Complications of combined intraoperative radiation (IORT) and external radiation (ERT) of the upper abdomen: An experimental model

Radiotherapy and Oncology

Volumn 38, Issue 3, 1996, Pages 205-214

  Schultz Hector, S ^a   Brechenmacher, P ^c   Dorr W ^a   Grab, J ^b   Kallfass, E ^a   Krimmel, K ^c   Kummermehr, J ^a   Sund, M ^a   Wilkowski, R ^c   Willich, N ^d   Zaspel, J ^b   Kramling H J ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d GSF MEDIS Institut ^*  (Germany)

Author keywords

Gastric ulceration; IORT; Radiation effect on arteries; Radiation injury to gastric mucosa; Upper abdominal ERT

Indexed keywords

ABDOMINAL SURGERY; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRAOPERATIVE PERIOD; PRIORITY JOURNAL; RABBIT; RADIATION INJURY; RADIOTHERAPY; STOMACH ULCER;

EID: 17344380308     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-8140(96)01707-0     Document Type: Article

References (32)

1. Gunderson, L.L. and Sosin, H. Adenocarcinoma of the stomach. Areas of failure in a reoperation series (second or symptomatic look): clinicopathologic correlation and implications for adjuvant therapy. Int. J. Radiat. Oncol. Biol. Phys. 8: 1-11, 1982.
2. Willich, N., Denecke, H. and Grab, J. Advantageous palliative effects and dose-related complications of ERT in nonresectable pancreatic cancer. In: Intraoperative Radiation Therapy, pp. 251-259. Editors: M. Abe and M. Takahashi. Pergamon Press, New York, 1991.
3. Abe, M., Takahashi, M., Shibamoto, A. and Ono, K. Intraoperative radiation therapy for carcinomas of the stomach and pancreas. Ann. Radiol. 32: 482-483, 1989.
4. Abe, M.Y., Shibamoto, M., Takahashi, M., Manabe, T., Tobe, T. and Inamoto, T. Intraoperative radiotherapy in carcinoma of the stomach and pancreas. World J. Surg. 11: 459-464, 1987.
5. Sindelar, W.F., Kinsella, T.J., Tepper, J.E., DeLaney, T.F., Maher, M.M., Smith, R., Rosenberg, S.A. and Glatstein, E. Randomized trial of intraoperative radiotherapy in carcinoma of the stomach. Am. J. Surg. 165: 178-187, 1993.
6. Shibamoto, Y., Manabe, T., Baba, N., Sasai, K., Takahashi, M., Tobe, T. and Abe, M. High dose, external beam and intraoperative radiotherapy in the treatment of resectable and unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys, 19: 605-611, 1990.
7. Evans, D.B., Termuhlen, P.M., Byrd, D.R., Ames, F.C., Ochran, T.G. and Rich, T.A. Intraoperative radiation therapy following pancreaticoduodenectomy. Ann. Surg. 218: 54-60, 1993.
8. Rübe, C., Wilkowski, R., Krämling, H.-J., Grab, J., Willich, N. and Lissner, J. Acute, subacute, and late side-effects of IORT in the upper abdomen. Strahlenther. Onkol. 168: 463-464, 1992.
9. Calvo, F.A., Aristo, J.J., Azinovic, I., Abuchaibe, O., Escude, L., Martinez, R., Tangco, E., Hernandez, J.L., Pardo, F. and Alvarez-Cienfuegos, J. Intraoperative and external radiotherapy in resected gastric cancer: updated report of a phase II trial. Int. J. Radiat. Oncol. Biol. Phys. 24: 729-736, 1992.
10. Ishihara, Y., Yamada, Y., Hata, Y. and Okabe, S. Species and strain differences in mepirizole-induced duodenal and gastric lesions. Dig. Dis. Sci. 28: 552-558, 1983.
11. Yokel, R.A. and Dickey, K.M. Mucosal injury and γ-irradiation produce persistent gastric ulcers in the rabbit. Gastroenterology 100: 1201-1205, 1994.
12. Findley, J.M., Newaisky, G.A., Sircus, W. and McManus, J. P.A. Role of gastric irradiation in management of peptic ulceration and esophagitis. Br. J. Med. 3: 769-771, 1974.
13. Carpender, J.W.J., Levin, E., Clapman, L.B. and Miller, R.E. Radiation therapy of peptic ulcer. Am. J. Radiol. 75: 374-379, 1956.
14. Gunderson, L.L. and James, A.M. Gastrointestinal tract radiation tolerance. In: Radiation Tolerance of Normal Tissues, pp. 277-298. Editors: J.M. Vaeth and J.L. Meyer. Front. Radiat. Ther. Oncol. 23, 1989.
15. Engelstad, R.B. The effect of roentgen rays on the stomach in rabbits. Am. J. Radiol. 40: 243-263, 1938.
16. Kitahora, T. and Guth, P.H. Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology 93: 810-817, 1987.
17. Gana, T.J., Huhlewych, R. and Koo, J. Focal gastric mucosal blood flow in aspirin-induced ulceration. Ann. Surg. 205: 399-403, 1987.
18. Hirose, H., Takeuchi, K. and Okabe, S. Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology 100: 1259-1265, 1991.
19. Young, C.M.A. and Hopewell, J.W. The effect of preoperative X-irradiation on the survival and blood flow of pedicle skin flaps in the pig. Int. J. Radiat. Oncol. Biol. Phys. 9: 865-870, 1983.
20. Keyeux, A., Dunjic, A., Royer, E., Jovanovic, D. and Van de Merckt, J. Late functional and circulatory changes in rats after local irradiation. Int. J. Radiat. Biol. 20: 7-25, 1971.
21. Hoopes, P.J., Gillette, E.L. and Withrow, S.J. Intraoperative irradiation of the canine abdominal aorta and vena cava. Int. J. Radiat. Oncol. Biol. Phys. 13: 715-722, 1987.
22. Gillette, E.L., Powers, B.E., McChesney, S.L. and Withrow, S.J. Aortic wall injury following intraoperative irradiation. Int. J. Radiat. Oncol. Biol. Phys. 15: 1401-1406, 1988.
23. Gillette, E.L., Powers, B.E., McChesney, S.L., Park, R.D. and Withrow, S.J. Response of aorta and branch arteries to experimental intraoperative irradiation. Int. J. Radiat. Oncol. Biol. Phys. 17: 1247-1255, 1989.
24. Sindelar, W.F., Tepper, J., Travis, E.L. and Terrill, R. Tolerance of retroperitoneal structures to intraoperative radiation. Ann. Surg. 196: 601-608, 1982.
25. Sindelar, W.F., Tepper, J.E., Kinsella, T.J., Barnes, M., DeLuca, A.M., Terrill, R., Matthews, D., Anderson, W.J., Bollinger, B.K. and Johnstone, P.A.S. Late effects of intraoperative radiation therapy on retroperitoneal tissues, intestine, and bile duct in a large animal model. Int. J. Radiat. Oncol. Biol. Phys. 29: 781-788, 1994.
26. Schultz-Hector, S., Kallfass, E. and Sund, M. Strahlenfolgen an großen Arterien. Übersicht über klinische und experimentelle Daten. Strahlenther. Onkol. 171: 427-436, 1995.
27. Hirst, D.G., Denekamp, J. and Travid, E.L. The response of mesenteric blood vessels to irradiation. Radiat. Res. 77: 259-275, 1979.
28. Moore, J.G. and Bjorkman, D.J. NSAID-induced gastropathy in the elderly: understanding and avoidance. Geriatrics 44: 51-57, 1989.
29. Brooks, F.P. Peptic ulcer - current status. Clin. Invest. Med. 10: 108-116, 1987.
30. Jordan, P.H. and Morrow, C. Perforated peptic ulcer. Surg. Clin. North Am. 68: 315-329, 1988.
31. Dörr, W., Kallfass, E., Berg, D. and Kummermehr, J. Kombinierte intraoperative und externe Bestrahlung der A. coeliaca beim Kaninchen: Auswirkungen auf die Durchblutung der Magenschleimhaut. Strahlenther. Onkol. (in press).
32. Kallfass, E., Krämling, H.-J. and Schultz-Hector, S. Early inflammatory reaction of the rabbit coeliac artery wall after combined intraoperative (IORT) and external (ERT) irradiation. Radiother. Oncol. (in press).