Experimental estimation of effective transport coefficients in freeze drying for simulaton and optimization purposes

Drying Technology

Volumn 14, Issue 3-4, 1996, Pages 743-763

  Lombrana J I ^a   Izkara, J ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Freeze drying; Process control; Sublimation temperature; Transport coefficients

Indexed keywords

EID: 17544383116     PISSN: 07373937     EISSN: None     Source Type: Journal    
DOI: 10.1080/07373939608917123     Document Type: Article

References (13)

1. Jiménez L. and J.I. Lombraña, 1983: Influencia de las variables del proceso sobre el tiempo de secado por liofilización del zumo de zanahoria. An. Quím., 79, 101-107.
2. Lombraña J.I. and J.M. Dí;az, 1987: Heat Programming to Improve Efficiency in a Batch Freeze-Drier, The Chemical Engineering Journal, 35, B23-B30.
3. Millman M.J., A.I. Liapis and J.M. Marchello, 1985: An Analysis of the Lyophilization Process Using a Sorption-Sublimation Model and Various Operational Policies, AIChE Journal, 31, 10, 1594-1604.
4. Nail S.L. and L.A. Gatlin, 1985: Advances in Control of Production Freeze Dryers, Journal of Parenter. Sci. and Technol., 39, 16-27.
5. Sui Lin, 1992: The Characteristics of Thermal Control of Freeze-Drying Processes in Porous Plates, Cylinders and Spheres, "Drying '92", ed. by A.S. Mujumdar, p. 384-393, Elsevier.
6. Williams, N.A. and G.P. Polli, 1984: The Lyophilization of Pharmaceuticals: A Literature Review, Journal of Parenter. Sci. and Technol., 38, 48-59.
7. Lombrana J.I. and M. Díaz, 1987: Coupled Vacuum and Heating Power Control for Freeze-Drying Time Reduction of Solutions in Vials, Vacuum, 37 (5-6), 473-476.
8. Litchfield R.J., A.I. Liapis and F.A. Farhadpour, 1981: Cycled Pressure and Near-Optimal Pressure Policies for a Freeze Dryer, J. Food Technol., 16, 637-646.
9. a Ed., McGraw Hill.
10. King, V.E., R.R. Zall and D.C. Ludington, 1989: Controlled Low-Temperature Vacuum Dehydration.- A New Approach for Low-Temperature and Low-Pressure Food Drying, Journal of Food Science, 54 (6), pp. 1573-1579.
11. Flink, J.M., J. Hawles , H. Chen and E. Wong, 1974: Properties of the Freeze-drying "Scorch" Temperature, Journal of Food Science, 39, pp. 1244-1246.
12. Bruttini, R., G. Rovero and G. Saldi, 1991: Experimentation and Modelling of Pharmaceutical Lyophilization Using a Pilot Plant, The Chemical Engineering Journal, 45, B67-B77.
13. Kumagai H., K. Nakamura and T. Yano, 1991: Rate Analysis of Freeze-Drying of a Model System by a Uniformly Retreating Ice Front Model, Agric. Biol. Chem., 55 (3), pp. 731-736.