Identification of the location of the colonic pacemakers: A histologic study

Frontiers in Bioscience

Volumn 10, Issue 2, 2005, Pages 1661-1665

  Shafik, Ahmed ^a,c   El Sibai, Olfat ^b   Shafik, Ismail A ^a   Shafik, Ali A ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b MENOUFIA UNIVERSITY   (Egypt)

^c NONE   (Egypt)

Author keywords

C Kit; Electric waves; Image analyzer; Interstitial cells of Cajal; Pacemaker node and bundle

Indexed keywords

ADULT; ARTICLE; CADAVER; COLON MOTILITY; COLON MUCOSA; CONTROLLED STUDY; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; PACEMAKER; STATISTICAL ANALYSIS; TISSUE SECTION; TRANSVERSE COLON;

ORYCTOLAGUS CUNICULUS;

EID: 17244381003     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1650     Document Type: Article

References (23)

1. Ward, S. M., and K. M. Sanders: Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol 281, 602-611 (2001)
2. Daniel, E. E., J. Thomas, M. Ramnarain, T. J. Bowes and J. Jury: Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle? Neurogastroenterol Motil 13, 297-307 (2001)
3. Liu, L. W. C and J. D. Huizinga: Electrical coupling of circular muscle to longitudinal muscle and interstitial cells of Cajal in canine colon. J Physiol (Lond) 470, 445-461 (1993)
4. Rumessen, J. J., H. B., Mikkelsen and L. Thuneberg: Ultrastructure of interstitial cells of Cajal associated with deep muscular plexus of human small intestine. Gastroenterology 102, 56-68 (1992)
5. Vanderwinden J. M., J. J. Rumessen, H. Liu: Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Gastroenterology 111, 901-910 (1996)
6. Thuneberg, L: Interstitial cells of Cajal: intestinal pacemaker cells? Adv Anat Embryol Cell Biol 71, 1-130 (1982)
7. Wester, T., L. Eriksson, Y. Olsson, L. Olsen: Interstitial cells of Cajal in the human fetal small bowel as shown by c-kit immunohistochemistry Gut 44, 65-71 (1999)
8. Liu, L. W. C., L. Thuneberg and J. D. Huizinga: Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves. Am J Physiol 266, 485-496 (1994)
9. Faussone-Pellegrini, M. S., D. Pantalone, C. Cortesini: Smooth muscle cells, interstitial cells of Cajal and myenteric plexus relationships in the human colon. Acta Anat 139, 31-44 (1990)
10. Mazzia, C., C. Porcher, Y. Jule: Ultrastructural study of relationships between c-kit immunoreactive interstitial cells and other cellular elements in the human colon. Histochem Cell Biol 5, 401-408 (2000)
11. Maeda, H., A. Yamagata, S. Nishikawa: Requirement of c-kit for development of intestinal pacemaker system.
12. Torihashi, S, S. M., Ward, S. I., Nishikawa: C-Kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 280, 97-111 (1995)
13. Ward, S. M., A. J. Burns, S. Torihashi: Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine. J Physiol 480, 91-97 (1994)
14. Huizinga, J. D., L. Thuneberg , M. Kluppel: W/kit gene required for intestinal pacemaker activity. Nature 373, 347-349 (1995)
15. Ward, S. M., A. J. Burns, S. Torihashi: Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 269, C1577-C1585 (1995)
16. Shafik, A., O. El-Sibai, A. A. Shafik: Electrophysiologic identification of the location of the colonic pacemakers. A human study. Front in Biosci 7, b1-5 (2002)
17. Shafik, A., A. A, Shafik, O. El-Sibai , I. Ahmed: Electrophysiologic identification of the location of the colonie pacemakers in humans. Further study. J Invest Surg 16, 289-297 (2003)
18. nd edn, Adam Hilger, Bristol and Philadelphia, 17-26 (1989)
19. Shafik, A: A study of the origin of the electric activity of the rectum: Is it neurogenic or myogenic? Spinal Cord 36, 548-553 (1998)
20. Shafik, A: On the origin of the rectal electric waves: Further study. Dis Colon Rectum 42, 1626-1631 (1999)
21. Burns, A. J., A. E. J. Lomax, S. Torihashi: Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Nat Acad Sci USA 93, 12008-12013 (1996)
22. Sarna, S. K., R. Condon, V. Cowles: Colonie migrating and nonmigrating motor complexes in dogs. Am J Physiol 246, G355-G360 (1984)
23. Soffer, E. E., P. Scalabrini, D. L. Wingate: Prolonged ambulatory monitoring of human colonie motility. Am J Physiol 256, G601-G606 (1989)