Polypyrimidine tract-binding protein binds to the leader RNA of mouse hepatitis virus and serves as a regulator of viral transcription

Journal of Virology

Volumn 73, Issue 1, 1999, Pages 772-777

  Hsin Pai, L I ^a   Huang, Peiyong ^a   Park, Sungmin ^a   Lai, Michael M C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PYRIMIDINE; RNA BINDING PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; HEPATITIS VIRUS; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; VIRUS TRANSCRIPTION;

EID: 17344372905     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.1.772-777.1999     Document Type: Article

References (26)

1. Ali, N., and A. Siddiqui. 1995. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J. Virol. 69:6367-6375.
2. Baker, S. C., and M. M. C. Lai. 1990. An in vitro system for the leader-primed transcription of coronavirus mRNAs. EMBO J. 9:4173-4179.
3. Bothwell, A. L. M., D. W. Ballard, W. M. Philbrick, G. Lindwall, S. E. Mather, M. M. Bridgett, S. F. Jamison, and M. A. Garcia-Blanco. 1991. Murine polypyrimidine tract binding protein. J. Biol. Chem. 266:24657-24663.
4. 14C-labeled amino acids. Clin. Chem. 28:766-781.
5. Budzilowicz, C. J., S. P. Wilczynski, and S. R. Weiss. 1985. Three intergenic regions of coronavirus mouse hepatitis virus strain A59 genome RNA contain a common nucleotide sequence that is homologous to the 3′ end of the viral mRNA leader sequence. J. Virol. 53:834-840.
6. Dreyfuss, G., M. J. Mantunis, S. Pinol-Roma, and C. G. Burd. 1993. hnRNP proteins and the biogenesis of mRNA. Annu. Rev. Biochem. 62:289-321.
7. Furuya, T., and M. M. C. Lai. 1993. Three different cellular proteins bind to complementary sites on the 5′-end-positive and 3′-end-negative strands of mouse hepatitis virus RNA. J. Virol. 67:7215-7222.
8. Garcia-Blanco, M. A., S. F. Jamison, and P. A. Sharp. 1989. Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev. 3:1874-1886.
9. Ghetti, A., S. Pinol-Roma, W. M. Michael, C. Morandi, and G. Dreyfuss. 1992. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20:3671-3678.
10. Gil, A., P. A. Sharp, S. F. Jamison, and M. A. Garcia-Blanco. 1991. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev. 5:1224-1236.
11. Hellen, C. U. T., G. W. Witherell, M. Schmid, S. H. Shin, T. V. Pestova, A. Gil, and E. Wimmer. 1993. A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. Proc. Natl. Acad. Sci. USA 90:7642-7646.
12. Hirano, N., K. Fujiwara, S. Hino, and M. Matsumoto. 1974. Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch. Gesamte Virusforsch. 44:298-302.
13. Jeong, Y. S., and S. Makino. 1994. Evidence for coronavirus discontinuous transcription. J. Virol. 68:2615-2623.
14. Joo, M., and S. Makino. 1992. Mutagenic analysis of the coronavirus intergenic consensus sequence. J. Virol. 66:6330-6337.
15. Kaminski, A., S. L. Hunt, J. G. Patton, and R. J. Jackson. 1995. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA 1:924-938.
16. Lai, M. M. C. 1986. Coronavirus leader RNA-primed transcription: an alternative mechanism to RNA splicing. BioEssays 5:257-260.
17. Lai, M. M. C., P. R. Brayton, R. C. Armen, C. D. Patton, C. Pugh, and S. A. Stohlman. 1981. Mouse hepatitis virus A59: mRNA structure and genetic localization of the sequence divergence from the hepatotropic strain MHV-3. J. Virol. 39:823-334.
18. Lai, M. M. C., and D. Cavanagh. 1997. The molecular biology of coronaviruses. Adv. Virus Res. 48:1-100.
19. Lai, M. M. C., C.-L. Liao, Y.-J. Lin, and X. Zhang. 1994. Coronavirus: how a large RNA viral genome is replicated and transcribed. Infect. Agents Dis. 3:98-105.
20. Lai, M. M. C., C. D. Patton, R. S. Baric, and S. A. Stohlman. 1983. The presence of leader sequences in the mRNA of mouse hepatitis virus. J. Virol. 46:1027-1033.
21. La Monica, N., K. Yokomori, and M. M. C. Lai. 1992. Coronavirus mRNA synthesis: identification of novel transcription initiation signals which are differentially regulated by different leader sequences. Virology 188:402-407.
22. Lee, H.-J., C.-K. Shieh, A. E. Gorbalenya, E. V. Koonin, N. La Monica, J. Tuler, A. Bagdzhadzhyan, and M. M.-C. Lai. 1991. The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology 180:567-582.
23. Leibowitz, J. L., K. C. Wilhelmsen, and C. W. Bond. 1981. The virus-specific intracellular RNA species of two murine coronaviruses: MHV-A59 and MHV-JHM. Virology 114:39-51.
24. Li, H.-P., X. Zhang, R. Duncan, L. Comai, and M. M. C. Lai. 1997. Heterogeneous nuclear ribonucleoprotein Al binds to the transcription-regulatory region of mouse hepatitis virus RNA. Proc. Natl. Acad. Sci. USA 94:9544-9549.
25. Liao, C.-L., and M. M. C. Lai. 1994. Requirement of the 5′ end genomic sequence as an upstream cis-acting element for coronavirus subgenomic mRNA transcription. J. Virol. 68:4727-4737.
26. Lin, Y.-J., X. Zhang, R. C. Wu, and M. M. C. Lai. 1996. The 3′ untranslated region of coronavirus RNA is required for subgenomic mRNA transcription from a defective interfering RNA. J. Virol. 70:7236-7240.