Pilot study with the monoclonal antibody IOR-C5 as a potential agent of radioimmunoscintigraphy in colorectal cancer;Ensayo piloto con el anticuerpo monoclonal IOR-C5 como agente potencial de la inmunocentelleografía del cáncer colorrectal

Revista Espanola de Medicina Nuclear

Volumn 20, Issue 4, 2001, Pages 282-288

  Oliva Gonzalez J P ^a,e   Pimentel, G ^a   Borron M ^a   Peralta, R ^b   Ortiz, R ^b   Oliver, B ^a   Diaz N ^a   Sanchez I ^a   Vazquez A M ^c   Baum, R P ^d  

^a Instituto Nacional de Oncología Y Radiobiología INOR   (Cuba)

^b Departamento de Ensayos Clínicos   (Cuba)

^c CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^d Centro de PET   (Germany)

^e INSTITUTO NACIONAL DE ONCOLOGÍA Y RADIOBIOLOGÍA   (Cuba)

Author keywords

CA 19.9; CEA; Colorectal cancer; Radioimmunoscintigraphy; Tumoral radioimmunoscintigraphy

Indexed keywords

MONOCLONAL ANTIBODY TC 99M; ANTIBODY CONJUGATE; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; DIAGNOSTIC AGENT; EPITOPE; HETEROPHILE ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RADIOPHARMACEUTICAL AGENT; TECHNETIUM; TUMOR ANTIGEN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RECURRENCE; CARCINOMA IN SITU; CLINICAL ARTICLE; COLORECTAL CANCER; CYSTADENOMA; DRUG ACCUMULATION; FEMALE; GASTROINTESTINAL TRACT SCINTISCANNING; HUMAN; IN VIVO STUDY; MALE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ADENOCARCINOMA; ADENOMA; ANIMAL; BIOSYNTHESIS; BLOOD; CHEMISTRY; CLINICAL TRIAL; COLORECTAL TUMOR; IMMUNOLOGY; MIDDLE AGED; MOUSE; PILOT STUDY; RADIOIMMUNOASSAY; SCINTISCANNING; TUMOR RECURRENCE;

ADENOCARCINOMA; ADENOMA; ADULT; AGED; ANIMALS; ANTIBODIES, HETEROPHILE; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CA-19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CARCINOMA IN SITU; COLORECTAL NEOPLASMS; EPITOPES; FEMALE; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; MALE; MICE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PILOT PROJECTS; RADIOIMMUNODETECTION; RADIOPHARMACEUTICALS; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TUMOR MARKERS, BIOLOGICAL;

EID: 17344386665     PISSN: 02126982     EISSN: 1578200X     Source Type: Journal    
DOI: 10.1016/s0212-6982(01)71959-3     Document Type: Article

References (21)

1. Registro Nacional del Cáncer, INOR, Cuba 1998.
2. Tormo BR, Gavilondo JV, Domínguez C, et al. CEA in colonic adenocarcinomas and precancerous lesions. An immunohistochemical study with a novel monoclonal antibody. APMIS 1989;97:1073-80.
3. 99mTc para la inmunogammagrafía de los tumores colorrectales. Resultados preliminares. Rev Esp Med Nuclear 1994;13:32-7.
4. Oliva JP, Pimentel G, Cascante L, et al. Ior-CEA-1: un nuevo anticuerpo monoclonal anti-CEA para la inmunogammagrafía de los tumores colorrectales. Resultados finales de un ensayo clínico fase I-II. Rev Esp Med Nuclear 1995;14:213-21.
5. Oliva JP, Dopico R, Borrón M, Velazco M, Pimentel G, Casanova F, et al. Radioimmunoscintigraphy of Colorectal Tumors with the Cuban Monoclonal Antibody ior-CEA-1. IAEA-SR-197/10. Srilanca. 1996.
6. Goldenberg DM. Oncofetal and other tumour associated antigens of the human digestive system. Curr Top Pathol 1976;63: 289-342.
7. 111-Labelled Monoclonal Antibody Imaging in Colorectal Cancer Patients. Sem Nucl Med 1993;XXIII, 2:19-113.
8. 131I labeled F(ab')2 fragments of monoclonal antibodes (19.9/anti-CEA radioimmunococtail) En: Winkler C, editor. Nuclear medicine in clinical oncology. Berlin, Heidelberg, New York: Springer 1986:197-206.
9. Vázquez AM, Tormo B, Velandia A, Giscombe R, Ansotegui I, Jeddi-Tehrani M, et al. Characterization of the Colorectal Antigen ior-C2. Hybridoma 1992;11:245-57.
10. Vázquez AM, Tormo B, Velandia A, Gómez CA, Alfonso M, Giscombe R, et al. Characterization of the Colorectal Antigen ior-C2. Year Immunol. Basilea 1993;7:137-45.
11. Quesada W, Pimentel G, Oliva J, Pérez G, Aguiar G, Sánchez I, et al. Radiomarcaje de un nuevo agente para la inmunocentellografía de tumores colorrectales. Rev Esp Med Nucl 1998;17:82-8.
12. Vázquez AM. Characterization of ior-C5 colorrectal tumor associated antigen. Inmunología 1995;14:130-2.
13. Baum RP, Maul FD, Lorenz M, et al. Immunoscintigraphy with anti-CA 19-9/CEA monoclonal antibodies: follow-up of liver metastasis (colonic cancer) before/after regional intra-arterial treatment. Nucl Med Commun 1985;6:697-99.
14. 99mTechnetium labeled anti-CEA monoclonal antibody (BW431/26) in the detection of colorrectal cancer. Eur J Nucl Med 1996;23:623-30.
15. Abdel-Nabi H, Doerr RJ, Radiolabelled Monoclonal Antibody Imaging (immunoscintigraphy) of Colorectal Cancers: Current Status and Future Perspectives. Am J Surg 1992;163:448-56.
16. Bosslet K, Steintrasser A, Schwartz A, et al. Qualitative considerations supporting the irrelevance of circulating serum for the CEA expressings carcinomas. Eur J Nucl Med 1988;14:523-8.
17. Doerr RJ, Abdel-Nabi H, Krag D, Mitchell E. Radiolabeled antibody imaging in the management of colorectal cancer. Results of a multicenter clinical study. Annals of Surgery 1991;214:118-24.
18. Nabi HA, Doerr RJ. Radiolabeled monoclonal antibody imaging (immunoscintigraphy) of colorectal cancers. Current status and future perspectives. Am J Surg 1992;163:448-56.
19. Abdel-Nabi H, Doerr RJ. Radiolabeled monoclonal antibody imaging (immunoscintigraphy) of colorectal cancers: current status and futures perspectives. Am J Surg 1992;163:448-56.
20. Bucheger DM, Deland F, Kim E, et al. Radiolabeled chimeric Anti-CEA monoclonal antibody compared with the original mouse monoclonal antibody for surgically treated colorectal carcinoma. J Nucl Med 1995;36:420-9.
21. Lee J, Stanley R, Sagel S, et al. CT appearance of the pelvis af-