In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia

Leukemia

Volumn 12, Issue 11, 1998, Pages 1749-1755

  Feldman, E J ^a   Seiter, K ^a   Chiao, J W ^a   Halicka, H D ^a   Traganos, F ^a   Fatora, S R ^b   McMichael, J ^b   Baskind, P ^a   Goff, H ^a   Beer, M ^a   Ahmed, T ^c   Darzynkiewicz, Z ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b Milkhaus Laboratories   (United States)

^c Munger Pavilion ^*

Author keywords

Acute leukemia; Chorionic gonadotrophin

Indexed keywords

CHORIONIC GONADOTROPIN; LEVAMISOLE; PROTEIN BCL 2;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLAST CELL; BONE MARROW CELL; CANCER HORMONE THERAPY; CELL CYCLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL TRIAL; CYTOPENIA; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 17344372698     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401196     Document Type: Article

References (21)

1. Marcillac I, Troalen F, Bidart JM, Ghillani P, Ribrag V, Escudier B, Malassagne B, Droz JP, Llhomme C, Rougier P, Davillard P, Prade M, Lugagne PM, Richard F, Poynard T, Bohuon C, Wands J, Bellet D. Free human chorionic gonadotrophin β subunit in gonadal and nongonadal neoplasms. Cancer Res 1992; 52: 3901-3907.
2. Gailani A, Chu TM, Nussbaum A, Ostrander M, Christoff N. Human chorionic gonadotrophin (HCG) in nontrophoblastic neoplasms. Cancer 1976; 38: 1684-1686.
3. Rodway MR, Rao CV. A novel perspective in the role of human chorionic gonadotrophin during pregnancy and in gestational trophoblastic disease. Early Pregnancy: Biology and Medicine 1993; 1: 176-187.
4. Acevedo HF, Tong JY, Hartsock RJ. Human chorionic gonadotrophin-beta subunit gene expression in cultured human fetal and cancer cells of different types and origins. Cancer 1995; 76: 1467-1475.
5. Acevedo HF, Hartsock RJ. Metastatic phenotype correlates with high expression of membrane-associated complete β-human chorionic gonadotrophin in vivo. Cancer 1996; 78: 2388-2399.
6. Kellen JA, Kolin A, Mirakian A, Acevedo HF. Effects of antibodies to choriogonadotrophin in malignant growth. Cancer Immunol Immunother 1982; 13: 2-4.
7. Lunardi-lskandar Y, Bryant JL, Zeman RA, Lam VH, Samaniego F, Besnier JM, Hermans P, Thierry A, Gill P, Gallo RC. Tumorgenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 1995; 375: 64-68 (Erratum) Nature 1995; 376: 447.
8. Gill PS, Lunardi-lskandar Y, Louie S, Tulpulem A, Zheng T, Espina BM, Besnier JM, Hermans P, Levine AM, Bryant JL, Gallo RC: The effects of preparations of human chorionic gonadotrophin on aids-related Kaposi's sarcoma. New Engl J Med 1996; 335: 1261-1269.
9. Gill PS, McLaughlin T, Espina BM, Tulpule A, Louie S, Lunardi-Iskandar Y, Gallo RC. Phase I study of human chorionic gonadotropin given subcutaneously to patients with acquired immunodeficiency syndrome-related mucocutaneous Kaposi's sarcoma. J Natl Cancer Inst 1997; 89: 1797-1802.
10. McMichael J. Immunotherapeutic methods and compositions employing antigens characteristic of malignant neoplasms. US Patent Sept 8, 1987 No. 4, 692, 332.
11. Xu W, Seiter K, Feldman E, Ahmed T, Chiao JW. The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin of phosphoglucose isomerase. Blood 1996; 87: 4502-4506.
12. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucelotidyl transferase and nick translation assays. Cancer Res 1993; 53: 1945-1951.
13. Li X, Gong J, Feldman EJ, Seiter K, Traganos F, Darzynkiewicz Z. Apoptotic cell death during treatment of leukemias. Leuk Lymphoma 1994; 13 (Suppl. 1): 65-70.
14. Seiter K, Feldman EJ, Halicka D, Traganos F, Darzynkiewicz Z, Lake D, Ahmed T. Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia. J Clin Oncol 1997; 15: 44-51.
15. Meloni G, Foa R, Vignetti M, Guarinni A, Fena S, Tosti S, Tos AG, Mandelli F. Interleukin-2 may induce prolonged remissions in advanced acute myelogenous leukemia. Blood 1994; 84: 2158-2163.
16. Van Sloten K, Wiernik PH, Schiffer CA, Schimpff SS. Evaluation of levamisole as an adjuvant to chemotherapy for treatment of ANLL. Cancer 1983; 51: 1576-1580.
17. Krown SE. Kaposi's sarcoma - what's human chorionic gonadotrophin got to do with it? New Engl J Med 1996; 335: 1309-1310.
18. Tao YX, Bao S, Ackermann DM, Lei ZM, Rao CH. Expression of luteinizing hormone/human chorionic gonadotrophin receptor gene in benign prostatic hyperplasia and in prostate carcinoma in humans. Biol Reproduction 1997; 56: 67-72.
19. Lapthorn AJ, Harris DC, Littlejohn A, Lustbaden JW, Canfield RE, Machin EJ, Morgan FJ, Isaacs NW. Crystal structure of human chorionic gonadotrophin. Nature 1994; 369: 455-461.
20. Acevedo HF, Raikow RB, Powell JE, Stevens VC. Effects of immunization against HCG on the growth of transplanted Lewis lung carcinoma and spontaneous mammary adenocarcinoma in mice. Cancer Detec Prev 1987; 1 (Suppl.): 477-486.
21. Milkhaus Laboratories. Data on file.