Comparison between four and eight cycles of intensive chemotherapy in adult acute myeloid leukemia: A randomized trial of the Finnish Leukemia Group

Leukemia

Volumn 12, Issue 7, 1998, Pages 1041-1048

  Elonen, E ^a   Almqvist, A ^b   Hanninen A ^c   Jansson, S E ^a   Jarventie G ^d   Koistinen, P ^e   Koivunen, E ^d   Lahtinen, R ^c   Lehtinen, M ^d   Nousiainen, T ^c   Pelliniemi, T T ^f   Rajamaki A ^f   Remes, K ^f   Timonen, T ^e   Vilpo, J ^e   Volin, L ^a   Ruutu, T ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b VAASA CENTRAL HOSPITAL   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e OULU UNIVERSITY HOSPITAL   (Finland)

^f TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Acute leukemia; Drug therapy; Myeloid; Postremission therapy; Survival; Treatment outcome

Indexed keywords

ACLARUBICIN; AMSACRINE; ANTINEOPLASTIC AGENT; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; PREDNISONE; TIOGUANINE; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; REMISSION;

EID: 17344373829     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401068     Document Type: Article

References (11)

1. Stone RM, Mayer RJ. Treatment of the newly diagnosed adult with de novo acute myeloid leukemia. Hematol Oncol Clin North Am 1993; 7: 47-64.
2. Cassileth PA, Harrington DP, Hines JD, Oken MM, Mazza JJ, McGlave P, Bennett JM, O'Connel MJ. Maintenance chemotherapy prolongs remission duration in adult acute nonlymphocytic leukemia. J Clin Oncol 1988; 6: 583-587.
3. Bloomfield C. Postremission therapy in acute myeloid leukemia. J Clin Oncol 1985; 3: 1570-1572.
4. Mayer RJ, Davis RB, Schiffer CA, Berg DT, Powell BL, Schulman P, Omura GA, Moore JO, McIntyre OR, Frei E III. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. New Engl J Med 1994; 331: 896-903.
5. Cassileth PA, Lynch E, Hines JD, Oken MM, Mazza JJ, Bennett JM, McGlave PB, Edelstein M, Harrington DP, O'Connell MJ. Varying intensity of postremission therapy in acute myeloid leukemia. Blood 1992; 79: 1924-1930.
6. Sauter C, Berchtold W, Fopp M, Grathwohl A, Imbach P, Maurice P, Tschopp L, Fliender V, Cavalli F. Acute myelogenous leukaemia: maintenance chemotherapy after early consolidation treatment does not prolong survival. Lancet 1984; 1: 379-382.
7. Preisler H, Davis RB, Kirshner J, Dupre E, Richards F, Hoagland HC, Kopel S, Levy RN, Carey R, Schulman P, Gottlieb AJ, McIntyre OR. Comparison of three remission induction regimens and two post-induction strategies for the treatment of acute nonlymphocytic leukemia: A Cancer and Leukemia Group B study. Blood 1987; 69: 1441-1449.
8. Palva IP, Almqvist A, Elonen E, Hänninen A, Jouppila J, Järventie G, Koivunen E, Kätkä K, Lahtinen R, Oivanen T, Pelliniemi T-T, Rajamäki A, Remes K, Ruutu T, Timonen T, Wasastjerna C, Vilpo J, Volin L, Vuopio P. Value of maintenance therapy with chemotherapy or Interferon during remission of acute myeloid leukaemia. Eur J Haematol 1991; 47: 229-233.
9. Raza A, Preisler HD, Browman GP, Larson RA, Rustum YM, Goldberg J, Vogler R, Miller KA, Bennett J, Kukla C. Long-term outcome of patients with acute myelogenous leukemia: the role of maintenance therapy, consolidation therapy and the predictive value of two in vitro assays. Leuk Lymphoma 1993; 10: 57-66.
10. Mandelli F, Vegna ML, Avvisati G, Amadori S, Spadea A, Cacciola E, Cantore N, De Laurrenzi A, De Rosa C, Floritoni G, Gabbas A, Liso V, Malleo C, Miraglia E, Montillo M, Perricone R, Peta A, Ricciuti F, Petti MC. A randomized study of the efficacy of postconsolidation therapy in adult acute nonlymphocytic leukemia: a report of the Italian Cooperative Group GIMEMA. Ann Hematol 1992; 64: 166-172.
11. Vogler WR, Weiner RS, Moore JO, Omura GA, Bartolucci AA, Stagg M. Long-term follow-up of a randomized post-induction therapy trial in acute myelogenous leukemia (a Southeastern Cancer Study Group trial). Leukemia 1995; 9: 1456-1460.