Production of optically pure L-valine in fluidized and packed bed reactors with immobilized L-aminoacylase

Journal of Chemical Technology and Biotechnology

Volumn 74, Issue 5, 1999, Pages 403-408

  Bódalo Santoyo, Antonio ^a   Gomez Carrasco J L ^a   Gomez Gomez E ^a   Bastida Rodriquez, J ^a   Maximo Martin M F ^a   Hidalgo Montesinos, A M ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

Fluidized; Immobilized enzyme; L aminoacylase; L valine; Packed bed reactors

Indexed keywords

AMINO ACIDS; BIOREACTORS; CHEMICAL BONDS; ETHANOL; FLUIDIZED BEDS; PACKED BEDS; PURIFICATION; SEPARATION; SOLUBILITY;

AMINOACYLASE; VALINE;

ENZYME IMMOBILIZATION;

ALCOHOL; AMINOACYLASE; VALINE;

FLUIDIZED BED; PACKED BED; PROTEIN;

AMINO ACID SYNTHESIS; ARTICLE; BIOREACTOR; COVALENT BOND; ENZYME IMMOBILIZATION; FLOW RATE; FLUIDIZED BED; SOLUBILITY;

EID: 17344393981     PISSN: 02682575     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4660(199905)74:5<403::AID-JCTB51>3.0.CO;2-N     Document Type: Article

References (16)

1. Sato T and Tosa T, Production of L-aspartic acid. Bioprocess Technol (Ind Appl Immobilized Biocatal) 16:15-25 (1993).
2. Cheetham PSJ, Principles of industrial enzymology: Basis of utilization of soluble and immobilized enzymes in industrial processes, in Handbook of Enzyme Technology, Ed by Wiseman A, Ellis Horwood, Chichester, England. pp 54-146 (1985).
3. Chibata Y, Tosa T and Sato T, Application of immobilized biocatalysts in pharmaceutical and chemical industries, in Biotechnology, Enzyme Technology, Vol 7a, Ed by Rehm HJ and Reed G, Kenedy JF Vol Ed, Verlag Chemie Weinheim, Germany. pp 653-684 (1987).
4. Majón A, Iborra JL, Gómez JL, Gómez E, Bastida J and Bódalo A, Evaluation of the effectiveness factor along immobilized enzyme fixed-bed reactors: Design of a reactor with naringinase covalently immobilized into glycophase coated porous glass. Biotechnol Bioeng 30:491-497 (1987).
5. Bódalo A, Gómez JL, Gómez E, Bastida J and Máximo MF, Fluidized bed reactors operating with immobilized enzyme systems: design model and its experimental verification. Enzyme Microb Technol 17:915-922 (1995).
6. Weetall HH, Covalent coupling methods for inorganic supports, in Methods in Enzymology Vol 44, Ed by Mosbach K, Vol., Academic Press, New York. pp 134-148 (1976).
7. Bódalo A, Gómez JL, Gómez E, Bastida J, Leon G, Máximo MF and Hidalgo AM, Influence of pore size on covalent immobilization of L-aminoacylase on porous glass supports. Anales de Química, International Edition 94:78-83 (1998).
8. Švedas VJK, Galaev IJ, Borisov JL and Berezin IV, The interaction of amino acids with o-phthaldialdehyde: a kinetic study and spectrophotometric assay of the reaction product. Anal Biochem 101:188-195 (1980).
9. Biselli MF, Enzyme-catalyzed racemate separation of amino acids with integrated racemization using the conversion of DL-alanine to L-alanine as an example, PhD thesis, Inst Biotechnol Ber Forschungszent Juelich Juel 2581 (1992).
10. Richardson JF and Zaki WN, Sedimentation and fluidization. Trans Inst Chem Eng 32 (1) 35-53 (1954).
11. Coulson JM and Richardson JF, Fluidization, in Chemical Engineering II, Pergamon Press, Oxford, UK (1968).
12. Obón JM, Análisis de biorreactores a escala laboratorio para la resolución racémica de N-acetil-DL-aminoácidos con aminoacilasa fúngica, PhD thesis, University of Murcia, Spain (1991).
13. Greenstein JP and Winitz M, Valine, in Chemistry of Amino Acids, Vol 3, Part I, RE Krieger Pub Co, Malabar, USA. pp 2366-2380 (1984).
14. Han J, Jiang P and He B, The immobilization of aminoacylase and the resolution of DL-phenylalanine. Sci China, Ser B 34:641-650 (1991).
15. Sato T and Tosa T, Optical resolution of racemic amino acids by aminoacylase. Bioprocess Technol (Ind Appl Immobilized Biocatal) 16:3-14 (1993).
16. Hidalgo AM, Separación enzimática de los isómeros de DL-valina en reactores de lecho fijo y fluidizado, PhD thesis, CD Rom, Secretariado de Publicaciones de la Universidad de Murcia, Murcia, Spain (1997).