The quantitative analysis of uranium isotopes in the urine of the civilian population of Eastern Afghanistan after operation enduring freedom

Military Medicine

Volumn 170, Issue 4, 2005, Pages 277-284

  Durakovic, Asaf ^a  

^a Uranium Medical Research Centre   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; URANIUM; URANIUM 234; URANIUM 235; URANIUM 236; URANIUM 238;

AFGHANISTAN; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DUST EXPOSURE; FATIGUE; FEVER; HEADACHE; HUMAN; IONIZATION; ISOTOPE ANALYSIS; MALE; MASS SPECTROMETRY; MUSCULOSKELETAL DISEASE; NEUROLOGIC DISEASE; QUANTITATIVE ANALYSIS; RADIOACTIVE CONTAMINATION; RESPIRATORY FUNCTION DISORDER; URINE LEVEL;

EID: 17444417445     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.7205/MILMED.170.4.277     Document Type: Article

References (78)

1. Miller AC, Stewart M, Brooks K, Shi L, Page N: Depleted uranium catalyzes oxidative DNA damage: absence of significant α-particle decay. J Inorg Biochem 2002; 91: 246-52.
2. Miller AC, Brooks K, Stewart M, et al: Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation. J Environ Radioact 2003; 64: 247-59.
3. Arfsten DP, Still KR, Ritchie GD: A review of the effects of uranium and depleted uranium exposure on reproduction and fetal development. Toxicol Ind Health 2001; 17: 180-91.
4. Durakovic A, Dietz L, Zimmerman I: Differential decay analysis of the α-dose of depleted uranium and the neoplastic risk in the lungs of Gulf War veterans. J Nucl Med 2003; Suppl: 326.
5. Bleise A, Dansi PR, Burkart W: Properties, use and health effects of depleted uranium (DM): a general overview. J Environ Radioact 2003; 64: 93-112.
6. Durakovic A, Dietz L, Horan P, Zimmerman I: Estimate of time zero lung burden of depleted uranium in Gulf War veterans by the 24-hour urinary excretion and experimental decay analysis. Milit Med 2003; 168: 600-5.
7. Durante M, Pugliese M: Depleted uranium residual radiological risk assessment for Kosovo sites. J Environ Radioact 2003; 64: 237-45.
8. Giannardi C, Dominici D: Military use of depleted uranium: assessment of prolonged population exposure. J Environ Radioact 2003; 64: 227-36.
9. Salbu B, Janssen K, Lindo C, Proost K, Danesi PR: Oxidation states of uranium in DU particles from Kosovo. J Environ Radioact 2003; 64: 167-73.
10. Bolton JP, Foster CR: Battlefield use of depleted uranium and the health of veterans. J R Army Med Corps 2002; 148: 221-9.
11. Diaz Sylvester PL, Lopez R, Ubrios AM, Cabrini RL: Exposure to subcutaneously implanted uranium dioxide impairs bone formation. Arch Environ Health 2002; 57: 320-35.
12. Shawky S, Amer HA, Hussein MI, el-Mahdy Z, Mustafa M: Uranium bioassay and radioactive dust measurements at some uranium processing sites in Egypt: health effects. J Environ Monit 2002; 4: 588-91.
13. Roemer HC, Golka K, Schulze H, Loehlein D: Two extrapulmonary neoplasms in a uranium miner. J R Soc Med 2002; 95: 302.
14. Schroeder C, Friedrich K, Butz M, Koppisch D, Otten H: Uranium mining in Germany: incidence of occupational diseases 1946-1999. Int Arch Occup Environ Health 2002; 75: 235-42.
15. Kurttio P, Auvinen A, Salvonen L, et al: Renal effects of uranium in drinking water. Environ Health Perspect 2002; 110: 337-42.
16. Kryscio A, Ulrich Muller WU, Wojcik A, Kotschy N, Grobelny S, Streffer C: A cytogenetic analysis of the long-term effect of uranium mining on peripheral lymphocytes using the micronucleus-centromere assay. Int J Radiat Biol 2001; 77: 1087-93.
17. Tretri'iakov SV, Shpagina CS, Kuznetsova GV, Liulina NV, Musatova AS: Functional cardiovascular status in patients with high blood pressure and coronary heart disease in a remote period of uranium intoxication [in Russian]. Med Tr Prom Ekol 2002; 2: 6-11.
18. Ellender M, Harrison JD, Pottinger H, Thomas JM: Induction of osteosarcoma and acute myeloid leukemia in CBA/H mice by the α-emitting nuclides, uranium-233, plutonium-239 and americium-241. Int J Radiat Biol 2001; 77: 41-52.
19. Schiermeir Q: Skepticism greets claims that uranium shells cause leukemia. Nature 2001; 409: 121.
20. Mele A, Mandelli F: Research on depleted uranium must continue [in Italian]. Epidemiol Prev 2001; 25: 158.
21. Lagercrantz B: Depleted uranium a cancer risk that disappeared: leukemia alarm regarding Balkan veterans came to nothing [in Swedish]. Lakartidningen 2003; 100: 219-21.
22. Aitken M: Gulf War leaves legacy of cancer. BMJ 1999; 319: 401.
23. Bithell JF, Draper GJ: Uranium-235 and childhood leukemia around Greenhau Concord Airfield. J Radiol Prot 1999; 19: 253-9.
24. Ritz B: Radiation exposure and cancer mortality in uranium processing workers. Epidemiology 1999; 10: 531-8.
25. Stram DO, Langholz B, Hubercman M, Thomas DC: Correcting for exposure measurement error in reanalysis of lung cancer mortality for the Colorado Plateau Uranium Miners cohort. Health Phys 1999; 77: 265-75.
26. Suzuki T: Zur Morphologie and Nierensekretion unter physiologyischen and pathologischen Bedingungen. Jena: Gustav Fislier; 1912; cited in Yuille CL: In: Handbook of Experimental Pathology, pp 167-96. Edited by Hodge HC, Standard JN, Hursh JB. Heidelberg, Germany, Springer-Verlag. 1973.
27. Suzuki T: Zur Morphologie and Nierensekretion unter physiologyischen and pathologischen Bedingungen. Jena: Gustav Fislier; 1912; cited in Yuille CL: In: Handbook of Experimental Pathology, pp 167-96. Edited by Hodge HC, Standard JN, Hursh JB. Heidelberg, Germany, Springer-Verlag. 1973.
28. Zamora ML, Tracy BL, Zielinski JM, Meyerhof DP, Moss MA: Chronic ingestion of uranium in drinking water: a study of kidney bioeffects in humans. Toxicol Sci 1998; 43: 68-77.
29. Pellmar TC, Keyser DO, Emery C, Hogan JB: Electrophysiological changes in hippocampal slices isolated from rats embedded with depleted uranium fragments. Neurotoxicology 1999; 20: 785-92.
30. Chittenden RH: The physiological action of uranium salts. Ther Gaz 1888; 12: 698-9.
31. Barbante C, Van De Velde K, Cozzi G, et al: Post World War II, uranium changes in dated Mont Blanc ice and snow. Environ Sci Technol 2001; 35: 4026-30.
32. Peterson MJ, Smith JG, Southworth GR, Ryon MG, Eddlemon GK: Trace element contamination in benthic marcoinvertebrates from a small stream near a uranium mill-tailings site. Environ Monit Assess 2002; 74: 193-208.
33. Papp Z, Desso Z, Daroczy S: Significant radioactive contamination of soil around a coal-fired thermal power plant. J Environ Radioact 2002; 59: 191-205.
34. Yamamato M, Kawabata Y, Murata Y, Komura K: Variation of uranium isotopic composition in soil within JCO grounds from the 30 September 1999 criticality accident at JCO Tokai-mura, Japan. Health Phys 2002; 83: 197-203.
35. Uyttenhove J, Lemmens M, Zizi M: Depleted uranium in Kosovo: results of a survey by γ-spectrometry on soil samples. Health Phys 2002; 38: 543-8.
36. Papastefanou C: Depleted uranium in military conflicts and the impact on the environment. Health Phys 2002; 83: 280-2.
37. Bellis D, Ma R, Bramall N, McLeod CW, Chapman N, Satake K: Airborne uranium contamination as revealed through elemental and isotopic analysis of tree bark. Environ Pollut 2001; 114: 383-7.
38. 238U in tree bark. J Environ Monit 2001; 3: 198-201.
39. Koch-Steindl H, Prohl G: Considerations on the behavior of long lived radionuclides in the soil. Radiat Environ Biophys 2001; 40: 93-104.
40. 238U contamination on some road surfaces in Taoyuan, Taiwan. Health Phys 2001; 80: 602-4.
41. Axelson O, Fredrikson M, Akerblom G, Hardell L: Leukemia in childhood and adolescence and exposure to ionizing radiation in homes built from uranium-containing alum shale concrete. Epidemiology 2002; 13: 146-50.
42. Cantaluppi C, Degetto S: Civilian and military uses of depleted uranium: environmental and health problems. Ann Clim 2000; 90: 665-76.
43. Elless MP, Armstrong AQ, Lee SY: Characterization and solubility measurements of uranium-contaminated soils to support risk assessment. Health Phys 1997; 72: 716-26.
44. Suzuki Y, Kelly SD, Kemner KM, Banfield JF: Namometre-size products of uranium bioreduction. Nature 2002; 419: 134.
45. Finerau K, Housewright ME, Looley DR: Multiple influences of nitrate on uranium solubility during bioremediation of uranium-contaminated subsurface sediments. Environ Microbiol 2002; 4: 510-6.
46. Senko JM, Istok JD, Suflita JM, Krumholz LR: In situ evidence for uranium immobilization and remobilization. Environ Sci Technol 2002; 36: 1491-6.
47. Franke K, Rossler D, Gottschalch U, Kupsch H: Mobilization and retardation of uranium DOC species at three mine piles in Schlema/Alberoda, Saxony, Germany. Isot Environ Health Stud 2000; 36: 223-39.
48. Hamby DM, Tynybekov AK: Uranium, thorium and potassium in soils along the shore of Lake Issyk-Kyol in the Kyrghyz Republic. Environ Monit Assess 2002; 73: 101-8.
49. Le Conte C: Rescue des experiences sur l'zofate d'uranium. C R Soc Biol Paris 1853; 5: 171-3.
50. Bassett SH, Frenkel A, Cedars N, Vau Alstine H, Waterhouse C, Cusson K: The Excretion of Hexavalent Uranium Following Intravenous Administration. II. Studies on Human Subjects. USAEC Report UR-37, 1948; cited in ATSDR (Agency for Toxic Substances and Disease Registry) Toxicology Profile for Uranium. Atlanta, GA, ATSDR, 1999.
51. Bassett SH, Frenkel A, Cedars N, Vau Alstine H, Waterhouse C, Cusson K: The Excretion of Hexavalent Uranium Following Intravenous Administration. II. Studies on Human Subjects. USAEC Report UR-37, 1948; cited in ATSDR (Agency for Toxic Substances and Disease Registry) Toxicology Profile for Uranium. Atlanta, GA, ATSDR, 1999.
52. Luessenhop AJ, Gallimore JC, Sweet WH, Struxness EG, Robinson J: The toxicity in man of hexavalent uranium following intravenous administration. Am J Radiol 1958; 79: 83-100.
53. Bernard SR, Muir J, Royster GW Jr: The distribution and excretion of uranium in man. Proc Health Phys Soc 1956; 33-48.
54. Hursch JB, Newman WG, Toribara T, Wilson H, Waterhouse C: Oral ingestion of uranium by man. Health Phys 1969; 17: 619-21.
55. Fish BR: Inhalation of Uranium Aerosols by Mouse, Rat, Dog and Man. In: Inhaled Particles and Vapours 1, pp 209-18. London, United Kingdom, Pergamon Press, 1961.
56. 8 dust to toxicity following inhalation by animals. Arch Ind Hyg 1956; 11: 11-6.
57. Morrow PE, Gibb FR, Leach LJ: The clearance of uranium dioxide dust from the lungs following single and multiple inhalation exposures. Health Phys 1969; 12: 1217-23.
58. Nielsen SW, Horava A: Primary pulmonary neoplasms of the dog: report of sixteen cases. Am J Vet Res 1960; 21: 813-30.
59. Hursh J, Spoor NL: Data on man. In: Uranium, Plutonium. Transplutonic Elements, pp 197-239. Edited by Hodge HC, Stannard JN, Hursh JB. Heidelberg, Germany, Springer-Verlag, 1973.
60. Shawky S, Awer HA, Hussein MI, El-Mahdy Z, Mustafa M: Uranium bioassay and radioactive dust measurements at some uranium processing sites in Egypt: health effects. J Environ Monit 2002; 4: 588-91.
61. Krystek P, Ritsema R: Determination of uranium in urine: measurement of isotope ratios and quantification by use of inductively coupled plasma mass spectrometry. Anal Bioanal Chem 2002; 374: 226-9.
62. Durakovic A, Parrish R, Gerdes A, Zimmerman I: The quantitative analysis of uranium isotopes in the urine of civilians after Operation Enduring Freedom in Jalalabad, Afghanistan. Presented at the Health Physic Annual Meeting, San Diego, CA, June 20-24, 2003.
63. Hakonson-Hayes AC, Fresquez PR, Whicker FW: Assessing potential risks from exposure to natural uranium in well water. J Environ Radioact 2002; 59: 29-40.
64. Pyle GG, Swanson SM, Lehmkhl DM: Toxicity of uranium mine-receiving waters to caged fathead minnows. Ecotoxicol Environ Saf 2001; 98: 202-14.
65. Gilliand FD, Hunt WC, Pardilla M, Key CR: Uranium mining and lung cancer among men in New Mexico and Arizona, 1969-1973. J Occup Environ Med 2000; 92: 278-83.
66. Stram DO, Langholz B, Huberman M, Thomas DC: Correcting for exposure measurement error in reanalysis of lung cancer mortality for the Colorado Plateau Uranium Miners cohort. Health Phys 1999; 77: 265-75.
67. Karpas Z, Corbor A, Elish E, et al: Uranium in urine: normalization to creatinine. Health Phys 1998; 74: 86-90.
68. Karpas Z, Halicz L, Roiz J, et al: Inductively coupled plasma mass spectrometry as a simple, rapid, and inexpensive method for determination of uranium in mine and fresh water. Health Phys 1996; 71: 879-85.
69. Danesi PR, Bleise A, Burkart W, et al: Isotopic composition and origin of uranium and plutonium in selected soil samples collected in Kosovo. J Environ Radioact 2003; 64: 121-31.
70. Papastefamou C: Depleted uranium in military conflicts and the impact on the environment. Health Phys 2002; 83: 280-2.
71. Sansone U, Stellato L, Jia G, et al: Levels of uranium in Kosovo soils. Radiat Protect Dosimetry 2001; 97: 317-30.
72. Durante M, Pugliese M: Estimates of radiological risk from depleted uranium weapons in war. Health Phys 2002; 82: 14-20.
73. Domingo JL: Chemical toxicity of uranium. Toxicol Ecotoxicol News 1995; 2: 853-5.
74. Hu Q, Zhu S: Induction of chromosomal aberrations in male mouse sperm cells by uranyl fluoride containing enriched uranium. Mutat Res 1990; 244: 209-14.
75. Harrison JD, Muirhead CR: Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation. Int J Radiat Biol 2003; 79: 1-13.
76. Elless MP, Armstrong AQ, Lee SY: Characterization and solubility measurements of uranium-contaminated soils to support risk assessment. Health Phys 1997; 72: 716-26.
77. Suzuki Y, Kelly SD, Kemmer KM, Banfield JF: Nanometre-size products of uranium bioreduction. Nature 2002; 419: 134.
78. Finneran KT, Housewright ME, Lowley DR: Multiple influences of nitrate on uranium solubility during bioremediation of uranium-contaminated subsurface sediments. Environ Microbiol 2002; 4: 510-6.