Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers

Cancer Epidemiology Biomarkers and Prevention

Volumn 6, Issue 12, 1997, Pages 1039-1042

  Rothman, Nathaniel ^a   Talaska, Glenn ^b   Hayes, Richard B ^a   Bhatnagar, Vijay K ^d   Bell, Douglas A ^c   Lakshmi, Vijaya M ^e   Kashyap, Sri K ^d   Dosemeci, Mustafa ^a   Kashyap, Rekha ^d   Hsu, Fong F ^e   Jaeger, Marlene ^b   Hirvonen, Ari ^c   Parikh, Dinesh J ^d   Davis, Bernard B ^e   Zenser, Terry V ^e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (India)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINE; BENZIDINE; CARCINOGEN; TOBACCO SMOKE;

ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER RISK; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA ADDUCT; HUMAN; OCCUPATIONAL CANCER; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; URINE PH;

ANALYSIS OF VARIANCE; BENZIDINES; DNA ADDUCTS; GENOTYPE; HUMANS; HYDROGEN-ION CONCENTRATION; OCCUPATIONAL EXPOSURE; URINE; UROTHELIUM;

EID: 17344373048     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Kadlubar, F. F., Miller, J. A., and Miller, E. C. Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis. Cancer Res., 37: 805-814, 1977.
2. Babu, S. R., Lakshmi, V. M., Hsu, F. F., Zenser, T. V., and Davis, B. B. Role of N-glucuronidation in benzidine-induced bladder cancer in dog. Carcinogenesis (Lond.), 13: 1235-1240, 1992.
3. Babu, S. R., Lakshmi, V. M., Hsu, F. F., Kane, K. E., III, Zenser, T. V., and Davis, B. B. N-Acetylbenzidine-N′-glucuronidation by human, dog, and rat liver. Carcinogenesis (Lond.), 14: 2605-2611, 1993.