Relaxant effect of Cuminum cyminum on guinea pig tracheal chains and its possible mechanism(s)

Indian Journal of Pharmacology

Volumn 37, Issue 2, 2005, Pages 111-115

  Boskabady, M H ^a   Kiani, S ^a   Azizi, H ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bronchodilator; Chlorpheniramine; Propranolol; Smooth muscle relaxant

Indexed keywords

CUMINUM CYMINUM EXTRACT; METHACHOLINE; PLANT EXTRACT; SODIUM CHLORIDE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BRONCHODILATATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG EFFECT; DRUG MECHANISM; GUINEA PIG; MALE; NONHUMAN; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

EID: 17444377492     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: 10.4103/0253-7613.15111     Document Type: Article

References (21)

1. Ishikawa T, Takayanagi T, Kitajima J. Water-soluble constituents of cumin: monoterpenoid glucosides. Chem Pharm Bull 2002;50:1471-8.
2. Yan JH, Tang KW, Zhong M, Deng NH. Determination of chemical components of volatile oil from Cuminum cyminum L. by gas chromatography-mass spectrometry. Se Pu 2002;20:569-72.
3. Takayanagi T, Ishikawa T, Kitajima J. Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin. Phytochemistry 2003;63:479-84.
4. th ed. Tehran: Tehran University Publications; 1990.
5. Agnihotri S, Vaidya AD. A novel approach to study antibacterial properties of volatile components of selected Indian medicinal herbs. Indian J Exp Biol 1996;34:712-5.
6. De M, De AK, Mukhopadhyay R, Banerjee AB, Miro M. Antimicrobial activity of Cuminum cyminum L. Ars Pharmaceutica 2003;44:257-9.
7. Singh G, Kapoor IP, Pandey SK, Singh UK, Singh RK.Studies on essential oils: part 10; antibacterial activity of volatile oils of some spices. Phytother Res 2002;16:680-2.
8. Dhandapani S, Subramanian VR, Rajagopal S, Namasivayam N. Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. Pharmacol Res 2002;46:251-5.
9. Srivastava KC. Extracts from two frequently consumed spices-cumin (Cuminum cyminum) and turmeric (Curcuma longa)-inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 1989;37:57-64.
10. Aruna K, Sivaramakrishnan VM. Anticarcinogenic effects of some Indian plant products. Food Chem Toxicol 1992;30:953-6
11. Gagandeep, Dhanalakshmi S, Mendiz E, Rao AR, Kale RK. Chemopreventive effects of Cuminum cyminum in chemically induced forestomach and uterine cervix tumors in murine model systems. Nutr Cancer 2003;47:171-80.
12. st ed. London: Oxford and IBH Publishing Co. Pvt. Ltd.; 2000.
13. Holroyde MC. The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Br J Pharmacol 1986;87:501-7.
14. Martin CA, Naline E, Bakdach H, Advenier C. Beta 3-adrenoceptor agonists, BRL 37344 and SR 58611A do not induce relaxation of human, sheep and guinea-pig airway smooth muscle in vitro. Eur Respir J 1994;7:1610-5.
15. Linden A, Bergendal A, Ullman A, Skoogh BE, Lofdahl CG. Salmeterol, formoterol, and salbutamol in the isolated guinea-pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism. Thorax 1993;48:547-53.
16. Popa VT, Simon P, Simon V. The effect of inhaled verapamil on resting bronchial tone and airway constriction induced by histamine and acetylcholine in normal and asthmatic subjects. Am Rev Respir Dis 1984;130:1006-13.
17. 3 muscarinic receptor inhibit smooth muscle contraction in rabbit trachea without increasing the release of acetylcholine. J Pharmacol Exp Ther 1992;263:773-9.
18. Buckle DR, Arch JR, Bowring NE, Foster KA, Taylor JF, Taylor SG, et al. Relaxant effect of potassium channel activators BRL 38227 and Pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by Glibenclamide and BRL 31660. Pulm Pharmacol 1993;6:77-86.
19. Perez-Guerrero C, Suarez, J, Herrera MD, Marhuenda E. Spasmolytic effect of tetrazepam on rat duodenum and guinea pig ileum. Pharmacol Res 1997; 35:493-7.
20. Miyahara Y, Kizawa Y, Sano M, Murakami H. Effect of organic and inorganic Ca2+ antagonists on acetylcholine induced contraction in molluscan (Mytilus edulis) smooth muscle. Gen Pharmacol 1993; 24:1419-23.
21. 2+ modulator in normal and albumin sensitised guinea-pig trachea. Eur J Pharmacol 1993;249:53-63.