What is the role of mitomycin C in advanced gastric cancer?

Onkologie

Volumn 28, Issue 3, 2005, Pages 125-126

  Chong, Geoff ^a   Cunningham, David ^a,b  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CISPLATIN; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; METHOTREXATE; MITOMYCIN C; OXALIPLATIN; MITOMYCIN;

ADVANCED CANCER; CANCER COMBINATION CHEMOTHERAPY; CLINICAL TRIAL; DOSE RESPONSE; DRUG TOLERABILITY; EDITORIAL; HUMAN; MONOTHERAPY; SIDE EFFECT; STOMACH CANCER; CLASSIFICATION; CONTROLLED CLINICAL TRIAL; HOSPITALIZATION; RANDOMIZED CONTROLLED TRIAL; STOMACH TUMOR; TREATMENT OUTCOME;

HUMANS; MITOMYCIN; RANDOMIZED CONTROLLED TRIALS; SEVERITY OF ILLNESS INDEX; STOMACH NEOPLASMS; TREATMENT OUTCOME;

EID: 17244364607     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083421     Document Type: Editorial

References (16)

1. Glimelius B, Ekstrom K, Hoffman K, Graf W, Sjoden PO, Haglund U, Svensson C, Enander LK, Linne T, Sellstrom H, Heuman R: Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer. Ann Oncol 1997;8:163-168.
2. Pyrhonen S, Kuitunen T, Nyandoto P, Kouri M: Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer. Br J Cancer 1995;71:587-591.
3. Webb A, Cunningham D, Scarffe JH, Harper P, Norman A, Joffe JK, Hughes M, Mansi J, Findlay M, Hill A, Oates J, Nicolson M, Hickish T, O'Brien M, Iveson T, Watson M, Underhill C, Wardley A, Meehan M: Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol 1997;15:261-267.
4. Ross P, Nicolson M, Cunningham D, Valle J, Seymour M, Harper P, Price T, Anderson H, Iveson T, Hickish T, Lofts F, Norman A: Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol 2002;20:1996-2004.
5. Sumpter KA, Harper-Wynne C, Cunningham D, Oates J, Tebbutt N, Iveson T: Randomised, multicenter phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer: Confirmation of dose escalation. Proc Am Soc Clin Oncol 2003;21:Abstr 1031.
6. Ajani JA, Van Cutsem E, Moiseyenko S, Tjulandin S, Fodor M, Majlis A: Docetaxel, cisplatin, 5-fluorouracil compared to cisplatin and 5-fluorouracil for chemotherapy-naïve patients with metastatic or locally recurrent, unresectable gastric carcinoma: Interim results of a randomized phase III trial (V325). Proc Am Soc Clin Oncol 2003;22:Abstr 999.
7. Vanhoefer U, Rougier P, Wilke H, Ducreux MP, Lacave AJ, Van Cutsem E, Planker M, Santos JG, Piedbois P, Paillot B, Bodenstein H, Schmoll HJ, Bleiberg H, Nordlinger B, Couvreur ML, Baron B, Wils JA: Final results of a randomized phase III trial of sequential high-dose methotrexate, fluorouracil, and doxorubicin versus etoposide, leucovorin, and fluorouracil versus infusional fluorouracil and cisplatin in advanced gastric cancer: A trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group. J Clin Oncol 2000;18:2648-2657.
8. Roth AD, Maibach R, Falk S, Stupp R, Saletti P, Kaberle D, Borner MM, Honegger HP, Leslie M, Fazio N: Docetaxel-cisplatin-5FU versus docetaxelcisplatin versus epirubicin-cisplatin-5FU as systemic treatment for advanced gastric carcinoma: A randomized phase II trial of the Swiss Group for Clinical Cancer Research. Proc Am Soc Clin Oncol 2004;22:Abstr 4020.
9. Rudi J, Werle S, Bergtholdt D, Hofheinz RD: Infusional 5-fluorouracil and mitomycin C: An effective regimen in the treatment of advanced gastric cancer. Onkologie 2005;28: DOI: 10.1159/000083244.
10. Tebbutt NC, Norman A, Cunningham D, Iveson T, Seymour M, Hickish T, Harper P, Maisey N, Mochlinski K, Prior Y, Hill M: A multicentre, randomised phase III trial comparing protracted venous infusion (PVI) 5-fluorouracil (5-FU) with PVI 5-FU plus mitomycin C in patients with inoperable oesophago-gastric cancer. Ann Oncol 2002;13:1568-1575.
11. Hartmann JT, Quietzsch D, Daikeler T, Kollmannsberger C, Mayer F, Kanz L, Bokemeyer C: Mitomycin C continuous infusion as salvage chemotherapy in pretreated patients with advanced gastric cancer. Anticancer Drugs 1999;10:729-733.
12. De Lisi, V. Cocconi G, Angelini F, Cavicchi F, Di Costanzo F, Gilli G, Rodino C, Soldani M, Tonato M, Finardi C: The combination of cisplatin, doxorubicin, and mitomycin (PAM) compared with the FAM regimen in treating advanced gastric carcinoma. A phase II randomized trial of the Italian Oncology Group for Clinical Research. Cancer 1996;77:245-250.
13. Wils JA, Klein HO, Wagener DJ, Bleiberg H, Reis H, Korsten F, Conroy T, Fickers M, Leyvraz S, Buyse M: Sequential high-dose methotrexate and fluorouracil combined with doxorubicin - a step ahead in the treatment of advanced gastric cancer: A trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group. J Clin Oncol 1991;9:827-831.
14. Kim NK, Park YS, Heo DS, Suh C, Kim SY, Park KC, Kang YK, Shin DB, Kim HT, Kim HJ: A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil alone in the treatment of advanced gastric cancer. Cancer 1993;71:3813-3818.
15. Cullinan SA, Moertel CG, Fleming TR, Rubin JR, Krook JE, Everson LK, Windschitl HE, Twito DI, Marschke RF, Foley JF: A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. Fluorouracil vs fluorouracil and doxorubicin vs fluorouracil, doxorubicin, and mitomycin. JAMA 1985;253:2061-2067.
16. Ross P, Norman A, Cunningham D, Webb A, Iveson T, Padhani A, Prendiville J, Watson M, Massey A, Popescu R, Oates J: A prospective randomised trial of protracted venous infusion 5-fluorouracil with or without mitomycin C in advanced colorectal cancer. Ann Oncol 1997;8:995-1001.