Glutamate excitotoxicity in glaucoma: Truth or fiction?

Eye

Volumn 19, Issue 4, 2005, Pages 369-370

  Lotery, A J ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; CALCIUM ION; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

CALCIUM CELL LEVEL; CENTRAL RETINA ARTERY OCCLUSION; CLINICAL TRIAL; EDITORIAL; EVIDENCE BASED MEDICINE; EXCITOTOXICITY; GLAUCOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAOCULAR HYPERTENSION; MENIERE DISEASE; NERVE CELL NECROSIS; NEUROTRANSMISSION; NONHUMAN; RETINA DEGENERATION; RETINA GANGLION CELL; SYNAPTIC TRANSMISSION; VITREOUS BODY;

EID: 17544367199     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.eye.6701623     Document Type: Editorial

References (19)

1. Vorwerk CK, Gorla MS, Dreyer EB. An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. Surv Ophthalmol 1999; 43 (Suppl 1): S142-S150.
2. Department of Health Human Services. Findings of scientific misconduct 2000. http://grants.nih.gov/grants/guide/notice-files/NOT-OD-01-006.html
3. Dalton R. Private investigations. Nature 2001; 411 129-130.
4. Kemp JA, McKernan RM. NMDA receptor pathways as drug targets. Nat Neurosci 2002; 5 (Suppl): 1039-1042.
5. Sucher NJ, Wong LA, Lipton SA. Redox modulation of NMDA receptor-mediated Ca2+ flux in mammalian central neurons. Neuroreport 1990; 1: 29-32.
6. Sucher NJ, Aizenman E, Lipton SA. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci 1991; 11: 966-971.
7. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623-634.
8. Hahn JS, Aizenman E, Lipton SA. Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801. Proc Natl Acad Sci USA 1988; 85: 6556-6560.
9. Sucher NJ, Lei SZ, Lipton SA. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res 1991; 551: 297-302.
10. Kemp JA, Kew JNC, Gill R, Jones P, Monyer H. Handbook of Experimental Pharmacology. Handbook of Exp Pharmacol 1999; 141 495-527.
11. Lees KR, Asplund K, Carolei A, Davis SM, Diener HG, Kaste M et al. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators. Lancet 2000; 355: 1949-1954.
12. Sacco RL, DeRosa JT, Haley EC Jr, Levin B, Ordronneau P, Phillips SJ et al. Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial. JAMA 2001; 285: 1719-1728.
13. Lucas DR, Newhouse JP. The toxic effect of sodium L-glutamate on the inner layers of the retina. Ama Arch Opthalmol 1957; 58 193-201.
14. Azuma N, Kawamura M, Kohsaka S. Morphological and immunohistochemical studies on degenerative changes of the retina and the optic nerve in neonatal rats injected with monosodium-L-glutamate. Nippon Ganka Gakkai Zasshi 1989; 93: 72-79.
15. Siliprandi R, Canella R, Carmignoto G, Schiavo N, Zanellato A, Zanoni R et al. N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina. Vis Neurosci 1992; 8: 567-573.
16. Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA. Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996; 114: 299-305.
17. Brooks DE, Garcia GA, Dreyer EB, Zurakowski D, Franco-Bourland RE. Vitreous body glutamate concentration in dogs with glaucoma. Am J Vet Res 1997; 58: 864-867.
18. Carter-Dawson L, Crawford ML, Harwerth RS, Smith EL 3rd, Feldman R, Shen FF et al. Vitreal glutamate concentration in monkeys with experimental glaucoma. Invest Ophthalmol Vis Sci 2002; 43: 2633-2637.
19. Honkanen RA, Baruah S, Zimmerman MB, Khanna CL, Weaver YK, Narkiewicz J et al. Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy. Arch Ophthalmol 2003; 121 183-188.