A randomized controlled study for the evaluation of the activity of a triple combination of zidovudine, thymosin-α1 and interferon-α in HIV- infected individuals with CD4 counts between 200 and 500 cells/mm3

Antiviral Therapy

Volumn 3, Issue 2, 1998, Pages 103-111

  Vella, Stefano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; THYMOSIN ALPHA1; ZIDOVUDINE;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; FEMALE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAMUSCULAR DRUG ADMINISTRATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VIRUS INHIBITION; VIRUS LOAD;

EID: 17344373352     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Fauci AS. Host factors and the pathogenesis of HIV-induced disease. Nature 1996; 384: 529-534.
2. Delta Coordinating Committee: Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 1996; 348:283-291.
3. Eron JJ, Benoit SL, Jemsek J, MacArthur RD, Santana J, Quinn JB, Kuritzkes DR, Falloon MA & Rubin M. Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4 per cubic millimeter. New of England Journal of Medicine 1995; 333:1662-1669.
4. Hammer SM, Katzenstein DA & Hughes MD. A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. New England Journal of Medicine 1996; 335:1081-1090.
5. Katlama C, Ingrand D, Loveday C, Clumeck N, Mallolas J, Staszewski S, Johnson M, Hill AM, Pearce G & McDade H. Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. Journal of the American Medical Association 1996; 276:118-125.