Sex hormones in patients with epilepsy - Hormonal changes in epileptic men and women taking antiepileptics

Hormone and Metabolic Research

Volumn 37, Issue 3, 2005, Pages 184-188

  Ciampani, M ^a   Verrotti, A ^a   Chiarelli, Francesco ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Antiepileptic drugs; Carbamazepine; Impaired fertility; Lamotrigine; Sexual development; Valproic acid

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; PHENYTOIN; SEX HORMONE; VALPROIC ACID;

ADULT; ANOVULATION; ARTICLE; CONTROLLED STUDY; ENDOCRINE SYSTEM; EPILEPSY; FEMALE; FEMALE INFERTILITY; GONAD DYSFUNCTION; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; INSULIN RESISTANCE; LIBIDO DISORDER; MAJOR CLINICAL STUDY; MALE; MENSTRUATION DISORDER; NEUROLOGIC DISEASE; OBESITY; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SEIZURE; SEXUAL DEVELOPMENT; SIDE EFFECT; TESTIS FUNCTION; WEIGHT GAIN;

ANTICONVULSANTS; EPILEPSY; FEMALE; GONADAL STEROID HORMONES; HUMANS; INFERTILITY; MALE;

EID: 17544379043     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-861304     Document Type: Article

References (41)

1. Snyder PJ, Badura LL. A potential mechanism of slowed pubertal maturation after chronic administration of sodium valproic acid. Neurology 1998; 50: 922-925
2. Isojärvi JIT, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KTS, Myllyla VV. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 1993; 329: 1383-1388
3. Saunders M, Rawson M. Sexuality in male epileptics. J Neurol Sci 1970; 10: 577-583
4. Taylor DC. Sexual behavior in temporal lobe epilepsy. Arc Neurol 1969; 21: 510-516
5. Morell MJ, Sauer M, Guidice L. Pituitary gonadotropin function in women with epilepsy. Epilepsia 2000; 41 (Suppl 7): 247
6. Drislane FW, Coleman AE, Schomer DL. Altered pulsatile secretion of luteinizing hormone in women with epilepsy. Neurology 1994; 44: 306-310
7. Morell MJ. Reproductive and metabolic disorders in women with epilepsy. Epilepsia 2003; 44 (Suppl 4): 11-20
8. Herzog AG, Coleman AE, Jacobs AR. Menstrual disorders reproductive endocrine dysfunction and interictal discharge frequency in women with temporolimbic epilepsy. Neurology 1999; 52 (Suppl 2): A24
9. Morell MJ, Giudice L, Flynn KL, Seale CG, Paulson AJ, Done S, Flaster E, Ferin M, Sauer MV. Predictors of ovulatory failure in women with epilepsy. Ann Neurol 2002; 52: 704-711
10. Herzog AG, Seibel MM, Schomer DL. Temporal lobe epilepsy: an extra-hypotalamic pathogenesis for polycystic ovarian syndrome? Neurology 1984; 34: 1389-1393
11. Isojärvi JIT, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KTS, Myllyla VV. Polycystic ovaries and hyperandrogenism in women taking valproate. New Engl J Med 1993; 329: 1383-1388
12. Bauer J, Jarred A, Klingmuller D, Elgar CE. Polycystic ovary syndrome in patients with focal epilepsy. A study in 93 women. Epilepsy Res 2000; 41: 163-167
13. Duncan S. Polycystic ovarian syndrome in women with epilepsy: a review. Epilepsia 2001; 42: 60-65
14. Stanhope R, Adams J, Jacobs HS, Brook CGD. Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low dose pulsatile gonadotrophin releasing hormone treatment in hypogondotropic hypogonadism. Arch Dis Child 1985; 60: 116-119
15. Poison DW. Polycystic ovary syndrome and epilepsy a gynaecological perspective. Seizure 2003; 12: 397-402
16. Adams J, Franks S, Poison DW. Multi-follicular ovaries: clinical and endocrine features and response to pulsatile gonadotrophin-releasing hormone. Lancet 1985; 2: 1375-1379
17. Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Meriiam GR. Polycystic ovary syndrome. Oxford: Blackwell Scientific, 1992: 377-384
18. Knochenhauser ES, Key TJ, Kashar-Miller M. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 1998; 83: 3078-3082
19. Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorder in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 341-346
20. Herzog AG, Levesque L, Drislane F, Ronthal M, Schomer D. Phenytoin induced elevations of serum estradiol and reproductive dysfunction in men with epilepsy. Epilepsia 1991; 32: 550-553
21. Herzog AG. A hypothesis to integrate partial seizure of temporal lobe origin and reproductive endocrine disorders. Epilepsy Res 1989; 3: 151-159
22. Murialdo G, Galimberti CA, Fonzi S, Manni R, Costelli P, Parodi C, Solinas GP, Amoretti G, Tartara A. Sex hormones and pituitary function in male epileptic patients with altered or normal sexuality. Epilepsia 1995; 36: 360-366
23. Herzog AG. Reproductive endocrine considerations and hormonal therapy in men with epilepsy. Epilepsy 1991; 32 (Suppl 6): S34-S37
24. Murialdo G, Galimberti CA, Fonzi S, Manni R, Costelli P, Parodi C, Solinas GP, Amoretti G, Tartara A. Sex hormones, gonadotropin and prolactin in male epileptic subject in remission: role of the epileptic syndrome and of antiepileptic drugs. Neuropsycobiol 1994; 30: 29-36
25. Ramsay RE, Salter JD. Effects of antiepileptic drugs on hormones. Epilepsia 1991; 32 (Suppl 6): S60-S67
26. El-Khayat HA, Shatla HM, Ali GKH, Abdulgani MO, Tomoum HY, Attya HA. Physical and hormonal profile of male sexual development in epilepsy. Epilepsia 2003; 44: 447-452
27. Isojärvi JIT, Pakarinen AJ, Schmaltz S. Testosterone levels in adult male epileptic patients. Neurology 1987; 37: 706-708
28. Franceschi M, Perego L, Cavagnini F. Effects of long-term antiepileptic therapy on hypothalamic-pituitary axis in men. Epilepsia 1984; 25: 46-52
29. Kurowski HL, Gospe SMJr, Zeman FJ. Nutritional factors and anticonvulsant therapies: effect on growth in children with epilepsy. Am J Clin Nutr 1993; 58: 858-861
30. Macardle BM, McGowan MEL, Greene SA. Anticonvulsant drugs, growth and development. Arch Dis Child 1987; 62: 615-617
31. Verrotti A, Basciani F, Morresi S, Cutarella R, Morgese G, Chiarelli F. Serum sex hormone levels in young male patients with epilepsy receiving carbamazepine and valproic acid and after their withdrawal. Eur J Ped 2000; 159: 871-872
32. Vainionpää LK, Rättyä J, Knip M, Tapanainen JS, Pakarinen AJ, Lanning P, Tekay A, Myllylä VV, Isojärvi JIT. Valproate induced hyperandrogenism during pubertal maturation in girls with epilepsy. Ann Neurol 1999; 45: 444-450
33. Verrotti A, Basciani F, de Simone M, Trotta D, Morgese G, Chiarelli F. Insulin resistance in epileptic girl who weight gain after therapy with valproic acid. J Child Neurol 2002; 17: 265-268
34. Isojärvi JIT, Laatikainen TJ, Knip M. Obesity and endocrine disorders in women taking valproate for epilepsy. Ann Neurol 1996; 39: 579-584
35. Verrotti A, Basciani F, Morresi S, de Martino M, Morgese G, Chiarelli F. Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. Neurology 1999; 13: 53: 230-232
36. Adkeniz F, Tanelli F, Noyan A, Yuncu Z, Vahip S. Valproate associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women? Prog Neur Biol Psychiatry 2003; 27: 115-121
37. Morell MJ, Isojärvi J, Taylor AE, Dam M, Ayala R, Gomez G, O'Neill F, Tennis P, Messenheimer J. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Res 2003; 54: 189-199
38. Isojärvi JIT, Laatikainen TJ, Parakinen AJ, Juntunen KTS, Myllylä VV. Menstrual disorders in women with epilepsy receiving carbamazepine. Epilepsia 1995; 36: 676-681
39. Pasquali R, Casimirri F. The impact of obesity on hyperandrogenism and polycystic ovary sindrome in premenopausal women. Clin Endocrinol 1993; 39: 1-16
40. Isojärvi JI, Rättyä J, Myllylä W. Valproate, lamotrigine, and insulin mediated risk in women with epilepsy. Ann Neurol 1998; 43: 446-451
41. Betts T, Yarrow H, Dutton N, Greenhill L, Rolfe T. A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. Seizure 2003; 12: 323-329