Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus

European Journal of Clinical Nutrition

Volumn 59, Issue 4, 2005, Pages 592-596

  Rahbar, A R ^a   Shakerhosseini, R ^a   Saadat, N ^a   Taleban, F ^a   Pordal, A ^a   Gollestan, B ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apolipoprotein; Diabetes; L carnitine

Indexed keywords

APOLIPOPROTEIN A1; CARNITINE; GLIBENCLAMIDE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FASTING BLOOD GLUCOSE; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

APOLIPOPROTEINS; BLOOD GLUCOSE; CARNITINE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; FASTING; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; IRAN; LIPIDS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC; TIME FACTORS; TRIGLYCERIDES;

EID: 17244363019     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602109     Document Type: Article

References (27)

1. Abdel-aleem S, Karim AM, Zarouk WA, Taylor DA, el-Awady MK & Low JE (1997): Reduced effects of 1-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats. Horm. Metab. Res. 29, 430-435.
2. Broderick TL, Quinney HA & Lopaschuk GD (1992): Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J. Biol. Chem. 267, 3758-4636.
3. Capaldo B, Napoli R, Bonito DP, Albano G & Sacca L (1991): Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients. Diab. Res. Clin. Pract. 14, 191-196.
4. Davis RA & Hui TY (2001): 2000 George Lyman Duff Memorial Lecture: atherosclerosis is a liver disease of the heart. Arterioscler. Thromb. Vasc. Biol. 21, 887-898.
5. De Palo E, Gatti R, Sicolo N, Padovan D, Vettor R & Federspil G (1981): Plasma and urine free L-carnitine in human diabetes mellitus. Acta Diabetol. Lat. 18, 91-95.
6. Derosa G, Cicero FGA, Gaddi A, Mugellini A, Ciccarelli L & Fogari R (2003): The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin. Ther. 25, 1429-1439.
7. Di Donto S, Garavaglia B, Rimoldi M & Carrara F (1992): Clinical and biomedical phenotypes of carnitine deficiencies. In - Carnitine and its Role in Medicine: From Function to Therapy eds. R Ferrari, S Di Mauro, G Sherwood. London: Academic Press.
8. Fritz IB & Marquis NR (1965): The role of acyl-carnitine esters and carnitine palmitoyltransferase in the transport of fatty acyl groups across mitochondrial memberanes. Proc. Natl. Acad. Sci. USA 54, 1226-1230.
9. Gaetano DA, Mingrone G, Castagneto M & Calvani M (1999): Carnitine increases glucose disposal in humans. J. Am. Coll. Nutr. 18, 289-295.
10. Huang B, Wu P, Popov KM & Harris R (2003): Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes 52, 1371-1376.
11. Maccari F, Pessotto P, Ramacci T M & Angelucci L (1985): The effect of exogenous L-carnitine on fat diet induced hyperlipidemia in the rat. Life Sci. 36, 1967-1975.
12. Maebashi M, Kawamura N, Sato M, Imamura A & Yoshinaga K (1978): Lipid-lowering effect of carnitine in patients with type-IV hyperlipoproteinaemia. Lancet 14, 805-807.
13. Mingrone G, Greco VA, Capristo E, Benedetti G, Giancaterini A, Gaetano A & Gasbarrini G (1999): L-carnitine improves glucose disposal in type 2 diabetic patients. J. Am. Coll. Nutr. 18, 77-82.
14. Nakai N, Miyazaki Y, Sato Y, Oshida Y, Nagasaki M, Tanaka M, Nakashima K & Shimomura Y (2002): Exercise training increases the activity of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats. Endocr. J. 49, 547-554.
15. Packard CJ & Sheperd J (1995): Metabolic basis of the atherogenic lipoprotein phenotype. In pp 289-294 Multiple Risk Factor in Cardiovascular Disease eds AM Gotto, C Lenfant, AL Catapano, R Paoletti. Dordrecht, Kluwer Academic Publishers.
16. Reymond LT, Reynolds AS, Swanson AJ, Patnode AC & Bell PF (1987): The effect of oral L-carnitine on lipoprotein composition in the Watanabe heritable hyperlipidemic rabbit (Oryctolagus cuniculus). Commun. Biochem. Physiol. 88, 503-506.
17. Rhew TH & Sachan DS (1986): Dose-dependent lipotropic effect of carnitine in chronic alcoholic rats. J. Nutr. 116, 2263-2269.
18. Rodrigues B, Secombe D & Mcneill JH (1990): Lack of effect oral L-carnitine trearment on lipid metabolism and cardiac function in chronically diabetic rats. Can. J. Phisiol. Pharmacol. 68, 1601-1608.
19. Rodrigues B, Xiang H & Mcneill HJ (1988): Effect of L-carnitine traerment on lipid metabolism and performance in chronically diabetic rats. Diabetes 37, 1358-1364.
20. Secombe WD, James L, Hahn P & Jones E (1987): L-Carnitine trearment in the hyperlipidemic rabbit. Metabolism 36, 1192-1196.
21. Sirtori CR, Calabresi L, Ferrara S, Pazzucconi F, Bondioli A, Baldassarre D, Birreci A & Koverech A (2000): L-Carnitine reduces plasma lipoprotein(a) levels in patients with hyper Lp(a). Nutr. Metab. Cardiovasc. Dis. 10, 247-251.
22. Stefanutti C, Vivenzio A, Lucani G, Di Giacomo S & Lucani E (1998): Effect of L-carnitine on plasma lipoprotein fatty acids pattern in patients with primary hyperlipoproteinemia. Clin. Ther. 149 115-119.
23. Sugden MC & Holness MJ (2002): Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr. Drug Immune Endocr. Metabol. Disord. 2, 151-165.
24. Tamamogullari N, Silig Y, Icagasioglu S & Atalay A (1999): Carnitine deficiency in diabetes mellitus complications. J. Diab. Complic. 13, 251-253.
25. Uziel G, Garavaglia B & Di Donato S (1988): Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. Muscle Nerve 11, 720-724.
26. Vacha MG, Giorcelli G, Siliprandi N & Corsi M (1983): Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patiants: decisive role of low levels of high-density lipoprotein-cholestrol. Am. J. Clin. Nutr. 38, 532-540.
27. Yeh GY, Eisenberg DM, Kaptchuk TJ & Phillips RS (2003): Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26, 1277-1294.