A pilot study of irinotecan (CPT-11) as single-agent therapy in patients with locally advanced or metastatic esophageal carcinoma

International Journal of Colorectal Disease

Volumn 18, Issue 4, 2003, Pages 330-334

  Muhr Wilkenshoff F ^a   Hinkelbein, W ^a   Ohnesorge, I ^a   Wolf, K J ^a   Riecken, E O ^a   Zeitz, M ^a   Scherubl H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Chemotherapy; CPT 11; Esophageal carcinoma; Irinotecan

Indexed keywords

ANTINEOPLASTIC AGENT; ATROPINE; IRINOTECAN; LOPERAMIDE; SEROTONIN; SEROTONIN ANTAGONIST;

ADENOCARCINOMA; ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; DRUG WITHDRAWAL; ESOPHAGUS CANCER; FEMALE; HUMAN; HUMAN CELL; MALE; METASTASIS; MONOTHERAPY; NAUSEA AND VOMITING; NEUTROPENIA; PILOT STUDY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

EID: 17344393081     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-002-0464-x     Document Type: Article

References (29)

1. Thomas RM, Sobin LH (1995) Gastrointestinal cancer. Cancer 75:154-170
2. Bareiß D, Stabenow R, Müller R, et al (2002) Current epidemiology of cancers of the esophagus and cardia in Germany. Dtsch Med Wochenschr 127:1367-1374
3. Higenberg AD, Carey RW, Wilkins EW Jr, et al (1988) Preoperative chemotherapy, surgical resection, and selective postoperative therapy for squamous cell carcinoma of the esophagus. Ann Thorac Surg 45:357-363
4. Ross P, Nicolson M, Cunningham J, et al (2002) Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion 5-fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol 20:1996-2004
5. Hsiang YH, Hertzberg R, Hecht S, Liu LF (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:1473-1478
6. Hsiang YH, Liu LF (1988) Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 48:1722-1726
7. Schneider E, Hsiang YH, Liu LF (1990) DNA topoisomerases as anti-cancer drug targets. Adv Pharmacol 21:149-183
8. Hsiang YH, Wu HY, Liu LF (1988) Topoisomerases: novel therapeutic targets in cancer chemotherapy. Biochem Pharmacol 37:1801-1802
9. Ilson DH, Saltz LB, Enzinger PC, et al (1999) Phase II trial of weekly irinotecan plus cisplatin in advanced esophageal cancer. J Clin Oncol 17:3270-3275
10. Ajani JA, Baker J, Pisters P, et al (2002) Phase II trial of weekly CPT-11 plus cisplatin in patients with advanced, untreated gastric or gastrooesophageal junction carcinoma. Cancer 94:641-646
11. Hecht JR, Parson LS, Rosen LS (1999) A phase II trial of irinotecan (CPT-11) in patients with adenocarcinoma of the esophagus and gastric cardia. Proc Am Soc Clin Oncol 18:287a
12. Scherübl H, Scherer H, Hoffmeister B (2002) Second esophageal cancers in head and neck cancer patients. N Engl J Med 346:1416-1417
13. Perng RP, Shih JF, Chen YM, Chou KC, Lee YC, Tsai CM (2002) A phase II study of single-agent docetaxel chemotherapy for non-small cell lung cancer. Jpn J Clin Oncol 30:429-434
14. Ajani JA, Ilson DH, Daugherty K, Pazdur R, Lynch PM, Kelsen DP (1994) Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus. J Natl Cancer Inst 86:1086-1091
15. Murthy SK, Prabhakaran PS, Chandeshekar M, et al (1990) Neoadjuvant cis-DDP in esophageal cancers: An experience at a regional cancer center in India. J Surg Oncol 45:173-176
16. Bleiberg H, Jacob J, Bedenne L, et al (1991) Randomized phase II trial of 5-fluorouracil and cisplatinum versus cisplatinum alone in advanced esophageal cancer. Proc Am Soc Clin Oncol 10:145a
17. Edzinli EZ, Gelber R, Desai DV, et al (1980) Chemotherapy of advanced esophageal carcinoma: Eastern cooperative oncology experience. Cancer 46:2149-2153
18. Bidoli P, Stani SC, De Candis D, Cortinovis D, Parra HS, Bajetta E (2001) Single-agent chemotherapy with vinorelbine for pretreated or metastatic squamous cell carcinoma of the esophagus. Tumori 87:299-302
19. Ilson DH, Bains M, Ginsberg RJ, et al (1997) Neoadjuvant therapy of esophageal cancer. Surg Oncol Clin N Am 6:723-740
20. Conti JA, Kemeny NE, Saltz LB, et al (1996) Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 14:709-715
21. Rougier P, Bugat R, Douillard JY, et al (1997) Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 15:251-260
22. Futatsuki K, Wakui A, Nakao I, et al (1994) Late phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer. Jpn J Cancer Chemother 21:1033-1038
23. Murphy BA, Douglas S, Cmelak A, et al (2000) Phase II trial of irinotecan (CPT-11) in metastatic or recurrent squamous cell carcinoma of the head and neck (SSCHN). Proceedings of the 5th International Conference on Head and Neck, vol 5, pp 108
24. Fukuola M, Niitani H, Suzuki A, et al (1992) A phase II study of CPT-11, a new derivate of camptothecin, for previously untreated non-small-cell lung cancer. J Clin Oncol 10: 16-20
25. Le Chevalier T, Ibrahim N, Chomy P, et al (1997) A phase II study of irinotecan (CPT-11) in patients with small-cell lung cancer progressing after initial response to first-line chemotherapy. Proc Am Soc Clin Oncol 16:450a
26. Verschraegen CF, Levy T, Kudelka AP, et al (1997) Phase II study of irinotecan in prior chemotherapy-treated squamous cell carcinoma of the cervix. J Clin Oncol 15:625-331
27. Sugiyama T, Nishida T, Ookura N, et al (1997) Is CPT-11 useful as a salvage chemotherapy for recurrent ovarian cancer? Proc Am Soc Clin Oncol 16:378a
28. Rothenberg ML, Eckardt JR, Kuhn JG, et al (1996) Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14:1128-1135
29. Pitot HC, Wender D, O'Connel MJ, et al (1994) A phase II trial of irinotecan (CPT-11) in patients with metastatic colorectal carcinoma: a North Central Cancer Treatment Group (NCCTG) study. Proc Am Soc Clin Oncol 13:573a