Selective impairment of endothelium-mediated vasodilation in liver transplant recipients with cyclosporin a-induced hypertension

Hepatology

Volumn 27, Issue 2, 1998, Pages 332-338

  Albillos, Agustín ^a,b   Cacho, Guillermo ^a   Barrios, César ^a   Alvarez Mon, Melchor ^c   Rossi, Irma ^a   Gómez Arnau, Juán ^a   Pérez Páramo, María ^a   Calleja, Jose Luis ^a   Muñoz, Javier ^a   Torres, María Teresa ^a   Daza, Rosa ^a   Cuervas Mons, Valentín ^a   Escartín, Pedro ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; FEMALE; GRAFT REJECTION; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

ADULT; CYCLOSPORINE; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION; LIVER TRANSPLANTATION; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; NITROPRUSSIDE; PHENYLEPHRINE; REGIONAL BLOOD FLOW; VASCULAR RESISTANCE; VASODILATION;

EID: 17344370077     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270203     Document Type: Article

References (8)

1. Textor SC, Canzanello VJ, Taler SJ, Wilson DJ, Schwartz L, Augustine J, Raymer JM, et al. Cyclosporine-induced hypertension after transplantation. Mayo Clin Proc 1994;69:1182-1193.
2. Scherrer U, Vissing SF, Morgan BJ, Rollins JA, Tindall RS, Ring S, Hanson P, et al. Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med 1990;323:693-699.
3. Monsour HP, Wood RP, Dyer CH, Galati JS, Ozaki CF, Clark JH. Renal insufficiency and hypertension as long-term complications in liver transplantation. Semin Liver Dis 1995;15:123-132.
4. Textor SC. De-novo hypertension after liver transplantation. Hypertension 1993;22:257-267.
5. Richards NT, Poston L, Hilton PJ. Cyclosporin A inhibits endothelium-dependent, prostanoid-induced relaxation in human subcutaneous resistance vessels. J Hypertens 1990;8:159-163.
6. Rego A, Vargas R, Wroblewska B, Foegh ML, Ramwell PW. Attenuation of vascular relaxation and cyclic GMP responses by cyclosporin A. J Pharm Exp Ther 1990;252:165-170.
7. Takenaka T, Hashimoto Y, Epstein M. Diminished acetylcholine-induced vasodilation in renal microvessels of cyclosporine-treated rats. J Am Soc Nephrol 1992;3:42-50.
8. Gallego MJ, Farre AL, Riesco A, Monton M, Grandes SM, Barat A, Herando L, et al. Blockade of endothelium-dependent responses in conscious rats by cyclosporin A: effect of L-arginine. Am J Physiol 1993;264:H708-H714.