Pharmacokinetics of three doses of once-weekly fluconazole (150, 300, and 450 mg) in distal subungual onychomycosis of the toenail

Journal of the American Academy of Dermatology

Volumn 38, Issue 6 II, 1998, Pages

  Rich, P ^a   Scher, R K ^a   Breneman, D ^a   Savin, R C ^a   Feingold, D S ^a   Konnikov, N ^a   Shupack, J L ^a   Pinnell, S ^a   Levine, N ^a   Lowe, N J ^a   Aly, R ^a   Odom, R B ^a   Greer, D L ^a   Morman, M R ^a   Bucko, A D ^a   Tschen, E H ^a   Elewski, B E ^a   Smith, E B ^a   Hilbert, J ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; FLUCONAZOLE; GRISEOFULVIN; ITRACONAZOLE; KETOCONAZOLE; TERBINAFINE;

CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDICATION; DRUG PENETRATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; ONYCHOMYCOSIS; ORAL DRUG ADMINISTRATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; TREATMENT OUTCOME;

EID: 17544386618     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0190-9622(98)70493-1     Document Type: Review

References (23)

1. N Zaias B Glick G. Rebell Diagnosing and treating onychomycosis J Fam Pract 42 1996 513 518
2. RB. Odom New therapies for onychomycosis J Am Acad Dermatol 35 1996 S26 S30
3. G Cauwenbergh H Degreef J Heykants Pharmacokinetic profile of orally administered itraconazole in human skin J Am Acad Dermatol 18 1988 263 268
4. J Faergemann H Zehender J Denouël L. Millerioux Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once per day for four weeks Acta Derm Venereol 73 1993 305 309
5. J Faergemann H Zehender L. Millerioux Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once daily for 7 and 14 days Clin Exp Dermatol 19 1994 121 126
6. JM Kovarik EA Mueller H Zehender J Denouel H Caplain L Millerioux Multiple-dose pharmacokinetics and distribution in tissue of terbinafine and metabolites Antimicrob Agents Chemother 39 1995 2738 2741
7. AY. Finley Pharmacokinetics of terbinafine in the nail J Dermatol Treat 3 suppl 1 1992 15 17
8. RJ. Hay Onychomycosis. Agents of choice Dermatol Clin 11 1993 161 169
9. N. Zaias Onychomycosis Dermatol Clin 3 1985 445 460
10. V. Barranco New approaches to the diagnosis and management of onychomycosis Int J Dermatol 33 1994 292 299
11. L Matthieu P De Doncker G Cauwenbergh R Woestenborghs V van de Velde PA Janssen Itraconazole penetrates the nail via the nail matrix and the nail bed — an investigation in onychomycosis Clin Exp Dermatol 16 1991 374 376
12. M Willemsen P De Doncker J Willems Posttreatment itraconazole levels in the nail J Am Acad Dermatol 26 1992 731 735
13. PJ Dykes R Thomas AY. Finlay Determination of terbinafine in nail samples during systemic treatment for onychomycosis Br J Dermatol 123 1990 481 486
14. KW Brammer PR Farrow JK. Faulkner Pharmaco-kinetics and tissue penetration of fluconazole in humans Rev Infect Dis 12 suppl 3 1990 S318 S326
15. SM Grant SP. Clissold Fluconazole, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses Drugs 39 1990 877 916
16. D Debruyne J-P. Ryckelynck Clinical pharmacokinetics of fluconazole Clin Pharmacokinet 24 1993 10 27
17. CM Perry R Whittington D. McTavish Fluconazole: an update of its antimicrobial activity, pharmacokinetic properties, and therapeutic use in vaginal candidiasis Drugs 49 1995 984 1006
18. DW. Warnock New pharmacological concepts in antimycotic treatment J Eur Acad Dermatol Venereol 2 1993 S19 S25
19. RJ. Hay Pharmacokinetic evaluation of fluconazole in skin and nails Int J Dermatol 31 suppl 2 1992 6 7
20. J Faergemann H. Laufen Levels of fluconazole in normal and diseased nails during and after treatment of onychomycoses in toe-nails with fluconazole 150 mg once weekly Acta Dermatol Venereol (Stockh) 76 1996 219 221
21. J Fräki H Heikkila M Kero K Kuokkanen R Oksman T Rautanen Dermatology 2000 Abstract 14 1993
22. RK Scher D Breneman P Rich RC Savin DS Feingold N Konnikov Once-weekly fluconazole (150 mg, 300 mg, or 450 mg) in the treatment of distal subungual onychomycosis of the toenail J Am Acad Dermatol 38 1998 S77 S86
23. CA Oyeka HC. Gugnani In vitro activity of seven azole compounds against some clinical isolates of nondermatophyte filamentous fungi and some dermatophytes Mycopathologia 110 1990 157 161