, Powers SK, Dijk HV, Visser T, Kordus MJ, and Ji LL. Metabolic and antioxidant enzyme activities in the diaphragm: effects of acute exercise. Respir Physiol 96: 139-149, 1994.
31. Lee JH and Park JW. A manganese porphyrin complex is a novel radiation protector. Free Radic Biol Med 37: 272-283, 2004.
32. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ. Protein measurement with Polin phenol reagent. J Biol Chem 193: 265-275, 1951.
33. López-Barneo J, del Toro R, Levitsky KL, Chiara MD, and Ortega-Sáenz P. Regulation of oxygen sensing by ion channels. J Appl Physiol 96: 1187-1195, 2004.
34. Mohanraj P, Merola AJ, Wright VP, and Clanton TL. Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions. J Appl Physiol 84: 1960-1966, 1998.
35. Ovádi J and Saks V. On the origin of intracellular compartmentation and organized metabolic systems. Mol Cell Biochem 256/257: 5-12, 2004.
36. Ørtenblad N, Young JF, Oksbjerg N, Nielsen JH, and Lambert IH. Reactive oxygen species are important mediators of taurine release from skeletal muscle cells. Am J Physiol Cell Physiol 284: C1362-C1373, 2003.
37. Reid MB, Khawli F, and Moody MR. Reactive oxygen in skeletal muscle III. Contractility of unfatigued muscle. J Appl Physiol 75: 1081-1087, 1993.
38. Richardson RS, Noyszewski EA, Saltin B, and Gonzalez-Alonso J. Effect of mild carboxy-hemoglobin on exercising skeletal muscle: intravascular and intracellular evidence. Am J Physiol Regul Integr Comp Physiol 283: R1131-R1139, 2002.
39. Richmond KN, Burnite S, and Lynch RM. Oxygen sensitivity of mitochondrial metabolic state in isolated skeletal and cardiac myocytes. Am J Physiol Cell Physiol 273: C1613-C1622, 1997.
40. Salama G, Menshikova EV, and Abramson JJ. Molecular interaction between nitric oxide and ryanodine receptors of skeletal and cardiac sarcoplasmic reticulum. Antioxid Redox Signal 2: 5-16, 2000.
41. 2+-ATPase of vascular smooth muscle sarcoplasmic reticulum by reactive oxygen intermediates. Am J Physiol Heart Circ Physiol 261: H568-H574, 1991.