Dexamethasone impairs muscle energetics, studied by 31P NMR, in rats

Diabetologia

Volumn 48, Issue 2, 2005, Pages 328-335

  Dumas, J F ^a   Bielicki, G ^b   Renou, J P ^b   Roussel, D ^a   Ducluzeau, P H ^a   Malthiery Y ^a   Simard, G ^a   Ritz, P ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b Site de Theix   (France)

Author keywords

ATP; Food restriction; Glucocorticoid; Oxidative phosphorylation; Phosphocreatine

Indexed keywords

ADENOSINE DIPHOSPHATE; CREATINE PHOSPHATE; DEXAMETHASONE; FATTY ACID; INSULIN;

ANIMAL MODEL; ARTICLE; DIET RESTRICTION; ENERGY EXPENDITURE; ENERGY TRANSFER; FATTY ACID BLOOD LEVEL; GASTROCNEMIUS MUSCLE; INSULIN BLOOD LEVEL; METABOLIC DISORDER; MUSCLE METABOLISM; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

3-HYDROXYBUTYRIC ACID; ADENINE NUCLEOTIDES; ANIMALS; BODY WEIGHT; DEXAMETHASONE; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; HYDROGEN-ION CONCENTRATION; INSULIN; LEPTIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHOSPHATES; PHOSPHOCREATINE; PHOSPHORUS RADIOISOTOPES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 17444406977     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1631-0     Document Type: Article

References (46)

1. Stanley WC, Lopaschuk GD, McCormack JG (1997) Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc Res 34:25-33
2. Scheuermann-Freestone M, Madsen PL, Manners D et al (2003) Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 107:3040-3046
3. Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS (2003) Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc Natl Acad Sci USA 100:7996-8001
4. Perez-Carreras M, Del Hoyo P, Martin MA et al (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38:999-1007
5. Petersen KF, Befroy D, Dufour S et al (2003) Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300:1140-1142
6. Rizza RA, Mandarino LJ, Gerich JE (1982) Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 54:131-138
7. Willi SM, Kennedy A, Wallace P, Ganaway E, Rogers NL, Garvey WT (2002) Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes 51:2895-2902
8. Guillaume-Gentil C, Assimacopoulos-Jeannet F, Jeanrenaud B (1993) Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats. Diabetologia 36:899-906
9. Woodward CJ, Emery PW (1989) Energy balance in rats given chronic hormone treatment. 2. Effects of corticosterone. Br J Nutr 61:445-452
10. Tataranni PA, Larson DE, Snitker S, Young JB, Flatt JP, Ravussin E (1996) Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol 271:E317-E325
11. Brillon DJ, Zheng B, Campbell RG, Matthews DE (1995) Effect of cortisol on energy expenditure and amino acid metabolism in humans. Am J Physiol 268:E501-E513
12. Dumas JF, Simard G, Roussel D, Douay O, Foussard F, Malthiery Y, Ritz P (2003) Mitochondrial energy metabolism in a model of undernutrition induced by dexamethasone. Br J Nutr 90:969-977
13. Roussel D, Dumas JF, Augeraud A et al (2003) Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett 541:75-79
14. Pignatelli D, Magalhaes MM, Magalhaes MC (1998) Direct effects of stress on adrenocortical function. Horm Metab Res 30:464-474
15. Mitsuo T, Rounds J, Prechek D, Wilmore DW, Jacobs DO (1996) Glucocorticoid receptor antagonism by mifepristone alters phosphocreatine breakdown during sepsis. Arch Surg 131:1179-1185
16. Minet-Quinard R, Moinard C, Walrand S et al (2000) Induction of a catabolic state in rats by dexamethasone: dose or time dependency? JPEN J Parenter Enteral Nutr 24:30-36
17. Caldefie-Chezet F, Moinard C, Minet-Quinard R, Gachon F, Cynober L, Vasson M (2001) Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats. Metabolism 50:1054-1058
18. Alger JR, Shulman RG (1984) NMR studies of enzymatic rates in vitro and in vivo by magnetization transfer. Q Rev Biophys 17:83-124
19. Ravalec X, Le Tallec N, Carre F, de Certaines JD, Le Rumeur E (1996) Improvement of muscular oxidative capacity by training is associated with slight acidosis and ATP depletion in exercising muscles. Muscle Nerve 19:355-361
20. 31P-NMR. Biochim Biophys Acta 1133:115-120
21. 31P magnetic resonance spectroscopy of (human) skeletal muscle. Proc Nutr Soc 58:861-870
22. eq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J Biol Chem 254:6528-6537
23. Gadian DG (1995) NMR and its applications to living systems, 2nd edn. Oxford Science Publications, Oxford
24. 31P NMR surface coil studies in brain, heart, and skeletal muscle of the living rat. Biochemistry 26:6083-6090
25. Dobbins RL, Malloy CR (2003) Measuring in-vivo metabolism using nuclear magnetic resonance. Curr Opin Clin Nutr Metab Care 6:501-509
26. Dawson MJ, Gadian DG, Wilkie DR (1980) Mechanical relaxation rate and metabolism studied in fatiguing muscle by phosphorus nuclear magnetic resonance. J Physiol 299:465-484
27. Kushmerick MJ, Moerland TS, Wiseman RW (1992) Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi. Proc Natl Acad Sci USA 89:7521-7525
28. Gardiner PF, Montanaro G, Simpson DR, Edgerton VR (1980) Effects of glucocorticoid treatment and food restriction on rat hindlimb muscles. Am J Physiol 238:E124-E130
29. Lewis MI, Monn SA, Sieck GC (1992) Effect of corticosteroids on diaphragm fatigue, SDH activity, and muscle fiber size. J Appl Physiol 72:293-301
30. Prezant DJ, Karwa ML, Richner B, Maggiore D, Gentry EI, Cahill J (1997) Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function. J Appl Physiol 82:125-133
31. Prezant DJ, Karwa ML, Richner B et al (1998) Short-term vs. long-term dexamethasone treatment: effects on rat diaphragm structure and function. Lung 176:267-280
32. Wilcox PG, Hards JM, Bockhold K, Bressler B, Pardy RL (1989) Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscle. Am J Respir Cell Mol Biol 1:191-199
33. Kushmerick MJ, Meyer RA (1985) Chemical changes in rat leg muscle by phosphorus nuclear magnetic resonance. Am J Physiol 248:C542-C549
34. Meyer RA, Brown TR, Kushmerick MJ (1985) Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle. Am J Physiol 248:C279-C287
35. Pichard C, Vaughan C, Struk R, Armstrong RL, Jeejeebhoy KN (1988) Effect of dietary manipulations (fasting, hypocaloric feeding, and subsequent refeeding) on rat muscle energetics as assessed by nuclear magnetic resonance spectroscopy. J Clin Invest 82:895-901
36. Thompson A, Damyanovich A, Madapallimattam A, Mikalus D, Allard J, Jeejeebhoy KN (1998) 31P-nuclear magnetic resonance studies of bioenergetic changes in skeletal muscle in malnourished human adults. Am J Clin Nutr 67:39-43
37. Gupta RK, Mittal RD, Agarwal KN, Agarwal DK (1994) Muscular sufficiency, serum protein, enzymes and bioenergetic studies (31-phosphorus magnetic resonance spectroscopy) in chronic malnutrition. Acta Paediatr 83:327-331
38. Argov Z, Chance B (1991) Phosphorus magnetic resonance spectroscopy in nutritional research. Annu Rev Nutr 11:449-464
39. Dimitriadis G, Leighton B, Parry-Billings M et al (1997) Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J 321:707-712
40. Leighton B, Challiss RA, Lozeman FJ, Newsholme EA (1987) Effects of dexamethasone treatment on insulin-stimulated rates of glycolysis and glycogen synthesis in isolated incubated skeletal muscles of the rat. Biochem J 246:551-554
41. Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217:383-393
42. Martens ME, Peterson PL, Lee CP (1991) In vitro effects of glucocorticoid on mitochondrial energy metabolism. Biochim Biophys Acta 1058:152-160
43. Venkatesan N, Davidson MB, Hutchinson A (1987) Possible role for the glucose-fatty acid cycle in dexamethasone-induced insulin antagonism in rats. Metabolism 36:883-891
44. Horska A, Brant LJ, Ingram DK, Hansford RG, Roth GS, Spencer RG (1999) Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats. Am J Physiol 276:E766-E773
45. Ramsey JJ, Harper ME, Weindruch R (2000) Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med 29:946-968
46. Koerts-de Lang E, Schols AM, Rooyackers OE, Gayan-Ramirez G, Decramer M, Wouters EF (2000) Different effects of corticosteroid-induced muscle wasting compared with under-nutrition on rat diaphragm energy metabolism. Eur J Appl Physiol 82:493-498