Proconvulsant effects induced by pyridoxine in young rats

Epilepsy Research

Volumn 29, Issue 3, 1998, Pages 259-264

  Verešová, Soňa ^a   Kábová, Radka ^a   Velíšek, Libor ^a,b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Development; Seizures; Toxicity; Vitamin B6

Indexed keywords

PYRIDOXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROENCEPHALOGRAM; EPILEPSY; EPILEPTIC DISCHARGE; INTRAPERITONEAL DRUG ADMINISTRATION; NEUROLOGY; NEUROTOXICITY; NONHUMAN; PEDIATRICS; PRIORITY JOURNAL; RAT;

EID: 17444439913     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)00088-0     Document Type: Article

References (22)

1. Bass, N.B., Wyllie, E., Cohen, B., Joseph, A.S., 1996. Pyridoxine-dependent epilepsy: The need for repeated pyridoxine trials and the risk of severe electrocerebral suppression with intravenous pyridoxine infusion. J. Child Neurol. 11, 422-424.
2. Bayley, M., Walsh, F.M., Valaske, M.J., 1975. Fatal overdose from Bendectin. Clin. Pediat. 14, 507-509.
3. Bender, D., 1989. Vitamin B6 requirements and recommendations. Eur. J. Clin. Nutr. 43, 289-309.
4. Blennow, G., Starck, L., 1986. High dose B6 treatment in infantile spasms. Neuropediatrics 17, 7-10.
5. Dordain, G., Deffond, D., 1994. Pyridoxine neuropathies. [Review of the literature]. Therapie 49, 333-337.
6. Ebadi, M., Metzler, D.E., Christenson, W.R., 1983. Convulsant activity of pyridoxal sulphate and phosphonoethyl pyridoxal: antagonism by GABA and its synthetic analogues. Neuropharmacology 22, 865-873.
7. Ebadi, M., Jobe, P.C., Laird, H.E.I., 1985. The status of vitamin B6 metabolism in brains of genetically epilepsyprone rats. Epilepsia 26, 353-359.
8. Gottlieb, A., Keydar, I., Epstain, H.T., 1977. Rodent brain growth stages: An analytical review. Biol. Neonate 32, 166-176.
9. Ishioka, N., Sato, J., Nakamura, J., Ohkubo, T., Takeda, A., Kurioka, S., 1995. In vivo modification of GABAA receptor with a high dose of pyridoxal phosphate induces tonic-clonic convulsion in immature mice. Neurochem. Int. 26, 369-373.
10. Kouyoumdjian, J.C., Ebadi, M., 1981. Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures. J. Neurochem. 36, 251-257.
11. Mikolášová, R., Velíšek, L., Vorlíček, J., Mareš, P., 1994. Developmental changes of ketamine action against epileptic afterdischarges induced by hippocampal stimulation in rats. Brain Res. 81, 105-112.
12. Morra, M., Philipszoon, H.D., Andrea, D.G., Cananzi, A.R., Erario, L.R., Milone, F.F., 1993. Sensory and motor neuropathy caused by excessive ingestion of vitamin B6: a case report. Funct. Neurol. 8, 429-432.
13. Moshé, S.L., Velíšek, L., Holmes, G.L., 1994. Developmental aspects of experimental seizures. In: Genton, P., Hirsch, E., Malafosse, A., Marescaux, C. (Eds.), International Workshop on Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. John Libbey, London, pp. 51-64.
14. Ohtsuka, Y., Matsuda, M., Ogino, T., Kobayashi, K., Ohtahara, S., 1987. Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain Dev. 9, 418-421.
15. Pietz, J., Benninger, C., Schafer, H., Sontheimer, D., Mittermaier, G., Rating, D., 1993. Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia 34, 757-763.
16. Schaeffer, M.C., 1993. Excess dietary vitamin B-6 alters startle behavior of rats. J. Nutr. 123, 1444-1452.
17. Schaumburg, H., Kaplan, J., Windebank, A., Vick, N., Rasmus, S., Pleasure, D., 1983. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. New Engl. J. Med. 309, 445-448.
18. Snodgrass, S.R., 1992. Vitamin neurotoxicity. Mol. Neurobiol. 6, 41-73.
19. Tyl, R.W., Price, C.J., Marr, M.C., Kimmel, C.A., 1988. Developmental toxicity evaluation of Bendectin in CD rats. Teratology 37, 539-552.
20. Waymire, K.G., Mahuren, J.D., Jaje, J.M., Guilarte, T.R., Coburn, S.P., MacGregor, G.R., 1995. Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat. Genet. 11, 45-51.
21. Weigand, C., Eckler, C., Chen, K., 1940. Action and toxicity of vitamin B6 hydrochloride. Proc. Soc. Exp. Biol. Med. 44, 147-151.
22. Windebank, A.J., Low, P.A., Blexrud, M.D., Schmelzer, J.D., Schaumburg, H.H., 1985. Pyridoxine neuropathy in rats: specific degeneration of sensory axons. Neurology 35, 1617-1622.