Tumor necrosis factor, interleukin-6, and epinephrine are associated with hypermetabolism in AIDS patients with acute opportunistic infections

Annals of Nutrition and Metabolism

Volumn 44, Issue 2, 2000, Pages 43-53

  Süttmann, Ulrich ^a   Holtmannspötter, Markus ^a   Ockenga, Johann ^a   Gallati, Harald ^b   Deicher, Helmuth ^a   Selberg, Oliver ^c  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acquired immunodeficiency syndrome; Epinephrine; Human immunodeficiency virus; Tumor necrosis factor; Tumor necrosis factor receptors

Indexed keywords

ADRENALIN; INTERLEUKIN 6; ISOPROTEIN; NORADRENALIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADRENALIN RELEASE; ADULT; ARTICLE; BODY COMPOSITION; CATECHOLAMINE EXCRETION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENERGY EXPENDITURE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERMETABOLISM; MALE; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 17544399213     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000012820     Document Type: Article

References (55)

1. Macallan DC, Noble C, Baldwin C, Jebb SA, Prentice AM, Coward WA, Sawyer MB, McManus TJ, Griffin GE: Energy expenditure and wasting in human immunodeficiency virus infection. N Engl J Med 1995;333:83-88.
2. Heijligenberg R, Romijn JA, Westerterp KR, Jonkers CF, Prins JM, Sauerwein HP: Total energy expenditure in human immunodeficiency virus-infected men and healthy controls. Metabolism 1997;46:1324-1326.
3. Coors M, Trimborn P, Süttmann U, Henkel E, Selberg O: Energy balance, acute-phase response, heart rate and physical activity in stable immunodeficiency virus infected patients. JPEN 1999;23:59/35.
4. Süttmann U, Ockenga J, Selberg O, Hoogestraat L, Deicher H, Müller MJ: Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus-infected outpatients. J Acquir Immune Defic Syndr Hum Retrovir 1995;8:239-246.
5. Grunfeld C, Kotler DP: Wasting in the acquired immunodeficiency syndrome. Semin Liver Dis 1992;12:175-187.
6. Navikas V, Link J, Persson C, Olsson T, Hojeberg B, Ljungdahl A, Link H, Wahren B: Increased m-RNA expression of IL-6, 1L-10, TNF-alpha, and perform in blood mononuclear cells in human HIV infection. J Acquir Immune Defic Hum Retrovir 1995;9:484-489.
7. Van der Poll T, Romijn JA, Endert E, Borm JJ, Büller HR, Sauerwein HP: Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 1991;261:E457-465.
8. Stouthard JM, Romjin JA, Van der Poll T, Endert E, Klein S, Bakker PJ, Veenhof CH, Sauerwein HP: Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol 1995;268:E813-E819.
9. Reddy MM, Sorrell SJ, Lange M, Grieco MH: Tumor necrosis factor and HIV p24 antigen in the serum of HIV-infected population. J Acquir Immune Defic Syndr Hum Retrovir 1988; 1:436-440.
10. Grunfeld C, Kotler DP, Shigenaga JK, Doerrler W, Tierney A, Wang J, Pierson RN, Feingold KR: Circulating interferon alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med 1991; 90:154-162.
11. Grunfeld C, Pang M, Doerrler W, Shigenaga JK, Jensen P, Feingold KR: Lipids, lipoproteins, triglyceride clearance and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 1992;74:1045-1052.
12. Süttmann U, Selberg O, Gallati H, Ockenga J, Deicher H, Müller MJ: Tumour necrosis factor receptor levels are linked to the acute-phase response and malnutrition in human-immunodeficiency-virus-infected patients. Clin Sci 1994;86:461-467.
13. Gehr G, Braun T, Lesslauer W: Cytokines, receptors and inhibitors. Clin Invest 1992;70: 64-69.
14. Waage A, Halstensen A, Espevik T: Association between tumor necrosis factor in serum and fatal outcomes in patients with meningococcal disease. Lancet 1987;i:355-357.
15. Girardin E, Grau GE, Dayer JM, Roux-Lombard P, Lambert PH: Tumor necrosis factor and interleukin 1 in the serum of children with severe infectious purpura. N Engl J Med 1988; 319:397-400.
16. Scuderi P, Sterling KE, Lam KS, Finley PR, Ryan KJ, Ray CG, Petersen E, Slymen DJ, Salmon SE: Raised serum levels of tumor necrosis factor in parasitic infections. Lancet 1986;ii: 1364-1365.
17. Kalinkovich A, Engelmann H, Harpaz N, Burstein R, Barak V, Kalickman I, Wallach D, Bentwich Z: Elevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection. Clin Exp Immunol 1992;89:351-355.
18. Kalinkovich A, Geleziunas R, Kemper O, Belenki D, Wallach D, Wainberg MA, Bentwich Z: Increased soluble tumor necrosis factor receptor expression and release by human immunodeficiency virus type 1 infection. J Interferon Cytokine Res 1995;15:749-757.
19. Redfield RR, Wright DC, Tramont EC: The Walter Reed staging classification for HTLV-III/LAV infection. N Engl J Med 1986;314: 131-132.
20. Anonymus: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR Morb Mortal Wkly Rep 1987;36(suppl 1S):1S-15S.
21. Selberg O, Süttmann U, Melzer A, Deicher H, Müller MJ, Henkel E, McMillan DC: Effect of increased protein intake and nutritional status on whole body protein metabolism of AIDS patients with weight loss. Metabolism 1995;44: 1159-1165.
22. Süttmann U, Müller MJ, Ockenga J, Hoogestraat L, Coldewey R, Schedel I, Deicher H: Malnutrition and immune dysfunction in patients infected with human immunodeficiency virus. Klin Wochenschr 1991;69:156-162.
23. Ott M, Lembeke B, Fischer H, Jäger R, Polat H, Geier H, Rech M, Staszewski S, Helm EB, Caspary WF: Early changes of body composition in human immunodeficiency virus-infected patients: Tetrapolar body impedance analysis indicates significant malnutrition. Am J Clin Nutr 1993;57:15-19.
24. Sluys TEMS, v.d. Ende ME, Swart GR, van den Berg JWO, Wilson JHP: Body composition in patients with acquired immunodeficiency syndrome: A validation study of bioelectric impedance analysis. J Parent Enteral Nutr 1993; 17:404-406.
25. Harris RA, Benedict FG: A Biometric Study of Basal Metabolism in Man. Washington, Carnegie Institute of Washington 1919, publ 279.
26. Süttmann U, Ockenga J, Hoogestraat L, Selberg O, Schedel I, Deicher H, Müller MJ: Resting energy expenditure and weight loss in human immunodeficiency virus-infected patients. Metabolism 1993;42:1173-1179.
27. Engelberts I, Stephens S, Francot GJM, van der Linden CJ, Buurman WA: Evidence for different effects of soluble TNF-receptors on various TNF measurements in human biological fluids (letter). Lancet 1991;ii:515-516.
28. Bienvenu J, Coulon I, Doche C, Gutowski MC, Grau GE: Analytical performances of commercial ELISA-kits for IL-2, IL-6 and TNF-alpha: A WHO study. Eur Cytokine Netw 1993;4: 447-451.
29. Rathge D: Methodische Untersuchungen zur Bestimmung der Katecholamine aus biologischen Flüssigkeiten. Anwendung auf pathologische und klinisch-phannakologische Frage stellungen; thesis, University of Stuttgart, Germany.
30. Lähdevirta J, Maury CPJ, Teppo AM, Repo H: Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988;85: 289-291.
31. Lautz M, Malik S, Slevin ML, Olsson I: Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans. Cytokine 1990;2:402-406.
32. Winzen R, Wallach D, Kemper O, Resch K, Holtmann H: Selective up-regulation of the 75-kDa tumor necrosis factor (TNF) receptor and its mRNA by TNF and IL-1. J Immunol 1993; 150:4346-4353.
33. Kalthoff H, Roeder C, Brockhaus M, Thick HG, Schmiegel W: Tumor necrosis factor (TNF) up-regulates the expression of p75 but not p55 TNF receptors, and both receptors mediate, independently of each other, up-regulation of transforming growth factor and epidermal growth factor receptor mRNA. J Biol Chem 1993;268:2762-2766.
34. Porteu F, Nathan C: Shedding of tumor necrosis factor receptors by activated human neutrophils. J Exp Med 1990;172:599-607.
35. Diez-Ruiz A, Tilz GP, Zangerle R, Baier-Bitterlich G, Wachter H, Fuchs D: Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis. Eur J Haematol 1995;54:1-8.
36. Zangerle RH, Gallati H, Sarcletti M, Weiss G, Denz H, Wachter H, Fuchs D: Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation. J Acquir Immune Defic Syndr Hum Retrovirol 1994;7:79-85.
37. Thea DM, Porat R, Nagimbi K, Baangi M, St. Louis ME, Kaplan G, Dinarello CA, Keusch GT: Plasma cytokines, cytokine antagonists, and disease progression in African women infected with HIV-1. Ann Intern Med 1996;124: 757-762.
38. Aukrust P, Liabakk NB, Müller F, Lien E, Espevik T, Fröland SS: Serum levels of tumor necrosis factor (TNF) and soluble TNF receptors in human immunodeficiency virus type 1 infection: Correlations to clinical, immunologic, and virologic parameters. J Infect Dis 1994;169:420-424.
39. Hommes MJ, Romijn JA, Endert E, Sauerwein HP: Resting energy expenditure and substrate oxidation in human immunodeficiency virus (HIV)-infected asymptomatic men: HIV affects host metabolism in the early asymptomatic state. Am J Clin Nutr 1991;54:311-315.
40. Selberg O: Schätzung und Messung des Energieverbrauchs: Methodische Aspekte. Akt Ernähr-Med 1995;20:146-156.
41. Matthews DS, Bullock RE, Matthews JN, Aynsley-Green A, Eyre JA: Temperature response to severe head injury and the effect of body energy expenditure and cerebral oxygen consumption. Arch Dis Child 1995;72:507-515.
42. Tracey KJ, Lowry SF, Fahey TJ, Albert JD, Fong Y, Hesse D, Beutler B, Manogue KR, Calvano S, Wei H, Cerami A, Shires GT: Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 1987;164:415-422.
43. Starnes HF, Warren RS, Jeevanandam M, Gabrilove JL, Larchian W, Oettgen HF, Brennan MF: Tumor necrosis factor and the acute metabolic response to tissue injury in man. J Clin Invest 1988;82:1321-1325.
44. van der Poll T, Romijn JA, Endert E, Borm JJJ, Büller HR, Sauerwein HP: Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 1991;261:E457-E465.
45. van der Poll T, Jansen J, Endert E, Sauerwein HP, Deventer SJH: Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood. Infect Immun 1994;62:2046-2050.
46. 2-adrenoreceptor activation. Am J Physiol 1997;273:E1203-E1208.
47. Grunfeld C, Feingold KR: Metabolic disturbances and wasting in the acquired immunodeficiency syndrome. N Engl J Med 1992;327: 329-337.
48. Hommes MJT, Romijn JA, Endert E, Sauerwein HP: Resting energy expenditure and substrate oxidation in human immunodeficiency virus (HIV)-infected asymptomatic men: HIV affects host metabolism in the early asymptomatic stage. Am J Clin Nutr 1991;54:311-315.
49. Hommes MJT, Romjin JA, Godfried MH, Eeftinck Schattenkerk JKM, Buurman WA, Endert E, Sauerwein HP: Increased resting energy expenditure in human immunodeficiency virus-infected men. Metabolism 1990;39:1186-1190.
50. Heijligenberg R, Romijn JA, Klein S, Endert E, Sauerwein HP: Lipolytic sensitivity to catecholamines in patients with human immunodeficiency virus infection. Am J Clin Nutr 1997;66:633-638.
51. Elbron JS, Cordon SM, Western PJ, Macdonald IA, Shale DJ: Tumour necrosis factor, resting energy expenditure and cachexia in cystic fibrosis. Clin Sci 1993;85:563-568.
52. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ, Zhuang H, Dawson-Hughes B, Dinarello CA, Rosenberg IH: Rheumatoid cachexia: Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994;93:2379-2386.
53. Hardin TC, Koeller JM, Kuhn JG, Roodman GD, von-Hoff DD: Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-alpha. J Parenter Enteral Nutr 1993;17:541-545.
54. Godfried MH, Romijn JA, v.d. Poll T, Weverling GJ, Corssmit EPM, Endert E, Eeftinck Schattenkerk JK, Sauerwein HP: Soluble receptors for tumor necrosis factor are markers for clinical course but not for major metabolic changes in human immunodeficiency virus infection. Metabolism 1995;44:1564-1569.
55. Moore FD, Oleson KH, McMurrey JD, Parker HV, Ball MR, Boyden CM: The Body Cell Mass and Its Supporting Environment. Philadelphia, Saunders, 1963.