In vitro and in vivo study of octacosanol metabolism

Archives of Medical Research

Volumn 36, Issue 2, 2005, Pages 113-119

  Menéndez, Roberto ^a   Marrero, David ^a   Más, Rosa ^a   Fernández, Ivon ^a   González, Luis ^a   González, Rosa Maria ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

Chain shortened fatty acids; Octacosanoic acid; Octacosanol metabolism; Policosanol

Indexed keywords

LIPID; OCTACOSANOL; POLICOSANOL; SATURATED FATTY ACID; SHORT CHAIN FATTY ACID;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FIBROBLAST CULTURE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MACACA; MALE; MASS SPECTROMETRY; NONHUMAN; RADIATION DETECTION; RAT; THIN LAYER CHROMATOGRAPHY;

EID: 17444397048     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2004.12.006     Document Type: Article

References (35)

1. Laguna A, Magraner J, Carbajal D, Arruzazabala ML, Más R, García M. A mixture of higher primary aliphatic alcohols, its obtention from sugar cane wax and its pharmacological uses. U.S. Patent 5663156, 1997.
2. M.L. Arruzazabala, D. Carbajal, R. Más, G. Castaño, V. Sotolongo, and R. Mesa Efecto del ateromixol (PPG) sobre los niveles de colesterol séricos en perros beagle Rev CNIC Cien Biol 22 1991 60 63
3. M.L. Arruzazabala, D. Carbajal, R. Más, V. Molina, S. Valdés, and A. Laguna Cholesterol-lowering effects of policosanol in rabbits Biol Res 27 1994 205 208
4. R. Menéndez, M.L. Arruzazabala, A. del Río, A.M. Amor, R.M. González, D. Carbajal, V. Fraga, V. Molina, and J. Illnait Cholesterol-lowering effect of policosanol on rabbits with hypercolesterolemia induced by a wheat starch-casein diet Br J Nutr 77 1997 923 932
5. J. Hernández, J. Illnait, R. Más, G. Castaño, J.C. Fernández, M. González, N. Cordoví, and L. Fernández Effects of policosanol on serum lipids and lipoproteins in healthy volunteers Curr Ther Res 51 1993 568 575
6. E. Aneiros, R. Mas, B. Calderón, J. Illnait, and L. Fernández Effects of policosanol in lowering cholesterol level in patients with type II hypercholesterolemia Curr Ther Res 56 1995 176 181
7. M. Canetti, M.S. Morera, R. Más, J. Illnait, L. Fernández, and J.C. Fernández One-year study on the effect of policosanol (5 mg-twice-a day) on lipid profile in patients with type II hypercholesterolemia Adv Ther 12 1995 245 251
8. R. Más, G. Castaño, J. Illnait, L. Fernández, J.C. Fernández, C. Alemán, V. Pontigas, and M. Lescay Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors Clin Pharmacol Ther 65 1998 439 447
9. G. Castaño, R. Más, J.C. Fernández, L.E. López, and L. Fernández A long-term open study of the efficacy and tolerability of policosanol in patients with high global coronary risk Curr Ther Res 60 1999 379 391
10. N. Crespo, J. Illnait, R. Más, L. Fernández, J. Fernández, and G. Castano Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hipercolesterolemia and non insulin-dependent diabetes mellitus Int J Clin Pharmacol Res XIX 1999 105 116
11. G. Castaño, R. Más, L. Fernández, J.C. Fernández, J. Illnait, L.E. López, and E. Alvarez Effects of policosanol on postmenopausal women with type II hypercholesterolemia Gynecol Endocrinol 13 2000 1 9
12. G. Castaño, R. Más, J.C. Fernández, E. Alvarez, and M. Lescay Efficacy and tolerability of policosanol compared with lovastatin in patients with type II hypercholesterolemia and concomitant coronary risk factors Curr Ther Res 61 2000 137 146
13. R. Mas, G. Castano, L. Fernández, J. Illnait, J.C. Fernández, and E. Alvarez Effects of policosanol in older hypercholesterolemic patients with coronary disease Clin Drug Invest 21 2001 485 497
14. G. Castano, Mas, J.C. Fernandez, J. Illnait, L. Fernandez, and E. Alvarez Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk J Gerentol Med Sci 56 2001 M186 M192
15. G. Castano, R. Más, L. Fernández, R. Gámez, and J. Illnait Effects of policosanol and lovastatin in patients with intermittent claudication: a double blind comparative pilot study Angiology 53 2002 231 239
16. G. Castano, R. Mas, L. Fernandez, J. Illnait, M. Mesa, E. Alvarez, and M. Lescay Comparison of the efficacy and tolerability of policosanol and atorvastatin in elderly patients with type II hypercholesterolemia Drug Aging 20 2003 153 163
17. M.L. Arruzazabala, D. Carbajal, R. Más, M. Garía, and V. Fraga Effects of policosanol in platelet aggregation in rats Thromb Res 69 1992 321 327
18. M.L. Arruzazabala, S. Valdés, R. Más, L. Fernández, and D. Carbajal Effects of policosanol successive dose increases in platelet aggregation in healthy volunteers Pharmacol Res 34 1996 181 195
19. M.L. Arruzazabala, V. Molina, R. Mas, L. Fernández, D. Carbajal, S. Valdes, and G. Castano Antiplatelet effect of policosanol (20 and 40 mg/day) in healthy volunteers and dyslipidemic patients Clin Exp Pharmacol Physiol 29 2002 891 897
20. V. Fraga, R. Menéndez, A.M. Amor, R.M. González, S. Jiménez, and R. Más Effects of policosanol on in vitro and in vivo rat microsomal lipid peroxidation Arch Med Res 28 1997 355 360
21. R. Menendez, V. Fraga, A.M. Amor, R.M. González, and R. Más Oral administration of policosanol inhibits in vitro copper-induced rat lipoprotein lipid peroxidation Physiol Behav 67 1997 1 7
22. R. Menéndez, R. Más, A.M. Amor, R.M. González, J.C. Fernández, I. Rodeiro, M. Zayas, and S. Jiménez Effects of policosanol treatment on the susceptibility of low-density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro Br J Clin Pharmacol 20 2000 255 262
23. N. Pérez-Souto, L. González, J. Magraner, L. González, C.M. Mederos, J.L. Reyes, and O. Torres Administración intravenosa de ateromixol (PPG) en perros beagle, cerdos y ratas. Determinación de niveles plasmáticos de 1-octacosanol Rev CENIC Cien Biol 22 1991 15 18
24. R. Más Policosanol. Drugs of the Future 25 2000 569 586
25. Y. Kabir, and S. Kimura Biodistribution and metabolism of orally administered octacosanol to rats Ann Nutr Metab 37 1993 33 38
26. 14C)- octacosanol in liver and muscle of rats after serial administration Ann Nutr Metab 39 1995 279 284
27. Y. Kabir, and S. Kimura Distribution of radioactive octacosanol in response to exercise in rats Die Nahrung 4 1994 373 377
28. R.J.A. Wanders, P. Vreken, S. Ferdinandusse, G.A. Jansen, H.R. Waterham, C.W.T. van Roermund, and G.E. van Grunsven Peroxisomal fatty acid α- and β-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases Biochem Soc Trans 29 2001 250 267
29. P.B. Lazarow The role of peroxisomes in mammalian cellular metabolism J Inherit Metab 10 1987 11 22
30. H. Osmunden, J. Bremer, and J.I. Perdersen Metabolic aspects of peroxisomal β-oxidation Biochem Biophys Acta 1085 1991 141 158
31. L. Vega, L. Ducat, and L. García Marcaje del 1-octacosanol con tritio Nucleus 13 1993 12 16
32. E. Evans Tritium and its Compounds 1974 Butterworths London
33. G.L. Mills, P.A. Lane, and P.K. Weech A guidebook to lipoprotein technique R.H. Burden P.H. Van Knippenberg Laboratory techniques in biochemistry and molecular biology 1984 North-Holland-Elsevier Amsterdam 20 89
34. D. Marrero, and L. González Trace determination of octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography J Chromatogr B 762 2002 43 49
35. D.R. Tocher, M.J. Leaver, and P.A. Hodgson Recent advances in the biochemistry and molecular biology of fatty acyl desaturases Prog Lipid Res 37 1998 73 117