History of U.S. military contributions to the study of rickettsial diseases

Military Medicine

Volumn 170, Issue 4 SUPPL., 2005, Pages 49-60

  Bavaro, Mary F ^a   Kelly, Daryl J ^b   Dasch, Gregory A ^c   Hale, Braden R ^a   Olson, Patrick ^a  

^a NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CHLORAMPHENICOL; CHLORPHENOTANE; DOXYCYCLINE; RIFAMPICIN; ROCKY MOUNTAINS SPOTTED FEVER VACCINE; SCRUB TYPHUS VACCINE; TETRACYCLINE; TYPHUS VACCINE; UNCLASSIFIED DRUG;

CLINICAL TRIAL; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; EHRLICHIOSIS; HUMAN; INFESTATION; MILITARY MEDICINE; NONHUMAN; PARASITE VECTOR; RICKETTSIOSIS; ROCKY MOUNTAIN SPOTTED FEVER; SCRUB TYPHUS; TYPHUS; UNITED STATES; VACCINATION;

EID: 17444429249     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.7205/MILMED.170.4S.49     Document Type: Conference Paper

References (114)

1. Zinsser H: Rats, Lice, and History. Boston, MA, Little, Brown, 1935.
2. Kelly DJ, Richards AL, Temenak J, Strickman D, Dasch GA: The past and present threat of rickettsial diseases to military medicine and international public health. Clin Infect Dis 2002; 34(Suppl 4): 5145-69.
3. Snyder JC: Typhus fever rickettsiae. In: Viral and Rickettsial Infections of Man, Ed 4, pp 1059-94. Edited by Horsfall FL, Tamm I. Philadelphia, PA, JB Lippincott, 1965.
4. Duma RJ, Sonenshine DE, Bozeman FM, et al: Epidemic typhus in the United States associated with flying squirrels. JAMA 1981; 245: 2318-23.
5. Woodward TE: A historical account of the rickettsial diseases with a discussion of the unsolved problems. J Infect Dis 1973; 127: 583-94.
6. Brown AE, Strickman DA, Kelly DJ: Diseases transmitted by arthropod vectors: typhus. In: Military Preventive Medicine: Mobilization and Deployment: Textbook of Military Medicine. Edited by Kelley P. Washington, DC, Borden Institute, Office of the Surgeon General, Department of the Army, 2004.
7. Moe JB, Pedersen CE: The impact of rickettsial diseases on military operations. Milit Med 1980; 145: 780-5.
8. Tasker AN: Infectious jaundice, typhus fever, trench fever. In: The Medical Department of the United States Army in the World War, Vol 9. Communicable and Other Diseases, pp 483-92. Edited by Ireland MW, Siler JF. Washington, DC, U.S. Government Printing Office, 1928.
9. Zarafonetis CJD: The typhus fevers. In: Internal Medicine in World War II, Vol II. Infectious Diseases, pp 143-223. Edited by Coates JB, Havens WP. Washington, DC, Office of the Surgeon General, Department of the Army, 1963.
10. Scoville AB: Epidemic typhus fever in Japan and Korea. In: Rickettsial Diseases of Man, pp 28-35. Edited by Soule MH. Washington, DC, American Association for the Advancement of Science, 1948.
11. Fuller HS, Smadel JE: Rickettsial diseases and the Korean conflict. In: Recent Advances in Medicine and Surgery Based on Professional Experiences in Japan and Korea, 1950-1953, Vol 2, pp 304-10. Washington, DC, U.S. Army Medical Service Graduate School, Walter Reed Army Medical Center, 1954.
12. Office of the Surgeon General: United States Army: A Summary of Medical Experience in Korea Since July, 1950. IV. Health of the Army. pp 35-40. Washington, DC, Office of the Surgeon General, Department of the Army, 1953.
13. Raoult D, Ndihokubwayo JB, Tissot-Dupont H, et al: Outbreak of epidemic typhus associated with trench fever in Burundi. Lancet 1998; 352: 353-8.
14. Mostofi FK: Contributions of the military to tropical medicine. Bull NY Acad Med 1968; 44: 702-20.
15. Weiss E, Dressler HR: Selection of an erythromycin-resistant s train of Rickettsia prowazekii. Am J Hyg 1960; 71: 292-8.
16. Coolbaugh JC, Progar JJ, Weiss E: Enzymatic activities of cell-free extracts of Rickettsia typhi. Infect Immun 1976; 14: 298-305.
17. Carl M, Dasch GA: The importance of the crystalline surface layer protein antigens of rickettsiae in T-cell immunity. J Autoimmun 1989; 2(Suppl): 81-91.
18. Jiang J, Temenak JJ, Richards AL: Real-time PCR duplex assay for Rickettsia prowazekii and Borrelia recurrentis. Ann NY Acad Sci 2003; 990: 302-10.
19. Azad AF: Epidemiology of murine typhus. Annu Rev Entomol 1990; 35: 553-69.
20. Dumler JS, Taylor JP, Walker DH: Clinical and laboratory features of murine typhus in south Texas, 1980-1987. JAMA 1991; 266: 1365-70.
21. Silpapojakul K: Scrub typhus in the Western Pacific region. Ann Acad Med Singapore 1997; 26: 794-800.
22. Oaks SC Jr, Ridgway RL, Shirai A, Twartz JC: Scrub typhus. In: Bulletin 21. Kuala Lumpur, Malaysia, Institute for Medical Research, 1983.
23. Deaton JG: Febrile illnesses in the tropics (Vietnam). Milit Med 1969; 134: 403-8.
24. Wisseman C: Report of the Commission on Rickettsial Diseases. Armed Forces Epidemiology Board Meeting, December 15, 1972, pp 79-81. Washington, DC, Walter Reed Army Institute of Research, 1972.
25. Corwin AL, Soeprapto W, Widodo PS, et al: Surveillance of rickettsial infections in Indonesian military personnel during peacekeeping operations in Cambodia. Am J Trop Med Hyg 1997; 57: 569-70.
26. Smadel JE, Elisberg BL: Scrub typhus rickettsia. In: Viral and Rickettsial Infections of Man, Ed 4. pp 1130-43. Edited by Horsfall FL, Tamm I. Philadelphia, PA, JB Lippincott, 1965.
27. Smadel JE, Woodward TE, Ley HL, Lewthwaite R: Chloramphenicol (chloromycetin) in the treatment of tsutsugamushi disease (scrub typhus). J Clin Invest 1949; 28: 1196-215.
28. Watt G, Chouriyagune C, Ruangweerayud R, et al: Scrub typhus infections poorly responsive to antibiotics in northern Thailand. Lancet 1996; 348: 86-9.
29. Rosenberg R: Drug resistant scrub typhus: paradigm and paradox. Parasitol Today 1997; 13: 131-2.
30. Tattersall RN: Tsutsugamushi fever on the India-Burma border. Lancet 1945; 2: 392-4.
31. Thompson AH: A new endemic area of scrub typhus in Japan. Bull US Army Med Dept 1949; 9: 871-9.
32. Jiang J, Marienau KJ, May LA, et al: Laboratory diagnosis of two scrub typhus outbreaks at Camp Fuji, Japan, in 2000 and 2001 by ELISA, rapid flow assay, and Western blot assay using outer membrane 56-kD recombinant proteins. Am J Trop Med Hyg 2003; 69: 60-6.
33. Philip CB: Scrub typhus and scrub itch. In: Preventive Medicine in World War II, Vol VII, Communicable Diseases: Arthropodborne Diseases Other than Malaria, pp 275-347. Edited by Coates JB, Hoff EC, Hoff PM. Washington, DC, Office of the Surgeon General, Department of the Army, 1964.
34. Kohls GM, Armbrust CA, Irons EN, Philip CB: Studies on tsutsugamushi disease (scrub typhus, mite-borne typhus) in New Guinea and adjacent islands Republic of the Philippines. Am J Trop Med Hyg 1945; 41: 374-96.
35. Chang WH: Current status of tsutsugamushi disease in Korea. J Korean Med Sci 1995; 10: 227-38.
36. Yi KS, Chong Y, Covington SC, et al: Scrub typhus in Korea: importance of early clinical diagnosis in this newly recognized endemic area. Milit Med 1993; 158: 269-73.
37. Barrett O, Stark FR: Rickettsial diseases and leptospirosis. In: General Medicine and Infectious Diseases, pp 133-62. Edited by Ognibene AF, Barrett O. Washington, DC, Office of the Surgeon General and Center of Military History, Department of the Army, 1982.
38. Deller JJ: Fever of undetermined origin. In: General Medicine and Infectious Diseases, pp 75-90. Edited by Ognibene AF, Barrett O. Washington, DC, Office of the Surgeon General and Center of Military History, Department of the Army, 1982.
39. Dangerfield HG: Some Clinical and Epidemiological Observations on Scrub Typhus in the Republic of Vietnam, Vietnam Report, June 26, 1967. Washington, DC, Department of the Army, U.S. Army Medical Research Team, Walter Reed Army Institute of Research, 1967.
40. Brown GW, Shirai A, Groves MG: Development of antibody to Rickettsia tsutsugamushi in soldiers in Malaysia. Trans R Soc Trop Med Hyg 1983; 77: 225-7.
41. Richards AL, Ratiwayanto S, Rahardjo E, et al: Serologic evidence of infection with ehrlichiae and spotted fever group rickettsiae among residents of Gag Island, Indonesia. Am J Trop Med Hyg 2003; 68: 480-4.
42. Woodward TE: The public's debt to military medicine. Milit Med 1981; 146: 168-73.
43. Woodward T: History of the commissions on immunization and rickettsial diseases. In: The Armed Forces Epidemiological Board: The History of the Commissions: Textbook of Military Medicine, pp 530-43. Edited by Woodward TE. Washington, DC, Borden Institute, Office of the Surgeon General, Department of the Army, 1994.
44. Strickman D, Sheer T, Salata K, et al: In vitro effectiveness of azithromycin against doxycycline resistant and susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus. Antimicrob Agents Chemother 1995; 39: 2406-10.
45. Strickman D: Drug resistant scrub typhus. In: Proceedings of the 4th International Symposium in Public Health, September 11, 1996, Pusan, Korea, pp 83-92. Pusan, Korea, Institute of Public Health, Kosin University, 1996.
46. Corwin A, Sonderquist R, Suwanabunn N, et al: Scrub typhus and military operations in Indochina. Clin Infect Dis 1999; 29: 940-1.
47. Watt G, Kantipong P, Jongsakul K, et al: Doxycycline and rifampicin for mild scrub-typhus Infections In northern Thailand: a randomised trial. Lancet 2000; 356: 1057-61.
48. Card WI, Walker JM: Scrub-typhus vaccine: field trial in south-east Asia. Lancet 1947; 1: 481-483.
49. Eisenberg GH, Osterman JV: Gamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains. Infect Immun 1979; 26: 131-6.
50. Casleton BG, Salata K, Dasch GA, Strickman DA, Kelly DJ: Recovery and viability of Orientia tsutsugamushi from packed red cells and the danger of acquiring scrub typhus from blood transfusion. Transfusion 1998; 38: 680-9.
51. Belanger KJ, Kelly DJ, Mettille FC, Hanson CV, Lippert LE: Psoralen photochemical inactivation of Orientia tsutsugamushi in platelet concentrates. Transfusion 2000; 40: 1503-7.
52. Mettille FC, Salata KF, Belanger KJ, Castleton BG, Kelly DJ: Reducing the risk of transfusion-transmitted rickettsial disease by WBC filtration, using Orientia tsutsugamushi in a model system. Transfusion 2000; 40: 290-6.
53. Huxsoll DL: Canine ehrlichiosis (tropical canine pancytopenia): a review. Vet Parasitol 1976; 2: 49-60.
54. Rohrbach BW, Harkess JR, Ewing SA, Kudlac J, McKee GL, Istre GR: Epidemiologic and clinical characteristics of persons with serologic evidence of E. canis infection. Am J Public Health 1990; 80: 442-5.
55. Fingerle V, Goodman JL, Johnson RC, Kurtti TJ, Munderloh UG, Wilske B: Human granulocytic ehrlichiosis in southern Germany: Increased seroprevalence in high-risk groups. J Clin Microbiol 1997; 35: 3244-7.
56. Walker DH: Rickettsioses of the spotted fever group around the world. J Dermatol 1989; 16: 169-77.
57. Botros BA, Elmolla MS, Salib AW, Calamaio CA, Dasch GA, Arthur RR: Canine ehrlichiosis in Egypt: sero-epidemiological survey. Onderstepoort J Vet Res 1995; 62: 41-3.
58. Walker JS, Rundquist JD, Taylor R: Clinical and clinicopathological findings in tropical canine pancytopenia. J Am Vet Med Assoc 1970; 157: 43-55.
59. Dawson JE, Anderson BE, Fishbein DB, et al: Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J Clin Microbiol 1991; 29: 2741-5.
60. Warner RD, Jemelka ED, Jessen AE: An outbreak of tick-bite associated illness among military personnel subsequent to a field training exercise. J Am Vet Med Assoc 1996; 209: 78-81.
61. Goddard J: Was Bullis fever actually ehrlichiosis? JAMA 1988; 260: 3006-7.
62. Anigstein L, Anigstein D: A review of the evidence in retrospect for a rickettsial etiology in Bullis fever. Texas Rep Biol Med 1975; 33: 201-11.
63. Davidson DE, Dill GS, Tingpalapong M, et al: Prophylactic and therapeutic use of tetracycline during an epizootic of ehrlichiosis among military dogs. J Am Vet Med Assoc 1978; 172: 697-700.
64. Nyindo MB, Ristic M, Huxsoll DL, Smith AR: Tropical canine pancytopenia: in vitro cultivation of the causative agent, Ehrlichia canis. Am J Vet Res 1971; 32: 1651-8.
65. Cole AI, Ristic M, Lewis GE, Rapmund G: Continuous propagation of Ehrlichia sennetsu in murine macrophage cell cultures. Am J Trop Med Hyg 1985; 34: 774-80.
66. Ristic M, Huxsoll DL, Tachibana N, Rapmund G: Evidence of a serologic relationship between Ehrlichia canis and Rickettsia sennetsu. Am J Trop Med Hyg 1981; 30: 1324-8.
67. Lewis GE, Huxsoll DL, Ristic M, Johnson AJ: Experimentally induced infection of dogs, cats, nonhuman primates with Ehrlichia equi, etiologic agent of equine ehrlichiosis. Am J Vet Res 1975; 121: 245-57.
68. Lewis GE: Equine ehrlichiosis: a comparison between E. equi and other pathogenic species of Ehrlichia. Vet Parasit 1976; 2: 61-74.
69. Sells DM, Hildebrandt PK, Lewis GE, Nyindo MBA, Ristic M: Ultrastructural observations on Ehrlichia equi organisms in equine granulocytes. Infect Immun 1976; 13: 273-80.
70. Brown GW, Shirai A, Jegathesan M, et al: Febrile illness in Malaysia: an analysis of 1,629 hospitalized patients. Am J Trop Med Hyg 1984; 33: 311-5.
71. Ristic M, Huxsoll DL: Ehrlichiae. In: Bergey's Manual of Systematic Bacteriology, pp 704-9. Edited by Krieg NR, Holt JG. Baltimore, MD, Williams & Wilkins, 1984.
72. Rapmund G, Upham RW, Kundin WD, Manikumaran C, Chan TC: Transovarial development of scrub typhus rickettsiae in a colony of vector mites. Trans R Soc Trop Med Hyg 1969; 63: 251-8.
73. Kelly DJ, Lee M, Lewis GE: A light and electron microscopic examination of Ehrlichia sennetsu in cultured human endothelial cells. Jpn J Med Sci Biol 1985; 38: 155-168.
74. Rooney TB, McGue TE, Delahanty KC: A Naval Academy midshipman with ehrlichiosis after summer field exercises in Quantico, VA. Milit Med 2001; 166: 191-3.
75. Petersen LR, Sawyer LA, Fishbein DB, et al: An outbreak of ehrlichiosis in members of an Army Reserve unit exposed to ticks. J Infect Dis 1989; 159: 562-8.
76. Yevich SJ, Sanchez JL, DeFraites RF, et al: Seroepidemiology of infections due to spotted fever group rickettsiae and ehrlichiae species in military personnel exposed in areas where such infections are endemic. J Infect Dis 1995; 171: 1266-73.
77. Hale BR, Tribble DR, Dumler JS, et al: Serosurvey of tick-borne illnesses in U. S. Marines at Quantico, VA. Presented at the American Society of Tropical Medicine and Hygiene 47th Annual Meeting, October 18-22, 1998, San Juan, Puerto Rico.
78. Sanchez JL, Candler WH, Fishbein DB, et al: A cluster of tick-borne infections: association with military training and asymptomatic infections due to Rickettsia rickettsii. Trans R Soc Trop Med Hyg 1992; 86: 321-5.
79. Arguin PM, Singleton J, Rotz LD, et al: An investigation into the possibility of transmission of tick-borne pathogens via blood transfusion. Transfusion 1999; 39: 828.
80. Richards AL, Jiang J, Barker TL: Low prevalence of antibody to human granulocytic ehrlichia (HE) agent found among U.S. military personnel. Presented at the American Society for Rickettsiology-Bartonella Joint Conference on Rickettsia and Bartonella as an Emerging Pathogen Group. August 17-22, 2001, Big Sky, MT.
81. Heppner DG, Wongsrichanalai C, Walsh DS, et al: Human ehrlichiosis in Thailand. Lancet 1997; 350: 7856.
82. Stromdahl EY, Evans SR, O'Brien JJ, Gutierrez AG: Prevalence of infection in ticks submitted to the human tick test kit program of the U.S. Army Center for Health Promotion and Preventive Medicine. J Med Entomol 2001; 38: 67-74.
83. Bernit E, Raoult D: African rickettsia infections. Presse Med 1999; 28: 1428-32.
84. Kelly PJ, Beati L, Mason PR, Matthewman LA, Roux V, Raoult D: Rickettsia africae sp. nov., the etiological agent of African tick bite fever. Int J Syst Bacteriol 1996; 46: 611-614.
85. Jensenius M, Fournier PE, Kelly P, Myrvang B, Raoult D: African tick bite fever. Lancet Infect Dis 2003; 3: 557-64.
86. Kardatzke JT, Neidhardt K, Dzuban DP Sanchez JL, Azad AF: Cluster of tickborne infections at Fort Chaffee, AR: rickettsiae and Borellia burgdorferi in Ixodid ticks. J Med Entomol 1992; 29: 669-72.
87. Paddock CD, Sumner JW, Comer JA, et al: Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. Clin Infect Dis 2004; 38: 805-811.
88. Williams WJ, Radulovic A, Dasch GA, et al: Identification of Rickettsia conorii infection by polymerase chain reaction in a soldier returning from Somalia. Clin Infect Dis 1994; 19: 93-9.
89. Sirisanthana T, Pinyopornpanit V, Sirisanthana V, Strickman D, Kelly DJ, Dasch GA: First cases of spotted fever group rickettsiosis in Thailand. Am J Trop Med Hyg 1994; 50: 682-6.
90. Smoak BL, McClain JB, Brundage JF, et al: An outbreak of spotted fever rickettsiosis in U.S. Army troops deployed to Botswana. Emerg Infect Dis 1996; 2: 217-21.
91. Thornton SA, Olson PE, Medina MJ, et al: Confirmation of African tick bite fever agent in the Caribbean: another "Old World" disease arrives on our shores. Presented at the 41st Annual Meeting of the Infectious Diseases Society of America, October 9-12, 2003, San Diego, CA.
92. Woodward TE, Pedersen CE, Oster CN, Bagley LR, Romberger J, Snyder MJ: Prompt confirmation of Rocky Mountain spotted fever: identification of rickettsiae in skin tissues. J Infect Dis 1976; 134: 297-301.
93. Kelly DJ, Wong PW, Gan E, Lewis GE: Comparative evaluation of the indirect immunoperoxidase test for the serodiagnosis of rickettsial disease. Am J Trop Med Hyg 1988; 38: 400-6.
94. Kelly DJ, Wong PW, Gan E, Chye TC, Cowan D, Lewis GE: Multi-laboratory evaluation of a scrub typhus diagnostic kit. Am J Trop Med Hyg 1990; 43: 301-7.
95. Broadhurst LE, Kelly DJ, Chan CT, et al: Laboratory evaluation of a dot-blot enzyme immunoassay for serologic confirmation of illness due to Rickettsia conorii. Am J Trop Med Hyg 1998; 58: 786-9.
96. Azad AF, Webb L, Carl M, Dasch GA: Detection in arthropod vectors by DNA amplification using the polymerase chain reaction. Ann NY Acad Sci 1990; 590: 557-63.
97. Raoult D, Dasch GA: Immunoblot cross-reactions among Rickettsia, Proteus spp. and Legionella spp in patients with Mediterranean spotted fever. FEMS Immunol Med Microbiol 1995; 11: 13-8.
98. Eremeeva M, Dasch GA, Silverman DJ: Quantitative analysis of variations in the injury of endothelial cells elicited by 11 isolates of Rickettsia rickettsii. Clin Diagn Lab Immunol 2001; 8: 788-96.
99. Radulovic S, Higgins JA, Jaworski DC, Dasch GA, Azad AF: Isolation, cultivation, and partial characterization of the ELB agent associated with cat fleas. Infect Immun 1995; 63: 4826-9.
100. Eremeeva MA, Ching WM, Wu Y, Silverman DJ, Dasch GA: Western blotting analysis of heat shock proteins of Rickettsiales and other eubacteria. FEMS Microbiol Lett 1998; 167: 229-37.
101. Cianciotto NP, O'Connell W, Dasch GA, Mallavia LP: Detection of mip-like sequences and Mip-related proteins within the family Rickettsiaceae. Curr Microbiol 1995; 30: 149-53.
102. Dasch GA, Jackson LM: Genetic analysis of isolates of the spotted fever group of Rickettsiae belonging to the R. conorii complex. Ann NY Acad Sci 1998; 849: 11-20.
103. Shirai A, Bozeman FM, Humphries JW, Elisberg BL, Faber JE: Experimental infection of the cotton rat Sigmodon hispidus with Rickettsia rickettsii. J Bacteriol 1967; 94: 1334-9.
104. Smadel JE, Woodward TE, Ley HL, et al: Chloromycetin in the treatment of scrub typhus. Science 1948; 108: 160-1.
105. Bozeman FM, Elisberg BL: Serological diagnosis of scrub typhus by indirect immunofluorescence. Proc Soc Exp Biol Med 1963; 112: 568-73.
106. Rapmund G: Rickettsial diseases of the Far East: new perspectives. J Infect Dis 1984; 149: 330-8.
107. Olson JG, Bourgeois AL, Fang RC, Coolbaugh JC, Dennis DT: Prevention of scrub typhus: prophylactic administration of doxycycline in a randomized double blind trial. Am J Trop Med Hyg 1980; 29: 989-97.
108. Twartz JC, Shirai A, Selvaraju G, Saunders JP, Huxsoll DL, Groves MG: Doxycycline prophylaxis for human scrub typhus. J Infect Dis 1982; 146: 811-8.
109. Stover CK, Marana DP, Dasch GA, Oaks EV: Molecular cloning and sequence analysis of the Sta58 major antigen gene of Rickettsia tsutsugamushi: sequence homology and antigenic comparison of Sta58 to the 60-kilodalton family of stress proteins. Infect Immun 1990; 58: 1360-8.
110. Carl M, Tibbs CW, Dobson ME, Paparello M, Dasch GA: Diagnosis of acute typhus infection using the polymerase chain reaction. J Infect Dis 1990; 161: 791-3.
111. Kelly DJ, Marana DP, Stover CK, Oaks EV, Carl M: Detection of Rickettsia tsutsugamushi by gene amplification using polymerase chain reaction techniques. Ann NY Acad Sci 1990; 590: 584-71.
112. Ching W-M, Rowland D, Zhang Z, et al: Early diagnosis of scrub typhus with a rapid flow assay using recombinant major outer membrane protein antigen (r56) of Orienta tsutsugamushi. Clin Diagn Lab Immunol 2001; 8: 409-14.
113. Jiang J, Chan TC, Temenak JJ, Dasch GA, Ching W, Richards AL: Development of a quantitative real-time PCR assay specific for Orientia tsutsugamushi. Am J Trop Med Hyg 2004; 70: 351-6.
114. Hong G, Chuang YE, Zho S, et al: Comparative genomics of Rickettsia prowazekii Madrid E and Breinl strains. J Bacteriol 2004; 186: 556-65.